Basic Information:

  VIRBase ID:  

VHID00445384

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-9-3p:  MIMAT0002185          U2SURP:  NM_001320222     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-9-3p	U2SURP
miRBase Accession/Entrez ID	MIMAT0002185	23350
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	fSAPa//SR140

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	U2SURP	chr3:142763935(+) A-I      intronic chr3:142725324(+) A-I      intronic chr3:142763224(+) A-I      intronic chr3:142728262(+) A-I      intronic chr3:142764052(+) A-I      intronic chr3:142764050(+) A-I      intronic chr3:142740003(+) A-I      intronic chr3:142762685(+) A-I      intronic chr3:142762782(+) A-I      intronic chr3:142762786(+) A-I      intronic chr3:142728264(+) A-I      intronic chr3:142736826(+) A-I      intronic chr3:142739818(+) A-I      intronic chr3:142739824(+) A-I      intronic chr3:142725326(+) A-I      intronic chr3:142767526(+) A-I      intronic chr3:142767564(+) A-I      intronic chr3:142767587(+) A-I      intronic chr3:142767863(+) A-I      intronic chr3:142768971(+) A-I      intronic chr3:142768990(+) A-I      intronic chr3:142771027(+) A-I      intronic chr3:142771129(+) A-I      intronic chr3:142771151(+) A-I      intronic chr3:142725411(+) A-I      intronic chr3:142725427(+) A-I      intronic chr3:142726146(+) A-I      intronic chr3:142726148(+) A-I      intronic chr3:142726311(+) A-I      intronic chr3:142726342(+) A-I      intronic chr3:142726353(+) A-I      intronic chr3:142726364(+) A-I      intronic chr3:142726388(+) A-I      intronic chr3:142727658(+) A-I      intronic chr3:142727774(+) A-I      intronic chr3:142728230(+) A-I      intronic chr3:142728261(+) A-I      intronic chr3:142763319(+) A-I      intronic chr3:142728184(+) A-I      intronic chr3:142736728(+) A-I      intronic chr3:142763248(+) A-I      intronic chr3:142725450(+) A-I      intronic chr3:142764161(+) A-I      intronic chr3:142767915(+) A-I      intronic chr3:142736675(+) A-I      intronic chr3:142736687(+) A-I      intronic chr3:142736882(+) A-I      intronic chr3:142771012(+) A-I      intronic chr3:142736688(+) A-I      intronic chr3:142769177(+) A-I      intronic chr3:142768972(+) A-I      intronic chr3:142762777(+) A-I      intronic chr3:142762802(+) A-I      intronic chr3:142762740(+) A-I      intronic chr3:142736808(+) A-I      intronic chr3:142762630(+) A-I      intronic chr3:142736591(+) A-I      intronic chr3:142764100(+) A-I      intronic chr3:142736740(+) A-I      intronic chr3:142736561(+) A-I      intronic chr3:142736511(+) A-I      intronic chr3:142767485(+) A-I      intronic chr3:142736809(+) A-I      intronic chr3:142764090(+) A-I      intronic chr3:142764046(+) A-I      intronic chr3:142768049(+) A-I      intronic chr3:142768969(+) A-I      intronic chr3:142727771(+) A-I      intronic chr3:142768005(+) A-I      intronic chr3:142726490(+) A-I      intronic chr3:142767483(+) A-I      intronic chr3:142771060(+) A-I      intronic chr3:142769189(+) A-I      intronic chr3:142763200(+) A-I      intronic chr3:142736601(+) A-I      intronic chr3:142737722(+) A-I      intronic chr3:142771206(+) A-I      intronic chr3:142736652(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	U2SURP	chr3:142736675(+) A-I intron -    21960545 chr3:142726490(+) A-G intron -    22484847 chr3:142726546(+) A-G intron -    22484847 chr3:142726547(+) A-G intron -    22484847 chr3:142727677(+) A-G intron -    22484847 chr3:142727688(+) A-G intron -    22484847 chr3:142736675(+) A-G intron -    22484847 chr3:142736882(+) A-G intron -    22484847 chr3:142737597(+) G-A intron -    22484847 chr3:142762777(+) A-G intron -    22484847 chr3:142762780(+) A-G intron -    22484847 chr3:142762802(+) A-G intron -    22484847 chr3:142763187(+) A-G intron -    22484847 chr3:142763200(+) A-G intron -    22484847 chr3:142763243(+) A-G intron -    22484847 chr3:142767671(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	U2SURP	chr3:142683471-142683472(+) m6A 