Basic Information:

  VIRBase ID:  

VHID00439900

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-9-5p:  MIMAT0002184          SCARB2:  NM_001204255     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-9-5p	SCARB2
miRBase Accession/Entrez ID	MIMAT0002184	950
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	AMRF//CD36L2//EPM4//HLGP85//LGP85//LIMP-2//LIMPII//SR-BII

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SCARB2	chr4:77111405(-) A-I      intronic chr4:77113040(-) A-I      intronic chr4:77113062(-) A-I      intronic chr4:77113068(-) A-I      intronic chr4:77113080(-) A-I      intronic chr4:77113103(-) A-I      intronic chr4:77111362(-) A-I      intronic chr4:77113905(-) A-I      intronic chr4:77113961(-) A-I      intronic chr4:77113972(-) A-I      intronic chr4:77104068(-) A-I      intronic chr4:77104052(-) A-I      intronic chr4:77104044(-) A-I      intronic chr4:77111381(-) A-I      intronic chr4:77104043(-) A-I      intronic chr4:77111359(-) A-I      intronic chr4:77111358(-) A-I      intronic chr4:77105878(-) A-I      intronic chr4:77105867(-) A-I      intronic chr4:77105866(-) A-I      intronic chr4:77113948(-) A-I      intronic chr4:77113923(-) A-I      intronic chr4:77113175(-) A-I      intronic chr4:77111861(-) A-I      intronic chr4:77105901(-) A-I      intronic chr4:77105872(-) A-I      intronic chr4:77104038(-) A-I      intronic chr4:77110867(-) A-I      intronic chr4:77115394(-) A-I      intronic chr4:77080712(-) A-I      3'UTR chr4:77080695(-) A-I      3'UTR chr4:77080692(-) A-I      3'UTR chr4:77080683(-) A-I      3'UTR chr4:77080642(-) A-I      3'UTR chr4:77100433(-) A-I      intronic chr4:77110871(-) A-I      intronic chr4:77113197(-) A-I      intronic chr4:77111290(-) A-I      intronic chr4:77110752(-) A-I      intronic chr4:77105852(-) A-I      intronic chr4:77080860(-) A-I      3'UTR chr4:77110732(-) A-I      intronic chr4:77110683(-) A-I      intronic chr4:77113191(-) A-I      intronic chr4:77111344(-) A-I      intronic chr4:77113196(-) A-I      intronic chr4:77102991(-) A-I      intronic chr4:77111438(-) A-I      intronic chr4:77105853(-) A-I      intronic chr4:77111395(-) A-I      intronic chr4:77111435(-) A-I      intronic chr4:77116511(-) A-I      intronic chr4:77102975(-) A-I      intronic chr4:77105928(-) A-I      intronic chr4:77113093(-) A-I      intronic chr4:77105927(-) A-I      intronic chr4:77110880(-) A-I      intronic chr4:77124260(-) A-I      intronic chr4:77102790(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SCARB2	chr4:77080771(-) A-T exon 3'UTR    21725310 chr4:77115309(-) A-G intron -    22484847 chr4:77102991(-) A-G intron -    22484847 chr4:77103005(-) A-G intron -    22484847 chr4:77110823(-) A-G intron -    22484847 chr4:77111837(-) A-G intron -    22484847 chr4:77113889(-) A-G intron -    22484847 chr4:77113974(-) A-G intron -    22484847 chr4:77116511(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SCARB2	chr4:77082728-77082729(-) m6A 3'UTR       24981863 chr4:77082752-77082753(-) m6A 3'UTR       24981863 chr4:77082800-77082801(-) m6A 3'UTR       24981863//27371828 chr4:77082840-77082841(-) m6A 3'UTR       27371828 chr4:77134591-77134592(-) Gm CDS       - chr4:77134828-77134829(-) m6A 5'UTR       27773536 chr4:77134921-77134922(-) m6A 5'UTR       24981863//27773536 chr4:77134927-77134928(-) m6A 5'UTR       24981863//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SCARB2	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-9-5p
Interactor2: SCARB2

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).