Basic Information:

  VIRBase ID:  

VHID00443927

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-9-5p:  MIMAT0002184          RUNDC3B:  NM_138290     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-9-5p	RUNDC3B
miRBase Accession/Entrez ID	MIMAT0002184	154661
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	RPIB9//RPIP9

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RUNDC3B	chr7:87305261(+) A-I      intronic chr7:87305296(+) A-I      intronic chr7:87305422(+) A-I      intronic chr7:87305402(+) A-I      intronic chr7:87305400(+) A-I      intronic chr7:87305396(+) A-I      intronic chr7:87305384(+) A-I      intronic chr7:87305256(+) A-I      intronic chr7:87313836(+) A-I      intronic chr7:87331205(+) A-I      intronic chr7:87331210(+) A-I      intronic chr7:87305255(+) A-I      intronic chr7:87430866(+) A-I      intronic chr7:87441669(+) A-I      intronic chr7:87350178(+) A-I      intronic chr7:87440766(+) A-I      intronic chr7:87350056(+) A-I      intronic chr7:87440836(+) A-I      intronic chr7:87403127(+) A-I      intronic chr7:87440806(+) A-I      intronic chr7:87431516(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RUNDC3B	Chromatin K562 cells     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-9-5p
Interactor2: RUNDC3B

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).