5'UTR       27773535 chr3:142683501-142683502(+) m6A intron       27773535 chr3:142683944-142683945(+) m6A intron       27773535 chr3:142685756-142685757(+) m6A intron       27773535 chr3:142685929-142685930(+) m6A intron       25456834//27773535 chr3:142685953-142685954(+) m6A intron       27773535 chr3:142719978-142719979(+) m6A intron       24284625//24209618//25456834//24981863//27773535//22608085 chr3:142720028-142720029(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr3:142720239-142720240(+) m6A 5'UTR//intron       24981863//22608085 chr3:142720277-142720278(+) m6A 5'UTR//intron       24981863//22608085 chr3:142720477-142720478(+) m6A CDS//exon//intron       25456834//24981863 chr3:142721145-142721146(+) m6A 5'UTR//intron       24981863 chr3:142730789-142730790(+) m6A exon//intron       24981863 chr3:142730816-142730817(+) m6A exon//intron       24981863 chr3:142730835-142730836(+) m6A exon//intron       24981863 chr3:142731077-142731078(+) m6A CDS//exon       24981863 chr3:142731105-142731106(+) m6A CDS//exon       24981863 chr3:142731128-142731129(+) m6A CDS//exon       24981863 chr3:142733165-142733166(+) m6A CDS//exon       24981863 chr3:142733212-142733213(+) m6A CDS//exon       24981863//27773535 chr3:142733229-142733230(+) m6A CDS//exon       24981863//27773535 chr3:142735176-142735177(+) m6A CDS//exon       24981863//27773535 chr3:142735687-142735688(+) m6A CDS//exon       24981863//26404942//27773535 chr3:142735694-142735695(+) m6A CDS//exon       24981863//26404942//27773535 chr3:142735780-142735781(+) m6A CDS//exon       24981863//27773535 chr3:142735805-142735806(+) m6A CDS//exon       24981863//27773535 chr3:142735813-142735814(+) m6A CDS//exon       24981863//27773535 chr3:142738854-142738855(+) m6A CDS//exon       24981863 chr3:142739464-142739465(+) m6A CDS//exon       24981863 chr3:142739471-142739472(+) m6A CDS//exon       24981863 chr3:142739497-142739498(+) m6A CDS//exon       24981863 chr3:142741379-142741380(+) m6A CDS//exon       27773535//22575960 chr3:142741413-142741414(+) m6A CDS//exon       27773535//22575960 chr3:142741788-142741789(+) m6A CDS//exon       24981863//26404942 chr3:142741815-142741816(+) m6A CDS//exon       24981863//26404942 chr3:142741853-142741854(+) m6A CDS//exon       24981863//26404942 chr3:142741886-142741887(+) m6A CDS//exon       24981863//26404942 chr3:142741922-142741923(+) m6A exon//intron       24981863//26404942 chr3:142746067-142746068(+) m6A 3'UTR//CDS//exon       - chr3:142747195-142747196(+) m6A 3'UTR//CDS//exon       - chr3:142747200-142747201(+) m6A 3'UTR//CDS//exon       - chr3:142747416-142747417(+) Y 3'UTR//CDS//exon       25219674 chr3:142747438-142747439(+) m6A 3'UTR//CDS//exon       - chr3:142747458-142747459(+) m6A 3'UTR//CDS//exon       - chr3:142756964-142756965(+) m6A 3'UTR//CDS//exon       27773535 chr3:142762012-142762013(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:142762081-142762082(+) Gm 3'UTR//CDS//exon       - chr3:142762102-142762103(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr3:142769824-142769825(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:142769833-142769834(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:142769863-142769864(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:142769878-142769879(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:142772554-142772555(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:142772593-142772594(+) m6A 3'UTR//CDS//exon       24981863//27773535//27371828//22608085 chr3:142775172-142775173(+) m6A 3'UTR//CDS       24981863//27773535 chr3:142775281-142775282(+) m6A 3'UTR//CDS       26404942 chr3:142776316-142776317(+) m6A 3'UTR       27773535 chr3:142776365-142776366(+) m6A 3'UTR       27773535 chr3:142776382-142776383(+) m6A 3'UTR       27773535 chr3:142776428-142776429(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	U2SURP	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-9-3p
Interactor2: U2SURP

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).