Detail Information

Basic Information:


  VIRBase ID:  

VHID00439613

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-2-5p:           ZC3H6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-2-5p ZC3H6
miRBase
Accession/Entrez ID		 MIMAT0002183 376940
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - ZC3HDC6

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZC3H6
chr2:113077730(+) A-I      intronic
chr2:113077566(+) A-I      intronic
chr2:113077540(+) A-I      intronic
chr2:113077695(+) A-I      intronic
chr2:113043337(+) A-I      intronic
chr2:113096626(+) A-I      3'UTR
chr2:113096598(+) A-I      3'UTR
chr2:113043083(+) A-I      intronic
chr2:113096586(+) A-I      3'UTR
chr2:113043075(+) A-I      intronic
chr2:113043063(+) A-I      intronic
chr2:113043035(+) A-I      intronic
chr2:113043361(+) A-I      intronic
chr2:113043342(+) A-I      intronic
chr2:113066535(+) A-I      intronic
chr2:113066518(+) A-I      intronic
chr2:113066447(+) A-I      intronic
chr2:113045364(+) A-I      intronic
chr2:113043418(+) A-I      intronic
chr2:113043373(+) A-I      intronic
chr2:113043367(+) A-I      intronic
chr2:113043352(+) A-I      intronic
chr2:113043351(+) A-I      intronic
chr2:113043132(+) A-I      intronic
chr2:113043038(+) A-I      intronic
chr2:113042973(+) A-I      intronic
chr2:113036125(+) A-I      intronic
chr2:113045386(+) A-I      intronic
chr2:113084294(+) A-I      intronic
chr2:113084293(+) A-I      intronic
chr2:113077205(+) A-I      intronic
chr2:113077112(+) A-I      intronic
chr2:113077013(+) A-I      intronic
chr2:113070362(+) A-I      intronic
chr2:113086293(+) A-I      intronic
chr2:113085560(+) A-I      intronic
chr2:113085531(+) A-I      intronic
chr2:113066514(+) A-I      intronic
chr2:113055536(+) A-I      intronic
chr2:113056600(+) A-I      intronic
chr2:113043051(+) A-I      intronic
chr2:113066531(+) A-I      intronic
chr2:113055545(+) A-I      intronic
chr2:113045253(+) A-I      intronic
chr2:113070184(+) A-I      intronic
chr2:113066192(+) A-I      intronic
chr2:113066054(+) A-I      intronic
chr2:113070237(+) A-I      intronic
chr2:113043163(+) A-I      intronic
chr2:113076801(+) A-I      intronic
chr2:113073266(+) A-I      intronic
chr2:113096654(+) A-I      3'UTR
chr2:113095314(+) A-I      3'UTR
chr2:113095779(+) A-I      3'UTR
chr2:113036096(+) A-I      intronic
chr2:113076867(+) A-I      intronic
chr2:113077058(+) A-I      intronic
chr2:113043463(+) A-I      intronic
chr2:113076990(+) A-I      intronic
chr2:113055572(+) A-I      intronic
chr2:113087837(+) A-I      intronic
chr2:113043209(+) A-I      intronic
chr2:113068851(+) A-I      intronic
chr2:113076989(+) A-I      intronic
chr2:113043014(+) A-I      intronic
chr2:113066209(+) A-I      intronic
chr2:113076810(+) A-I      intronic
chr2:113066127(+) A-I      intronic
chr2:113070168(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZC3H6
chr2:113045253(+) A-G intron -    22484847
chr2:113047339(+) T-G intron -    22484847
chr2:113047340(+) G-T intron -    22484847
chr2:113047341(+) A-T intron -    22484847
chr2:113076810(+) A-G intron -    22484847
chr2:113082887(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZC3H6
chr2:113033311-113033312(+) m6A 5'UTR       22608085
chr2:113033535-113033536(+) m6A 5'UTR       27773536//22608085
chr2:113033569-113033570(+) m6A 5'UTR       24981863//27773535//27773536//22608085
chr2:113033578-113033579(+) m6A CDS       24981863//27773535//27773536//22608085
chr2:113033585-113033586(+) m6A CDS       24981863//27773535//27773536//22608085
chr2:113057548-113057549(+) m6A CDS//exon       24981863//27773535//22608085
chr2:113057599-113057600(+) m6A CDS//exon       24981863//27773535//22608085
chr2:113060836-113060837(+) m6A CDS//exon       24981863//27773535//22608085
chr2:113060861-113060862(+) m6A CDS//exon       24981863
chr2:113082700-113082701(+) m6A CDS       24981863//22608085
chr2:113082730-113082731(+) m6A CDS       24981863//22608085
chr2:113088649-113088650(+) m6A CDS       24284625//24981863//27773535//22608085
chr2:113088660-113088661(+) m6A CDS       24284625//24981863//27773535//22608085
chr2:113088670-113088671(+) m6A CDS       24284625//24981863//27773535//22608085
chr2:113088702-113088703(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr2:113088726-113088727(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr2:113088752-113088753(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr2:113088778-113088779(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr2:113088794-113088795(+) m6A CDS       24284625//25456834//24981863//22575960//22608085
chr2:113088834-113088835(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr2:113088945-113088946(+) m6A CDS       24284625//24209618//24981863//22608085
chr2:113088987-113088988(+) m6A CDS       24284625//24209618//24981863//22608085
chr2:113089065-113089066(+) m6A CDS       24284625//24981863//22608085
chr2:113089088-113089089(+) m6A CDS       24284625//24981863//22608085
chr2:113089104-113089105(+) m6A CDS       24284625//24981863//22608085
chr2:113089119-113089120(+) m6A CDS       24284625//24981863//22608085
chr2:113089142-113089143(+) m6A CDS       24284625//24981863//22608085
chr2:113089167-113089168(+) m6A CDS       24284625//24981863//22608085
chr2:113089319-113089320(+) m6A CDS       24284625//24981863//22608085
chr2:113089338-113089339(+) m6A CDS       24284625//24981863//22608085
chr2:113089349-113089350(+) m6A CDS       24284625//24981863//22608085
chr2:113089386-113089387(+) m6A CDS       24284625//24981863//22608085
chr2:113089419-113089420(+) m6A CDS       24284625//24981863//22608085
chr2:113089499-113089500(+) m6A CDS       24284625//24981863//22608085
chr2:113089531-113089532(+) m6A CDS       24284625//24981863//22608085
chr2:113089575-113089576(+) m6A CDS       24284625//24981863//22608085
chr2:113089606-113089607(+) m6A CDS       24284625//24981863//22608085
chr2:113089703-113089704(+) m6A CDS       24284625//25456834//24981863//22608085
chr2:113089712-113089713(+) m6A CDS       24284625//25456834//24981863//22608085
chr2:113089750-113089751(+) m6A CDS//exon       24284625//25456834//24981863//22608085
chr2:113089755-113089756(+) m6A CDS//exon       24284625//25456834//24981863//22608085
chr2:113089788-113089789(+) m6A CDS//exon       24284625//25456834//24981863//22608085
chr2:113089959-113089960(+) m6A CDS//intron       -
chr2:113096692-113096693(+) m6A 3'UTR       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ZC3H6
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-2-5p
Interactor2: ZC3H6

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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