Basic Information:

  VIRBase ID:  

VHID00441028

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-9-5p:  MIMAT0002184          MALL:  NM_001371559     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-9-5p	MALL
miRBase Accession/Entrez ID	MIMAT0002184	7851
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BENE

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MALL	chr2:110841666-110841667(-) m6A 3'UTR       24981863 chr2:110841671-110841672(-) m6A 3'UTR       24981863 chr2:110841677-110841678(-) m6A 3'UTR       24981863 chr2:110841746-110841747(-) m6A 3'UTR       24981863 chr2:110841922-110841923(-) m6A 3'UTR       24981863 chr2:110842034-110842035(-) m6A 3'UTR       24981863 chr2:110842049-110842050(-) m6A 3'UTR       24981863 chr2:110842127-110842128(-) m6A 3'UTR       24981863 chr2:110842167-110842168(-) m6A 3'UTR       24981863 chr2:110842183-110842184(-) m6A 3'UTR       24981863 chr2:110842221-110842222(-) m6A 3'UTR       24981863 chr2:110842295-110842296(-) m6A 3'UTR       24981863 chr2:110843000-110843001(-) m6A 3'UTR       24981863 chr2:110843014-110843015(-) m6A 3'UTR       24981863 chr2:110843045-110843046(-) m6A 3'UTR       24981863 chr2:110843098-110843099(-) m6A 3'UTR       24981863 chr2:110843127-110843128(-) m6A 3'UTR       24981863 chr2:110873501-110873502(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MALL	Exosome Blood     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-9-5p
Interactor2: MALL

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	RNAHybrid//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).