Detail Information

Basic Information:


  VIRBase ID:  

VHID00445911

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-9-3p:           MAK16:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-9-3p MAK16
miRBase
Accession/Entrez ID		 MIMAT0002185 84549
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - MAK16L//RBM13

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MAK16
chr8:33345720(+) A-I      intronic
chr8:33345666(+) A-I      intronic
chr8:33355281(+) A-I      intronic
chr8:33355458(+) A-I      intronic
chr8:33355456(+) A-I      intronic
chr8:33355467(+) A-I      intronic
chr8:33355394(+) A-I      intronic
chr8:33355375(+) A-I      intronic
chr8:33355461(+) A-I      intronic
chr8:33355286(+) A-I      intronic
chr8:33355250(+) A-I      intronic
chr8:33355231(+) A-I      intronic
chr8:33355251(+) A-I      intronic
chr8:33355358(+) A-I      intronic
chr8:33355437(+) A-I      intronic
chr8:33355150(+) A-I      intronic
chr8:33355110(+) A-I      intronic
chr8:33355209(+) A-I      intronic
chr8:33355413(+) A-I      intronic
chr8:33355030(+) A-I      intronic
chr8:33355264(+) A-I      intronic
chr8:33355192(+) A-I      intronic
chr8:33355432(+) A-I      intronic
chr8:33355186(+) A-I      intronic
chr8:33355427(+) A-I      intronic
chr8:33355069(+) A-I      intronic
chr8:33355364(+) A-I      intronic
chr8:33355438(+) A-I      intronic
chr8:33355359(+) A-I      intronic
chr8:33355435(+) A-I      intronic
chr8:33355418(+) A-I      intronic
chr8:33355404(+) A-I      intronic
chr8:33355428(+) A-I      intronic
chr8:33355195(+) A-I      intronic
chr8:33355212(+) A-I      intronic
chr8:33355140(+) A-I      intronic
chr8:33355176(+) A-I      intronic
chr8:33355137(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MAK16
chr8:33355110(+) A-I intron -    22028664
chr8:33355111(+) A-I intron -    22028664
chr8:33355140(+) A-I intron -    22028664
chr8:33355150(+) A-I intron -    22028664
chr8:33355186(+) A-I intron -    22028664
chr8:33355192(+) A-I intron -    22028664
chr8:33355195(+) A-I intron -    22028664
chr8:33355209(+) A-I intron -    22028664
chr8:33355212(+) A-I intron -    22028664
chr8:33355231(+) A-I intron -    22028664
chr8:33355250(+) A-I intron -    22028664
chr8:33355251(+) A-I intron -    22028664
chr8:33355264(+) A-I intron -    22028664
chr8:33355281(+) A-I intron -    22028664
chr8:33355286(+) A-I intron -    22028664
chr8:33355358(+) A-I intron -    22028664
chr8:33355359(+) A-I intron -    22028664
chr8:33355364(+) A-I intron -    22028664
chr8:33355375(+) A-I intron -    22028664
chr8:33355394(+) A-I intron -    22028664
chr8:33355404(+) A-I intron -    22028664
chr8:33355413(+) A-I intron -    22028664
chr8:33355418(+) A-I intron -    22028664
chr8:33355427(+) A-I intron -    22028664
chr8:33355428(+) A-I intron -    22028664
chr8:33355432(+) A-I intron -    22028664
chr8:33355435(+) A-I intron -    22028664
chr8:33355437(+) A-I intron -    22028664
chr8:33355438(+) A-I intron -    22028664
chr8:33355456(+) A-I intron -    22028664
chr8:33355458(+) A-I intron -    22028664
chr8:33355461(+) A-I intron -    22028664
chr8:33355467(+) A-I intron -    22028664

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MAK16
chr8:33342719-33342720(+) m6A 5'UTR//CDS//exon       24981863
chr8:33342801-33342802(+) m6A exon//intron       24981863
chr8:33345917-33345918(+) m6A CDS//exon       24284625//24981863
chr8:33346044-33346045(+) m6A CDS//exon       24284625//24981863
chr8:33346082-33346083(+) m6A CDS//exon       24284625//24981863
chr8:33346619-33346620(+) Y CDS//exon       26075521
chr8:33353087-33353088(+) m6A 3'UTR//CDS       27773535
chr8:33353118-33353119(+) m6A 3'UTR//CDS       27773535
chr8:33353124-33353125(+) m6A 3'UTR//CDS       27773535
chr8:33354192-33354193(+) m6A 3'UTR//CDS       24981863//27773535//22575960
chr8:33355960-33355961(+) m6A 3'UTR//CDS       24209618//24981863//27773535//22575960//22608085
chr8:33356038-33356039(+) m6A 3'UTR//CDS       24209618//24981863//27773535//22608085
chr8:33356065-33356066(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr8:33356114-33356115(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr8:33356138-33356139(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr8:33356173-33356174(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr8:33356178-33356179(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr8:33356187-33356188(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr8:33356214-33356215(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr8:33356257-33356258(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085
chr8:33356338-33356339(+) m6A 3'UTR       27773535
chr8:33356390-33356391(+) m6A 3'UTR       27773535
chr8:33356487-33356488(+) m6A 3'UTR       27773535
chr8:33356721-33356722(+) m6A 3'UTR       27773535
chr8:33356792-33356793(+) m6A 3'UTR       27773535
chr8:33356800-33356801(+) m6A 3'UTR       27773535
chr8:33356807-33356808(+) m6A 3'UTR       27773535
chr8:33356812-33356813(+) m6A 3'UTR       27773535
chr8:33358582-33358583(+) m6A 3'UTR       27773535
chr8:33358630-33358631(+) m6A 3'UTR       27773535
chr8:33358678-33358679(+) m6A 3'UTR       27773535
chr8:33358685-33358686(+) m6A 3'UTR       27773535
chr8:33358696-33358697(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate MAK16
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-9-3p
Interactor2: MAK16

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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