Detail Information

Basic Information:


  VIRBase ID:  

VHID00445851

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-9-3p:           KLHL15:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-9-3p KLHL15
miRBase
Accession/Entrez ID		 MIMAT0002185 80311
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - HEL-S-305

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KLHL15
chrX:24021000(-) A-I      intronic
chrX:24021009(-) A-I      intronic
chrX:24022411(-) A-I      intronic
chrX:24037037(-) A-I      intronic
chrX:24041116(-) A-I      intronic
chrX:24007564(-) A-I      intronic
chrX:24036915(-) A-I      intronic
chrX:24022373(-) A-I      intronic
chrX:24031415(-) A-I      intronic
chrX:24007565(-) A-I      intronic
chrX:24014608(-) A-I      intronic
chrX:24022416(-) A-I      intronic
chrX:24014632(-) A-I      intronic
chrX:24037120(-) A-I      intronic
chrX:24014636(-) A-I      intronic
chrX:24016575(-) A-I      intronic
chrX:24026612(-) A-I      intronic
chrX:24037034(-) A-I      intronic
chrX:24036049(-) A-I      intronic
chrX:24040910(-) A-I      intronic
chrX:24018442(-) A-I      intronic
chrX:24034451(-) A-I      intronic
chrX:24014685(-) A-I      intronic
chrX:24036222(-) A-I      intronic
chrX:24017315(-) A-I      intronic
chrX:24029639(-) A-I      intronic
chrX:24026564(-) A-I      intronic
chrX:24040264(-) A-I      intronic
chrX:24037576(-) A-I      intronic
chrX:24040639(-) A-I      intronic
chrX:24021020(-) A-I      intronic
chrX:24029637(-) A-I      intronic
chrX:24020953(-) A-I      intronic
chrX:24008173(-) A-I      intronic
chrX:24041016(-) A-I      intronic
chrX:24040295(-) A-I      intronic
chrX:24041044(-) A-I      intronic
chrX:24018441(-) A-I      intronic
chrX:24036868(-) A-I      intronic
chrX:24014583(-) A-I      intronic
chrX:24008185(-) A-I      intronic
chrX:24031653(-) A-I      intronic
chrX:24016350(-) A-I      intronic
chrX:24020995(-) A-I      intronic
chrX:24036889(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KLHL15
chrX:24005510-24005511(-) m6A 3'UTR       27773535
chrX:24005957-24005958(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chrX:24005971-24005972(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chrX:24006006-24006007(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chrX:24006071-24006072(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chrX:24006149-24006150(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chrX:24006230-24006231(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chrX:24006285-24006286(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chrX:24006297-24006298(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chrX:24006471-24006472(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chrX:24006480-24006481(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chrX:24006487-24006488(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chrX:24006495-24006496(-) m6A CDS       24284625//24981863//27773535//27371828//22575960//22608085
chrX:24006588-24006589(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chrX:24006598-24006599(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chrX:24006678-24006679(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chrX:24006690-24006691(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chrX:24006782-24006783(-) m6A CDS       24284625//24981863//27773535//27371828//22575960//22608085
chrX:24006787-24006788(-) m6A CDS       24284625//24981863//27773535//27371828//22575960//22608085
chrX:24006943-24006944(-) m6A CDS       24284625//24981863//22575960//22608085
chrX:24006982-24006983(-) m6A CDS       24284625//24981863//26404942//22575960//22608085
chrX:24007008-24007009(-) m6A CDS       24284625//24981863//26404942//22608085
chrX:24007015-24007016(-) m6A CDS       24284625//24981863//26404942//22608085
chrX:24024171-24024172(-) m6A CDS       22608085
chrX:24024331-24024332(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chrX:24024346-24024347(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chrX:24024373-24024374(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chrX:24024396-24024397(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chrX:24024533-24024534(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//22575960//22608085
chrX:24024601-24024602(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085
chrX:24024622-24024623(-) m6A CDS       24284625//24981863//27773535//22608085
chrX:24042982-24042983(-) m6A 5'UTR       27773536
chrX:24042987-24042988(-) m6A 5'UTR       27773536
chrX:24043009-24043010(-) m6A 5'UTR       27773536
chrX:24045259-24045260(-) m6A 5'UTR       27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate KLHL15
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-9-3p
Interactor2: KLHL15

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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