Basic Information:

  VIRBase ID:  

VHID00438358

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-2-5p:  MIMAT0002183          EHD3:  NM_014600     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-2-5p	EHD3
miRBase Accession/Entrez ID	MIMAT0002183	30845
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	PAST3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EHD3	chr2:31487574(+) A-I      intronic chr2:31487537(+) A-I      intronic chr2:31487535(+) A-I      intronic chr2:31487575(+) A-I      intronic chr2:31473213(+) A-I      intronic chr2:31460505(+) A-I      intronic chr2:31473308(+) A-I      intronic chr2:31473317(+) A-I      intronic chr2:31465942(+) A-I      intronic chr2:31483030(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EHD3	chr2:31457410-31457411(+) m6A 5'UTR       25456834 chr2:31457424-31457425(+) m6A 5'UTR       25456834 chr2:31457527-31457528(+) m6A CDS       25456834//24981863 chr2:31457567-31457568(+) m6A CDS       25456834 chr2:31483697-31483698(+) m6A CDS       - chr2:31483702-31483703(+) m6A CDS       - chr2:31483714-31483715(+) m6A CDS       - chr2:31484472-31484473(+) m6A CDS       - chr2:31484553-31484554(+) m6A CDS       24209618//24981863 chr2:31489061-31489062(+) m6A CDS       24209618//25456834//24981863//22575960//22608085 chr2:31489292-31489293(+) m6A CDS       24209618//25456834//24981863 chr2:31489582-31489583(+) m6A 3'UTR//CDS       24209618//24981863 chr2:31489661-31489662(+) m6A 3'UTR       24209618//24981863 chr2:31489713-31489714(+) m6A 3'UTR       24209618 chr2:31489953-31489954(+) m6A 3'UTR       24981863//22608085 chr2:31489969-31489970(+) m6A 3'UTR       24981863//22608085 chr2:31490565-31490566(+) m6A 3'UTR       24981863//22608085 chr2:31490628-31490629(+) m6A 3'UTR       25456834//24981863//22608085 chr2:31490638-31490639(+) m6A 3'UTR       25456834//24981863//22608085 chr2:31490675-31490676(+) m6A 3'UTR       24209618//25456834//24981863//22575960//22608085 chr2:31490752-31490753(+) m6A 3'UTR       24209618//25456834//24981863//22575960//22608085 chr2:31490795-31490796(+) m6A 3'UTR       24209618//24981863//22608085 chr2:31490926-31490927(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	EHD3	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-2-5p
Interactor2: EHD3

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).