Detail Information

Basic Information:


  VIRBase ID:  

VHID00439140

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-2-5p:           ANKRD40:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-2-5p ANKRD40
miRBase
Accession/Entrez ID		 MIMAT0002183 91369
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - -

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ANKRD40
chr17:48771274(-) A-I      3'UTR
chr17:48784125(-) A-I      intronic
chr17:48783098(-) A-I      intronic
chr17:48771266(-) A-I      3'UTR
chr17:48783512(-) A-I      intronic
chr17:48771247(-) A-I      3'UTR
chr17:48771248(-) A-I      3'UTR
chr17:48783130(-) A-I      intronic
chr17:48783189(-) A-I      intronic
chr17:48783190(-) A-I      intronic
chr17:48783192(-) A-I      intronic
chr17:48771249(-) A-I      3'UTR
chr17:48784153(-) A-I      intronic
chr17:48781764(-) A-I      intronic
chr17:48782308(-) A-I      intronic
chr17:48782311(-) A-I      intronic
chr17:48782326(-) A-I      intronic
chr17:48782340(-) A-I      intronic
chr17:48782353(-) A-I      intronic
chr17:48782363(-) A-I      intronic
chr17:48782388(-) A-I      intronic
chr17:48783665(-) A-I      intronic
chr17:48783681(-) A-I      intronic
chr17:48783702(-) A-I      intronic
chr17:48783731(-) A-I      intronic
chr17:48784018(-) A-I      intronic
chr17:48784045(-) A-I      intronic
chr17:48783133(-) A-I      intronic
chr17:48783128(-) A-I      intronic
chr17:48784167(-) A-I      intronic
chr17:48783594(-) A-I      intronic
chr17:48783611(-) A-I      intronic
chr17:48781619(-) A-I      intronic
chr17:48783621(-) A-I      intronic
chr17:48783647(-) A-I      intronic
chr17:48783656(-) A-I      intronic
chr17:48783660(-) A-I      intronic
chr17:48783662(-) A-I      intronic
chr17:48783271(-) A-I      intronic
chr17:48783516(-) A-I      intronic
chr17:48783556(-) A-I      intronic
chr17:48784143(-) A-I      intronic
chr17:48783090(-) A-I      intronic
chr17:48783089(-) A-I      intronic
chr17:48783154(-) A-I      intronic
chr17:48783195(-) A-I      intronic
chr17:48783186(-) A-I      intronic
chr17:48781863(-) A-I      intronic
chr17:48781761(-) A-I      intronic
chr17:48783238(-) A-I      intronic
chr17:48783159(-) A-I      intronic
chr17:48779581(-) A-I      intronic
chr17:48783127(-) A-I      intronic
chr17:48783580(-) A-I      intronic
chr17:48783191(-) A-I      intronic
chr17:48781631(-) A-I      intronic
chr17:48784060(-) A-I      intronic
chr17:48783136(-) A-I      intronic
chr17:48783050(-) A-I      intronic
chr17:48783257(-) A-I      intronic
chr17:48783115(-) A-I      intronic
chr17:48783150(-) A-I      intronic
chr17:48783199(-) A-I      intronic
chr17:48783715(-) A-I      intronic
chr17:48781837(-) A-I      intronic
chr17:48784028(-) A-I      intronic
chr17:48783118(-) A-I      intronic
chr17:48784183(-) A-I      intronic
chr17:48777722(-) A-I      intronic
chr17:48783301(-) A-I      intronic
chr17:48783262(-) A-I      intronic
chr17:48782232(-) A-I      intronic
chr17:48783182(-) A-I      intronic
chr17:48783293(-) A-I      intronic
chr17:48783200(-) A-I      intronic
chr17:48782219(-) A-I      intronic
chr17:48783056(-) A-I      intronic
chr17:48784202(-) A-I      intronic
chr17:48781688(-) A-I      intronic
chr17:48783240(-) A-I      intronic
chr17:48783505(-) A-I      intronic
chr17:48783292(-) A-I      intronic
chr17:48783225(-) A-I      intronic
chr17:48782909(-) A-I      intronic
chr17:48783119(-) A-I      intronic
chr17:48783124(-) A-I      intronic
chr17:48783176(-) A-I      intronic
chr17:48784208(-) A-I      intronic
chr17:48783097(-) A-I      intronic
chr17:48783204(-) A-I      intronic
chr17:48783226(-) A-I      intronic
chr17:48783579(-) A-I      intronic
chr17:48777721(-) A-I      intronic
chr17:48783215(-) A-I      intronic
chr17:48782983(-) A-I      intronic
chr17:48782206(-) A-I      intronic
chr17:48783249(-) A-I      intronic
chr17:48783629(-) A-I      intronic
chr17:48781794(-) A-I      intronic
chr17:48783201(-) A-I      intronic
