Basic Information:

  VIRBase ID:  

VHID00438316

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-2-5p:  MIMAT0002183          TRIB2:  NR_027303     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-2-5p	TRIB2
miRBase Accession/Entrez ID	MIMAT0002183	28951
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C5FW//GS3955//TRB2

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TRIB2	chr2:12857468-12857469(+) m6A 5'UTR//exon//intron       25456834//22608085 chr2:12857500-12857501(+) m6A 5'UTR//exon//intron       25456834 chr2:12857920-12857921(+) m6A 5'UTR//intron       24209618//25456834 chr2:12857969-12857970(+) m6A 5'UTR//intron       24209618//25456834 chr2:12857998-12857999(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr2:12858007-12858008(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr2:12858130-12858131(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr2:12858199-12858200(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr2:12858223-12858224(+) m6A 5'UTR//intron       24209618//25456834//24981863//22608085 chr2:12858437-12858438(+) m6A CDS//intron       24981863//22608085 chr2:12858488-12858489(+) m6A CDS//intron       24209618//24981863//22608085 chr2:12858493-12858494(+) m6A CDS//intron       24209618//24981863//22608085 chr2:12858557-12858558(+) m6A CDS//intron       24209618//24981863//22608085 chr2:12858583-12858584(+) m6A CDS//intron       24209618//24981863//22608085 chr2:12858590-12858591(+) m6A CDS//intron       24209618//24981863//22608085 chr2:12858636-12858637(+) m6A CDS//intron       24209618 chr2:12858650-12858651(+) m6A CDS//intron       24209618 chr2:12863484-12863485(+) m6A 5'UTR//CDS       24209618 chr2:12863521-12863522(+) m6A 5'UTR//CDS       25456834//24981863 chr2:12863576-12863577(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12863638-12863639(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12880561-12880562(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12880661-12880662(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12880713-12880714(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12880798-12880799(+) m6A CDS       24209618//25456834//24981863//22575960//22608085 chr2:12880897-12880898(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12880903-12880904(+) m6A CDS       24209618//25456834//24981863//22608085 chr2:12880937-12880938(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr2:12880991-12880992(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr2:12881022-12881023(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr2:12881057-12881058(+) m6A 3'UTR       24209618//25456834//24981863//22608085 chr2:12881171-12881172(+) m6A 3'UTR       24209618//25456834//24981863//22608085 chr2:12881255-12881256(+) m6A 3'UTR       24209618

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TRIB2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-2-5p
Interactor2: TRIB2

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).