Basic Information:

  VIRBase ID:  

VHID00438484

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.2381

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-2-5p:  MIMAT0002183          USP53:  NM_001389661     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-2-5p	USP53
miRBase Accession/Entrez ID	MIMAT0002183	54532
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	USP53	chr4:120186161(+) A-I      intronic chr4:120186162(+) A-I      intronic chr4:120186169(+) A-I      intronic chr4:120186178(+) A-I      intronic chr4:120186183(+) A-I      intronic chr4:120187277(+) A-I      intronic chr4:120187317(+) A-I      intronic chr4:120187326(+) A-I      intronic chr4:120187327(+) A-I      intronic chr4:120202967(+) A-I      intronic chr4:120202968(+) A-I      intronic chr4:120202969(+) A-I      intronic chr4:120202970(+) A-I      intronic chr4:120202984(+) A-I      intronic chr4:120203006(+) A-I      intronic chr4:120203012(+) A-I      intronic chr4:120203019(+) A-I      intronic chr4:120203029(+) A-I      intronic chr4:120203032(+) A-I      intronic chr4:120148032(+) A-I      intronic chr4:120148011(+) A-I      intronic chr4:120205053(+) A-I      intronic chr4:120148738(+) A-I      intronic chr4:120146652(+) A-I      intronic chr4:120205989(+) A-I      intronic chr4:120205995(+) A-I      intronic chr4:120206029(+) A-I      intronic chr4:120202978(+) A-I      intronic chr4:120146655(+) A-I      intronic chr4:120148010(+) A-I      intronic chr4:120148038(+) A-I      intronic chr4:120148058(+) A-I      intronic chr4:120148173(+) A-I      intronic chr4:120148631(+) A-I      intronic chr4:120148638(+) A-I      intronic chr4:120148727(+) A-I      intronic chr4:120148746(+) A-I      intronic chr4:120156623(+) A-I      intronic chr4:120182276(+) A-I      intronic chr4:120182290(+) A-I      intronic chr4:120184969(+) A-I      intronic chr4:120184971(+) A-I      intronic chr4:120184972(+) A-I      intronic chr4:120185002(+) A-I      intronic chr4:120148622(+) A-I      intronic chr4:120182377(+) A-I      intronic chr4:120148625(+) A-I      intronic chr4:120148028(+) A-I      intronic chr4:120148736(+) A-I      intronic chr4:120180426(+) A-I      intronic chr4:120185140(+) A-I      intronic chr4:120148562(+) A-I      intronic chr4:120148664(+) A-I      intronic chr4:120148619(+) A-I      intronic chr4:120210043(+) A-I      intronic chr4:120185023(+) A-I      intronic chr4:120146807(+) A-I      intronic chr4:120148705(+) A-I      intronic chr4:120182299(+) A-I      intronic chr4:120148255(+) A-I      intronic chr4:120148101(+) A-I      intronic chr4:120148136(+) A-I      intronic chr4:120148252(+) A-I      intronic chr4:120148197(+) A-I      intronic chr4:120148033(+) A-I      intronic chr4:120148207(+) A-I      intronic chr4:120148628(+) A-I      intronic chr4:120148106(+) A-I      intronic chr4:120145211(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	USP53	chr4:120148010(+) A-I intron -    21960545 chr4:120148050(+) A-I intron -    21960545 chr4:120148052(+) A-I intron -    21960545 chr4:120148106(+) A-I intron -    21960545 chr4:120148197(+) A-I intron -    21960545 chr4:120164094(+) A-I intron -    21960545 chr4:120185765(+) A-I intron -    21960545 chr4:120185847(+) A-I intron -    21960545 chr4:120185924(+) A-I intron -    21960545 chr4:120187312(+) A-I intron -    21960545 chr4:120187318(+) A-I intron -    21960545 chr4:120187491(+) A-I intron -    21960545 chr4:120187492(+) A-I intron -    21960545 chr4:120187573(+) A-I intron -    21960545 chr4:120187576(+) A-I intron -    21960545 chr4:120187635(+) A-I intron -    21960545 chr4:120187661(+) A-I intron -    21960545 chr4:120187705(+) A-I intron -    21960545 chr4:120148052(+) A-G intron -    22484847 chr4:120148252(+) A-G intron -    22484847 chr4:120148255(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	USP53	chr4:120133849-120133850(+) m6A 5'UTR//exon       24981863 chr4:120133991-120133992(+) m6A 5'UTR//exon       24981863 chr4:120160454-120160455(+) Y 5'UTR//exon       26075521 chr4:120160709-120160710(+) m6A 5'UTR       26404942//22608085 chr4:120160781-120160782(+) m6A 5'UTR       24981863//26404942//22608085 chr4:120160789-120160790(+) m6A 5'UTR       24981863//26404942//22608085 chr4:120160808-120160809(+) m6A 5'UTR       24981863//26404942//22608085 chr4:120160828-120160829(+) m6A 5'UTR       24981863//26404942//22608085 chr4:120160838-120160839(+) m6A 5'UTR       24981863//26404942//22608085 chr4:120160898-120160899(+) m6A 5'UTR       24981863//26404942//22608085 chr4:120160940-120160941(+) m6A CDS       22608085 chr4:120189570-120189571(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr4:120190884-120190885(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:120190918-120190919(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:120190926-120190927(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:120190963-120190964(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr4:120192465-120192466(+) m6A 3'UTR//CDS//exon       27773535 chr4:120192514-120192515(+) m6A 3'UTR//CDS//exon       22608085 chr4:120192565-120192566(+) m6A 3'UTR//CDS//exon       27773535//22608085 chr4:120192696-120192697(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr4:120192726-120192727(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr4:120192756-120192757(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr4:120192769-120192770(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085 chr4:120192782-120192783(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085 chr4:120192823-120192824(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:120192838-120192839(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:120192844-120192845(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr4:120193064-120193065(+) m6A 3'UTR//CDS//exon       24209618//24981863//27773535//22608085 chr4:120193119-120193120(+) m6A 3'UTR//CDS//exon       24209618//24981863//26404942//27773535//22608085 chr4:120193175-120193176(+) m6A 3'UTR//CDS//exon       24209618//24981863//27773535//22608085 chr4:120212332-120212333(+) m6A 3'UTR//CDS       24981863 chr4:120213509-120213510(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr4:120213554-120213555(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr4:120213570-120213571(+) m6A 3'UTR//CDS       24981863//27773535//22608085 chr4:120213591-120213592(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120213597-120213598(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120213606-120213607(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120213658-120213659(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:120213707-120213708(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:120213717-120213718(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:120213748-120213749(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:120213769-120213770(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:120213821-120213822(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr4:120213885-120213886(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr4:120213984-120213985(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120214047-120214048(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120214086-120214087(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr4:120214096-120214097(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr4:120214133-120214134(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085 chr4:120214172-120214173(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120214206-120214207(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120214211-120214212(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120214237-120214238(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:120214377-120214378(+) m6A 3'UTR       24981863//22608085 chr4:120214382-120214383(+) m6A 3'UTR       24981863//22608085 chr4:120214424-120214425(+) m6A 3'UTR       24981863//22608085 chr4:120214436-120214437(+) m6A 3'UTR       24981863//22608085 chr4:120214469-120214470(+) m6A 3'UTR       24981863//26404942//22608085 chr4:120214514-120214515(+) m6A 3'UTR       26404942 chr4:120214527-120214528(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	USP53	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-2-5p
Interactor2: USP53

Evidence Support:

Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//VmiReg