Basic Information:

  VIRBase ID:  

VHID00439369

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-2-5p:  MIMAT0002183          RUNDC3B:  NM_138290     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-2-5p	RUNDC3B
miRBase Accession/Entrez ID	MIMAT0002183	154661
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	RPIB9//RPIP9

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RUNDC3B	chr7:87305261(+) A-I      intronic chr7:87305296(+) A-I      intronic chr7:87305422(+) A-I      intronic chr7:87305402(+) A-I      intronic chr7:87305400(+) A-I      intronic chr7:87305396(+) A-I      intronic chr7:87305384(+) A-I      intronic chr7:87305256(+) A-I      intronic chr7:87313836(+) A-I      intronic chr7:87331205(+) A-I      intronic chr7:87331210(+) A-I      intronic chr7:87305255(+) A-I      intronic chr7:87430866(+) A-I      intronic chr7:87441669(+) A-I      intronic chr7:87350178(+) A-I      intronic chr7:87440766(+) A-I      intronic chr7:87350056(+) A-I      intronic chr7:87440836(+) A-I      intronic chr7:87403127(+) A-I      intronic chr7:87440806(+) A-I      intronic chr7:87431516(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RUNDC3B	Chromatin K562 cells     - Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-2-5p
Interactor2: RUNDC3B

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).