Detail Information

Basic Information:


  VIRBase ID:  

VHID00444664

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8589

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-9-3p:           CDKN1A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-9-3p CDKN1A
miRBase
Accession/Entrez ID		 MIMAT0002185 1026
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - CAP20//CDKN1//CIP1//MDA-6//P21//p21CIP1//SDI1//WAF1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CDKN1A
chr6:36651039(+) A-I      intronic
chr6:36651029(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CDKN1A
chr6:36649966(+) A-G intron -    22484847
chr6:36652654(+) A-G intron -    22484847
chr6:36652771(+) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CDKN1A
chr6:36646593-36646594(+) m6A 5'UTR//exon//intron       24284625//24981863
chr6:36646603-36646604(+) m6A 5'UTR//exon//intron       24284625//24981863
chr6:36651886-36651887(+) m6A CDS//exon       24284625
chr6:36651909-36651910(+) m6A CDS//exon       24284625
chr6:36651954-36651955(+) m6A CDS//exon       24284625//26404942//22575960
chr6:36652026-36652027(+) m6A CDS//exon       24284625//26404942//22575960
chr6:36652046-36652047(+) m6A CDS//exon       24284625//26404942
chr6:36652190-36652191(+) m6A CDS//exon       24284625//25456834//24981863//26404942
chr6:36652203-36652204(+) m6A CDS//exon       24284625//25456834//24981863//26404942
chr6:36652212-36652213(+) m6A CDS//exon       24284625//25456834//24981863//26404942
chr6:36652276-36652277(+) m6A CDS//exon       24284625//25456834//26404942
chr6:36652284-36652285(+) m6A CDS//exon       24284625//25456834//26404942
chr6:36652310-36652311(+) m6A CDS       25456834//26404942
chr6:36654000-36654001(+) m6A 3'UTR       26404942
chr6:36654008-36654009(+) m6A 3'UTR       26404942
chr6:36654037-36654038(+) m6A 3'UTR       26404942
chr6:36654085-36654086(+) m6A 3'UTR       26404942
chr6:36654476-36654477(+) m6A 3'UTR       -
chr6:36654492-36654493(+) m6A 3'UTR       -
chr6:36654498-36654499(+) Am 3'UTR       -
chr6:36654662-36654663(+) m6A 3'UTR       26404942
chr6:36654744-36654745(+) m6A 3'UTR       26404942
chr6:36654756-36654757(+) m6A 3'UTR       26404942
chr6:36654788-36654789(+) m6A 3'UTR       26404942
chr6:36654909-36654910(+) m6A 3'UTR       24284625
chr6:36654942-36654943(+) m6A 3'UTR       24284625
chr6:36654993-36654994(+) m6A 3'UTR       24284625
chr6:36655000-36655001(+) m6A 3'UTR       24284625
chr6:36655017-36655018(+) m6A 3'UTR       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate CDKN1A
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-9-3p
Interactor2: CDKN1A

Evidence Support:


Strong-Evidence Indicator assay
Weak-Evidence PAR-CLIP
Support Database VmiReg

References:


PMID 22100165 Target region 3'UTR
Source VmiReg Interactor1 expression None
Tissue or cell line 293T cells Interactor2 expression Downregulation
Description Of the 36 miRNA-3'UTR pairs, 28 showed significant downregulation of 3'UTR indicator activity.

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