Basic Information:

  VIRBase ID:  

VHID00439005

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-2-5p:  MIMAT0002183          MXD3:  NM_031300     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-2-5p	MXD3
miRBase Accession/Entrez ID	MIMAT0002183	83463
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BHLHC13//MAD3//MYX

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MXD3	chr5:176728522-176728523(-) m6A exon       24284625//25456834//24981863//28052920//27773535//27371828//22608085 chr5:176728542-176728543(-) m6A exon       24284625//25456834//24981863//28052920//27773535//27371828//22608085 chr5:176728590-176728591(-) m6A exon       24284625//25456834//24981863//28052920//27773535//27371828//22608085 chr5:176728690-176728691(-) m6A exon       24284625//25456834//27773535//27371828//22608085 chr5:176728774-176728775(-) m6A exon       - chr5:176729143-176729144(-) m6A exon       27773535 chr5:176729155-176729156(-) m6A exon       27773535 chr5:176729328-176729329(-) m6A intron       27773535 chr5:176729399-176729400(-) m6A exon       27773535 chr5:176729408-176729409(-) m6A exon       27773535 chr5:176729426-176729427(-) m6A exon       27773535 chr5:176729447-176729448(-) m6A exon       27773535 chr5:176729595-176729596(-) m6A exon       27773535 chr5:176729635-176729636(-) m6A exon       27773535 chr5:176730029-176730030(-) m6A exon       24209618//27773535 chr5:176730034-176730035(-) m6A exon       24209618//27773535 chr5:176730077-176730078(-) m6A exon       24209618//27773535 chr5:176730228-176730229(-) m6A exon       24284625//27773535//27371828//27773536 chr5:176730319-176730320(-) m6A exon       24284625//27371828//27773536 chr5:176730486-176730487(-) m6A intron       24284625//27371828//27773536 chr5:176730662-176730663(-) m6A intron       24284625//27371828//27773536 chr5:176732511-176732512(-) m6A 3'UTR//intron       27371828//27773536 chr5:176733106-176733107(-) m6A 3'UTR//intron       27773535 chr5:176733148-176733149(-) m6A 3'UTR//intron       27773535 chr5:176733182-176733183(-) m6A 3'UTR//intron       27773535 chr5:176733242-176733243(-) m6A 3'UTR//intron       27773535 chr5:176733283-176733284(-) m6A 3'UTR//intron       - chr5:176733377-176733378(-) m6A 3'UTR//intron       - chr5:176733562-176733563(-) m6A 3'UTR//intron       24284625//24981863//27773535 chr5:176733575-176733576(-) m6A 3'UTR//intron       24284625//24981863//27773535 chr5:176733668-176733669(-) m6A 3'UTR//intron       24284625//24981863//27773535 chr5:176733675-176733676(-) m6A 3'UTR//intron       24284625//27773535 chr5:176734245-176734246(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27371828 chr5:176734274-176734275(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27371828//22608085 chr5:176734307-176734308(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//27371828//22608085 chr5:176734370-176734371(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085 chr5:176734380-176734381(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085 chr5:176734390-176734391(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085 chr5:176734440-176734441(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr5:176734455-176734456(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr5:176734469-176734470(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr5:176734478-176734479(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr5:176734719-176734720(-) m6A CDS//intron       24284625//24209618//25456834//27371828//27773536//22608085 chr5:176734786-176734787(-) m6A CDS//exon       24284625//24209618//25456834//27371828//27773536//22608085 chr5:176734792-176734793(-) m6A CDS//exon       24284625//24209618//25456834//27371828//27773536//22608085 chr5:176734822-176734823(-) m6A CDS//exon       24284625//24209618//25456834//27371828//27773536//22608085 chr5:176734831-176734832(-) m6A CDS//exon       24284625//24209618//25456834//27371828//27773536//22608085 chr5:176737555-176737556(-) m6A exon//intron       24284625//24209618//27371828//27773536 chr5:176737682-176737683(-) m6A 5'UTR//CDS//exon//intron       24284625//27773536 chr5:176737792-176737793(-) m6A exon//intron       - chr5:176737807-176737808(-) m6A exon//intron       - chr5:176738163-176738164(-) m6A exon//intron       27773535 chr5:176738196-176738197(-) m6A exon//intron       27773535 chr5:176738226-176738227(-) m6A exon//intron       27773535 chr5:176738388-176738389(-) m6A 5'UTR//CDS//exon       24284625//27371828//27773536 chr5:176738419-176738420(-) m1A 5'UTR//CDS//exon       26863196//26863410 chr5:176738498-176738499(-) m6A 5'UTR//intron       24284625//27371828//27773536 chr5:176738825-176738826(-) m6A 5'UTR//CDS//exon       24284625//24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MXD3	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-2-5p
Interactor2: MXD3

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.