Basic Information:

  VIRBase ID:  

VHID00437905

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-2-5p:  MIMAT0002183          TOB1:  NM_001243885     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-2-5p	TOB1
miRBase Accession/Entrez ID	MIMAT0002183	10140
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	APRO5//APRO6//PIG49//TOB//TROB//TROB1

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TOB1	chr17:48940093-48940094(-) m6A 3'UTR       26404942 chr17:48940205-48940206(-) m6A 3'UTR       26404942 chr17:48940588-48940589(-) m6A CDS       24284625//24981863//26404942//27773535//22575960//22608085 chr17:48940989-48940990(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr17:48941003-48941004(-) Y CDS//exon       26075521 chr17:48941057-48941058(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:48941145-48941146(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:48941171-48941172(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:48941184-48941185(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:48941276-48941277(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:48941285-48941286(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr17:48941401-48941402(-) m6A 5'UTR//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr17:48941443-48941444(-) m6A 5'UTR//intron       24284625//24209618//24981863//26404942//27773535//27371828//22608085 chr17:48941448-48941449(-) m6A 5'UTR//intron       24284625//24209618//24981863//26404942//27773535//27371828//22608085 chr17:48941521-48941522(-) m6A 5'UTR//intron       24284625//24209618//24981863//26404942//27773535//27371828//27773536//22608085 chr17:48944886-48944887(-) m6A 5'UTR       24284625//25456834//24981863//27371828 chr17:48945179-48945180(-) m6A 5'UTR       24284625//25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TOB1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-2-5p
Interactor2: TOB1

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).