Basic Information:

  VIRBase ID:  

VHID00441140

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-9-5p:  MIMAT0002184          TNFSF9:  NM_003811     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-9-5p	TNFSF9
miRBase Accession/Entrez ID	MIMAT0002184	8744
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	4-1BB-L//CD137L//TNLG5A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TNFSF9	chr19:6535717(+) A-I      3'UTR chr19:6535806(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TNFSF9	chr19:6535728(+) G-T intron -    22484847 chr19:6535872(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TNFSF9	chr19:6531075-6531076(+) m6A CDS       24981863 chr19:6531303-6531304(+) m6A CDS       22575960 chr19:6534697-6534698(+) m6A CDS       24284625//22575960 chr19:6534862-6534863(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:6534892-6534893(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:6535019-6535020(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:6535052-6535053(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr19:6535104-6535105(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr19:6535138-6535139(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr19:6535218-6535219(+) m6A 3'UTR       24284625//24981863//22575960//22608085 chr19:6535249-6535250(+) m6A 3'UTR       24284625//24981863//22608085 chr19:6535349-6535350(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr19:6535412-6535413(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr19:6535420-6535421(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr19:6535561-6535562(+) m6A 3'UTR       24284625//24209618//24981863 chr19:6535575-6535576(+) m6A 3'UTR       24981863 chr19:6535620-6535621(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TNFSF9	Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-9-5p
Interactor2: TNFSF9

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).