Basic Information:

  VIRBase ID:  

VHID00437674

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-2-5p:  MIMAT0002183          IFITM1:  NM_003641     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-2-5p	IFITM1
miRBase Accession/Entrez ID	MIMAT0002183	8519
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	9-27//CD225//DSPA2a//IFI17//LEU13

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IFITM1	chr11:315267(+) T-C intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFITM1	chr11:313992-313993(+) m6A 5'UTR//intron       25456834//24981863 chr11:314008-314009(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314036-314037(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314088-314089(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314120-314121(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314134-314135(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314184-314185(+) m6A CDS       24284625//25456834//24981863 chr11:314260-314261(+) m6A CDS       - chr11:314928-314929(+) m6A CDS//exon       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IFITM1	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-2-5p
Interactor2: IFITM1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.