chr17:48782231(-) A-I      intronic
chr17:48782982(-) A-I      intronic
chr17:48782158(-) A-I      intronic
chr17:48783094(-) A-I      intronic
chr17:48782286(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ANKRD40
chr17:48783089(-) A-I intron -    22028664
chr17:48783090(-) A-I intron -    22028664
chr17:48783097(-) A-I intron -    22028664
chr17:48783115(-) A-I intron -    22028664
chr17:48783136(-) A-I intron -    22028664
chr17:48783154(-) A-I intron -    22028664
chr17:48783159(-) A-I intron -    22028664
chr17:48783176(-) A-I intron -    22028664
chr17:48783182(-) A-I intron -    22028664
chr17:48783186(-) A-I intron -    22028664
chr17:48783191(-) A-I intron -    22028664
chr17:48783195(-) A-I intron -    22028664
chr17:48783199(-) A-I intron -    22028664
chr17:48783201(-) A-I intron -    22028664
chr17:48783204(-) A-I intron -    22028664
chr17:48783215(-) A-I intron -    22028664
chr17:48783225(-) A-I intron -    22028664
chr17:48783226(-) A-I intron -    22028664
chr17:48783238(-) A-I intron -    22028664
chr17:48783249(-) A-I intron -    22028664
chr17:48783257(-) A-I intron -    22028664
chr17:48783262(-) A-I intron -    22028664
chr17:48783292(-) A-I intron -    22028664
chr17:48781863(-) A-G intron -    22484847
chr17:48782231(-) A-G intron -    22484847
chr17:48782232(-) A-G intron -    22484847
chr17:48782286(-) A-G intron -    22484847
chr17:48783118(-) A-G intron -    22484847
chr17:48783176(-) A-G intron -    22484847
chr17:48783199(-) A-G intron -    22484847
chr17:48783200(-) A-G intron -    22484847
chr17:48783579(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ANKRD40
chr17:48770786-48770787(-) Y 3'UTR       26075521
chr17:48771286-48771287(-) m6A 3'UTR       24209618
chr17:48771321-48771322(-) m6A 3'UTR       24209618
chr17:48772560-48772561(-) m6A 3'UTR       27773535
chr17:48772607-48772608(-) m6A 3'UTR       27773535
chr17:48772696-48772697(-) m6A 3'UTR       24284625//27773535//22608085
chr17:48772850-48772851(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:48772888-48772889(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:48772911-48772912(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:48772928-48772929(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr17:48773130-48773131(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:48773151-48773152(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr17:48773297-48773298(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48773346-48773347(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48773369-48773370(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr17:48773462-48773463(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr17:48776925-48776926(-) m6A CDS       24284625//27773535
chr17:48776942-48776943(-) m6A CDS       24284625//27773535
chr17:48777004-48777005(-) m6A CDS       24284625//27773535
chr17:48777017-48777018(-) m6A CDS       24284625//27773535
chr17:48777033-48777034(-) m6A CDS       24284625//27773535
chr17:48777189-48777190(-) m6A CDS       24981863//26404942//27773535
chr17:48777200-48777201(-) m1A CDS       26863196
chr17:48777247-48777248(-) m1A CDS       26863196
chr17:48777907-48777908(-) m6A exon//intron       24981863
chr17:48778021-48778022(-) Y 5'UTR//CDS//exon       26075521
chr17:48778047-48778048(-) m6A 5'UTR//CDS//exon       24209618//24981863//27773535
chr17:48778075-48778076(-) m6A 5'UTR//CDS//exon       24209618//24981863//27773535
chr17:48778174-48778175(-) m6A 5'UTR//intron       24209618
chr17:48784905-48784906(-) m6A CDS//exon       24209618//24981863
chr17:48784931-48784932(-) m6A CDS//exon       24209618//24981863
chr17:48784950-48784951(-) m6A CDS//exon       24209618//24981863
chr17:48785272-48785273(-) m6A 5'UTR       24981863//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ANKRD40
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-2-5p
Interactor2: ANKRD40

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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