Basic Information:

  VIRBase ID:  

VHID00444210

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-9-5p:  MIMAT0002184          PIGW:  NM_001346755     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-9-5p	PIGW
miRBase Accession/Entrez ID	MIMAT0002184	284098
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	Gwt1//HPMRS5

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PIGW	chr17:34891606(+) A-I      intronic chr17:34894622(+) A-I      3'UTR chr17:34894775(+) A-I      3'UTR chr17:34891605(+) A-I      intronic chr17:34894878(+) A-I      3'UTR chr17:34894866(+) A-I      3'UTR

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PIGW	chr17:34890990-34890991(+) m6A 5'UTR//intron       24209618//25456834//24981863//27371828 chr17:34891087-34891088(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//22608085 chr17:34891219-34891220(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr17:34891246-34891247(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr17:34891408-34891409(+) m6A 5'UTR//intron       24284625//24209618//22608085 chr17:34892998-34892999(+) m6A CDS       24284625//24209618//24981863//22608085 chr17:34893112-34893113(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:34893253-34893254(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:34893267-34893268(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:34893302-34893303(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr17:34893392-34893393(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr17:34893424-34893425(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr17:34893439-34893440(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr17:34893551-34893552(+) m6A CDS       24284625//24209618//24981863//22608085 chr17:34893630-34893631(+) m6A CDS       24209618//24981863//22608085 chr17:34893659-34893660(+) m6A CDS       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PIGW	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleolus K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-9-5p
Interactor2: PIGW

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).