Basic Information:

  VIRBase ID:  

VHID00437062

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-2-5p:  MIMAT0002183          EIF1AX:  NM_001412     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-2-5p	EIF1AX
miRBase Accession/Entrez ID	MIMAT0002183	1964
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	eIF-1A//eIF-4C//EIF1A//EIF1AP1//EIF4C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EIF1AX	chrX:20156555(-) A-I      intronic chrX:20156535(-) A-I      intronic chrX:20156554(-) A-I      intronic chrX:20156530(-) A-I      intronic chrX:20148247(-) A-I      intronic chrX:20148299(-) A-I      intronic chrX:20148321(-) A-I      intronic chrX:20149680(-) A-I      intronic chrX:20156260(-) A-I      intronic chrX:20149740(-) A-I      intronic chrX:20147507(-) A-I      intronic chrX:20156492(-) A-I      intronic chrX:20149903(-) A-I      intronic chrX:20156465(-) A-I      intronic chrX:20147511(-) A-I      intronic chrX:20147436(-) A-I      intronic chrX:20149902(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EIF1AX	chrX:20147511(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EIF1AX	chrX:20143387-20143388(-) m6A 3'UTR       24981863 chrX:20146417-20146418(-) m6A 3'UTR       24981863 chrX:20148710-20148711(-) m6A CDS       27773535 chrX:20152081-20152082(-) m6A CDS       27773535 chrX:20152105-20152106(-) m6A CDS       27773535 chrX:20154386-20154387(-) Y intron       26075521 chrX:20156681-20156682(-) m6A CDS//intron       24981863//28052920//27773535//27371828//22575960 chrX:20156724-20156725(-) m6A CDS//intron       24981863//28052920//27773535//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	EIF1AX	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-2-5p
Interactor2: EIF1AX

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	cRep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).