Basic Information:

  VIRBase ID:  

VHID00438137

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-2-5p:  MIMAT0002183          ARL6IP1:  NM_015161     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-2-5p	ARL6IP1
miRBase Accession/Entrez ID	MIMAT0002183	23204
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	AIP1//ARL6IP//ARMER//SPG61

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ARL6IP1	chr16:18810528(-) A-I      intronic chr16:18805412(-) A-I      intronic chr16:18811347(-) A-I      intronic chr16:18810571(-) A-I      intronic chr16:18811344(-) A-I      intronic chr16:18806488(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARL6IP1	chr16:18803028-18803029(-) Y 3'UTR       25219674 chr16:18803373-18803374(-) m6A 3'UTR       26404942 chr16:18804355-18804356(-) m6A 3'UTR       22575960 chr16:18804433-18804434(-) m6A 3'UTR       22575960 chr16:18810129-18810130(-) m6A 5'UTR//CDS//exon       22575960 chr16:18810146-18810147(-) m6A 5'UTR//CDS//exon       22575960 chr16:18812583-18812584(-) m6A 5'UTR//intron       22575960 chr16:18812804-18812805(-) m6A 5'UTR//exon       22575960 chr16:18812836-18812837(-) m6A 5'UTR//exon       22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ARL6IP1	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-2-5p
Interactor2: ARL6IP1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//miRanda//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).