Basic Information:

  VIRBase ID:  

VHID00437275

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-2-5p:  MIMAT0002183          DNAJB9:  NM_012328     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-2-5p	DNAJB9
miRBase Accession/Entrez ID	MIMAT0002183	4189
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ERdj4//MDG-1//MDG1//MST049//MSTP049

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DNAJB9	chr7:108210035-108210036(+) m6A 5'UTR       24981863//27371828//27773536 chr7:108210371-108210372(+) m6A 5'UTR//exon       24981863 chr7:108213350-108213351(+) m6A CDS//intron       24284625//24981863//27773535//22608085 chr7:108213394-108213395(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr7:108213421-108213422(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22608085 chr7:108213486-108213487(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085 chr7:108213507-108213508(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085 chr7:108213513-108213514(+) m6A CDS//intron       24284625//24981863//26404942//27773535//22608085 chr7:108213551-108213552(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:108213577-108213578(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr7:108213698-108213699(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:108213737-108213738(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:108213790-108213791(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:108213858-108213859(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr7:108213872-108213873(+) m6A 3'UTR//intron       24981863//26404942//27773535//22608085 chr7:108213904-108213905(+) m6A 3'UTR//intron       24981863//26404942//27773535//22608085 chr7:108214791-108214792(+) m6A 3'UTR//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	DNAJB9	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-2-5p
Interactor2: DNAJB9

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	miRanda//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).