Basic Information:

  VIRBase ID:  

VHID00445014

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-9-3p:  MIMAT0002185          SSR3:  NM_001308197     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-9-3p	SSR3
miRBase Accession/Entrez ID	MIMAT0002185	6747
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	TRAPG

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SSR3	chr3:156259404(-) A-I      3'UTR chr3:156259371(-) A-I      3'UTR chr3:156259257(-) A-I      3'UTR chr3:156259275(-) A-I      3'UTR chr3:156259286(-) A-I      3'UTR chr3:156259300(-) A-I      3'UTR chr3:156259318(-) A-I      3'UTR chr3:156259417(-) A-I      3'UTR chr3:156259450(-) A-I      3'UTR chr3:156259292(-) A-I      3'UTR chr3:156258150(-) A-I      3'UTR chr3:156259314(-) A-I      3'UTR chr3:156258236(-) A-I      3'UTR chr3:156259381(-) A-I      3'UTR chr3:156259398(-) A-I      3'UTR chr3:156259385(-) A-I      3'UTR chr3:156258213(-) A-I      3'UTR chr3:156258152(-) A-I      3'UTR chr3:156259378(-) A-I      3'UTR chr3:156259380(-) A-I      3'UTR chr3:156259379(-) A-I      3'UTR chr3:156259373(-) A-I      3'UTR chr3:156259372(-) A-I      3'UTR chr3:156259356(-) A-I      3'UTR chr3:156259335(-) A-I      3'UTR chr3:156259311(-) A-I      3'UTR chr3:156259309(-) A-I      3'UTR chr3:156259308(-) A-I      3'UTR chr3:156258151(-) A-I      3'UTR chr3:156258391(-) A-I      3'UTR chr3:156258348(-) A-I      3'UTR chr3:156258332(-) A-I      3'UTR chr3:156258286(-) A-I      3'UTR chr3:156258246(-) A-I      3'UTR chr3:156258276(-) A-I      3'UTR chr3:156258271(-) A-I      3'UTR chr3:156258257(-) A-I      3'UTR chr3:156258255(-) A-I      3'UTR chr3:156258247(-) A-I      3'UTR chr3:156259367(-) A-I      3'UTR chr3:156258319(-) A-I      3'UTR chr3:156258227(-) A-I      3'UTR chr3:156258308(-) A-I      3'UTR chr3:156259370(-) A-I      3'UTR chr3:156259317(-) A-I      3'UTR chr3:156259397(-) A-I      3'UTR chr3:156259406(-) A-I      3'UTR chr3:156259295(-) A-I      3'UTR chr3:156259324(-) A-I      3'UTR chr3:156258393(-) A-I      3'UTR chr3:156259299(-) A-I      3'UTR chr3:156258283(-) A-I      3'UTR chr3:156259229(-) A-I      3'UTR chr3:156258389(-) A-I      3'UTR chr3:156259288(-) A-I      3'UTR chr3:156259363(-) A-I      3'UTR chr3:156259341(-) A-I      3'UTR chr3:156259340(-) A-I      3'UTR chr3:156259396(-) A-I      3'UTR chr3:156258230(-) A-I      3'UTR chr3:156259331(-) A-I      3'UTR chr3:156258205(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SSR3	chr3:156259229(-) A-I exon 3'UTR    21960545   //22327324 chr3:156258319(-) A-I exon 3'UTR    22327324 chr3:156258389(-) A-I exon 3'UTR    22327324 chr3:156259406(-) A-I exon 3'UTR    21960545 chr3:156259407(-) A-I exon 3'UTR    21960545 chr3:156259295(-) A-I exon 3'UTR    21960545 chr3:156259340(-) A-I exon 3'UTR    21960545 chr3:156259341(-) A-I exon 3'UTR    21960545 chr3:156259363(-) A-I exon 3'UTR    21960545 chr3:156259367(-) A-I exon 3'UTR    21960545 chr3:156258205(-) A-G exon 3'UTR    22484847 chr3:156258273(-) A-G exon 3'UTR    22484847 chr3:156258283(-) A-G exon 3'UTR    22484847 chr3:156258295(-) A-G exon 3'UTR    22484847 chr3:156258308(-) A-G exon 3'UTR    22484847 chr3:156258319(-) A-G exon 3'UTR    22484847 chr3:156258338(-) A-G exon 3'UTR    22484847 chr3:156258393(-) A-T exon 3'UTR    22484847 chr3:156258394(-) G-T exon 3'UTR    22484847 chr3:156259223(-) A-G exon 3'UTR    22484847 chr3:156259229(-) A-G exon 3'UTR    22484847 chr3:156259288(-) A-G exon 3'UTR    22484847 chr3:156259295(-) A-G exon 3'UTR    22484847 chr3:156259299(-) A-G exon 3'UTR    22484847 chr3:156259317(-) A-G exon 3'UTR    22484847 chr3:156259324(-) A-G exon 3'UTR    22484847 chr3:156259340(-) A-G exon 3'UTR    22484847 chr3:156259341(-) A-G exon 3'UTR    22484847 chr3:156259363(-) A-G exon 3'UTR    22484847 chr3:156259367(-) A-G exon 3'UTR    22484847 chr3:156259376(-) A-G exon 3'UTR    22484847 chr3:156259391(-) G-A exon 3'UTR    22484847 chr3:156259396(-) A-G exon 3'UTR    22484847 chr3:156259406(-) A-G exon 3'UTR    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SSR3	chr3:156257947-156257948(-) m6A 3'UTR       27773535 chr3:156258030-156258031(-) m6A 3'UTR       27773535 chr3:156258051-156258052(-) m6A 3'UTR       27773535 chr3:156258275-156258276(-) m6A 3'UTR       27773535 chr3:156258390-156258391(-) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SSR3	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-9-3p
Interactor2: SSR3

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells//EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).