Basic Information:

  VIRBase ID:  

VHID00445337

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-9-3p:  MIMAT0002185          BTBD3:  NM_181443     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-9-3p	BTBD3
miRBase Accession/Entrez ID	MIMAT0002185	22903
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	dJ742J24.1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BTBD3	chr20:11875468(+) A-I      intronic chr20:11875474(+) A-I      intronic chr20:11878619(+) A-I      intronic chr20:11875461(+) A-I      intronic chr20:11878629(+) A-I      intronic chr20:11878645(+) A-I      intronic chr20:11876007(+) A-I      intronic chr20:11875464(+) A-I      intronic chr20:11876005(+) A-I      intronic chr20:11875972(+) A-I      intronic chr20:11876022(+) A-I      intronic chr20:11876008(+) A-I      intronic chr20:11878620(+) A-I      intronic chr20:11878630(+) A-I      intronic chr20:11884341(+) A-I      intronic chr20:11889737(+) A-I      intronic chr20:11884355(+) A-I      intronic chr20:11884274(+) A-I      intronic chr20:11889663(+) A-I      intronic chr20:11889819(+) A-I      intronic chr20:11881541(+) A-I      intronic chr20:11887180(+) A-I      intronic chr20:11884519(+) A-I      intronic chr20:11889828(+) A-I      intronic chr20:11889801(+) A-I      intronic chr20:11889802(+) A-I      intronic chr20:11878686(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BTBD3	chr20:11898563-11898564(+) m6A 5'UTR//intron       24981863//22575960 chr20:11898671-11898672(+) m6A 5'UTR//intron       24981863 chr20:11898879-11898880(+) m6A 5'UTR//intron       24284625//22608085 chr20:11898910-11898911(+) m6A 5'UTR//intron       24284625//22575960//22608085 chr20:11898945-11898946(+) m6A CDS//intron       24284625//24981863//22575960//22608085 chr20:11898993-11898994(+) m6A 5'UTR//CDS       24284625//24981863//22575960//22608085 chr20:11899091-11899092(+) m6A 5'UTR//CDS       24284625//24981863//26404942//22608085 chr20:11899103-11899104(+) m1A 5'UTR//CDS       26863196 chr20:11899215-11899216(+) m6A CDS       24981863 chr20:11900457-11900458(+) m6A 3'UTR//CDS//exon       24284625 chr20:11903396-11903397(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr20:11903460-11903461(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr20:11903546-11903547(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:11903573-11903574(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:11903777-11903778(+) m6A CDS//exon       24284625//24209618//24981863//26404942//22575960//22608085 chr20:11904025-11904026(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:11904057-11904058(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:11904135-11904136(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:11904175-11904176(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:11904190-11904191(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:11904295-11904296(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:11904316-11904317(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr20:11904564-11904565(+) m6A 3'UTR       24284625//22608085 chr20:11904673-11904674(+) m6A 3'UTR       24981863//22608085 chr20:11904707-11904708(+) m6A 3'UTR       24981863//22608085 chr20:11904712-11904713(+) m6A 3'UTR       24981863 chr20:11904731-11904732(+) m6A 3'UTR       24981863 chr20:11904739-11904740(+) m6A 3'UTR       24981863 chr20:11905313-11905314(+) Y 3'UTR       25192136

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	BTBD3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-9-3p
Interactor2: BTBD3

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.