Detail Information

Basic Information:


  VIRBase ID:  

VHID00436866

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8808

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      Predicted binding sites in PRIdictor:   RELA:      
Binding sites in PDB
PDB 1NFI//2LSP//2N22//2O61//3GUT//3QXY//3RC0//4KV1//4KV4

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-1-5p RELA
miRBase
Accession/Entrez ID		 MIMAT0002182 5970
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA protein
Alias - CMCU//NFKB3//p65

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RELA
chr11:65428693(-) A-I      intronic
chr11:65428725(-) A-I      intronic
chr11:65428675(-) A-I      intronic
chr11:65428749(-) A-I      intronic
chr11:65428674(-) A-I      intronic
chr11:65428789(-) A-I      intronic
chr11:65428714(-) A-I      intronic
chr11:65428266(-) A-I      intronic
chr11:65428244(-) A-I      intronic
chr11:65428388(-) A-I      intronic
chr11:65428701(-) A-I      intronic
chr11:65428253(-) A-I      intronic
chr11:65428375(-) A-I      intronic
chr11:65428423(-) A-I      intronic
chr11:65428779(-) A-I      intronic
chr11:65428362(-) A-I      intronic
chr11:65428639(-) A-I      intronic
chr11:65428320(-) A-I      intronic
chr11:65428686(-) A-I      intronic
chr11:65428773(-) A-I      intronic
chr11:65428717(-) A-I      intronic
chr11:65428265(-) A-I      intronic
chr11:65428352(-) A-I      intronic
chr11:65428336(-) A-I      intronic
chr11:65428453(-) A-I      intronic
chr11:65428748(-) A-I      intronic
chr11:65428697(-) A-I      intronic
chr11:65428671(-) A-I      intronic
chr11:65428386(-) A-I      intronic
chr11:65428787(-) A-I      intronic
chr11:65428345(-) A-I      intronic
chr11:65428770(-) A-I      intronic
chr11:65428666(-) A-I      intronic
chr11:65428267(-) A-I      intronic
chr11:65428762(-) A-I      intronic
chr11:65428637(-) A-I      intronic
chr11:65428579(-) A-I      intronic
chr11:65428621(-) A-I      intronic
chr11:65428598(-) A-I      intronic
chr11:65428670(-) A-I      intronic
chr11:65428566(-) A-I      intronic
chr11:65428578(-) A-I      intronic
chr11:65428574(-) A-I      intronic
chr11:65428663(-) A-I      intronic
chr11:65428447(-) A-I      intronic
chr11:65428771(-) A-I      intronic
chr11:65428716(-) A-I      intronic
chr11:65428740(-) A-I      intronic
chr11:65428342(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RELA
chr11:65428663(-) A-I intron -    21960545   //22327324
chr11:65428670(-) A-I intron -    22327324
chr11:65428579(-) A-I intron -    21960545
chr11:65428598(-) A-I intron -    21960545
chr11:65428666(-) A-I intron -    21960545
chr11:65428267(-) A-G intron -    22484847
chr11:65428352(-) A-G intron -    22484847
chr11:65428386(-) A-G intron -    22484847
chr11:65428447(-) A-G intron -    22484847
chr11:65428532(-) C-T intron -    22484847
chr11:65428663(-) A-G intron -    22484847
chr11:65428666(-) A-G intron -    22484847
chr11:65428670(-) A-G intron -    22484847
chr11:65428779(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RELA
chr11:65421095-65421096(-) m6A 3'UTR       24284625//24981863//28052920//27773535//27371828//22608085
chr11:65421117-65421118(-) m6A 3'UTR       24284625//24981863//28052920//27773535//27371828//22608085
chr11:65421134-65421135(-) m6A 3'UTR       24284625//24981863//28052920//27773535//27371828//22608085
chr11:65421242-65421243(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr11:65421295-65421296(-) m6A 3'UTR       24284625//24981863
chr11:65421882-65421883(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:65421888-65421889(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:65421906-65421907(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:65422068-65422069(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr11:65422110-65422111(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//27371828//22575960
chr11:65422128-65422129(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//27371828//22575960
chr11:65422158-65422159(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//27371828
chr11:65422638-65422639(-) m6A 3'UTR//intron       27773535//27371828
chr11:65422643-65422644(-) m6A 3'UTR//intron       27773535//27371828
chr11:65422668-65422669(-) m6A 3'UTR//intron       27773535//27371828
chr11:65422751-65422752(-) m6A 3'UTR//intron       25456834//27371828
chr11:65422771-65422772(-) m6A 3'UTR//intron       25456834//27371828
chr11:65422836-65422837(-) m6A 3'UTR//intron       24284625
chr11:65422889-65422890(-) m6A 3'UTR//intron       -
chr11:65422984-65422985(-) m6A 3'UTR//intron       27371828
chr11:65423027-65423028(-) m6A 3'UTR//intron       27371828
chr11:65423065-65423066(-) m6A CDS//intron       27371828
chr11:65423085-65423086(-) m6A CDS//intron       27371828
chr11:65423340-65423341(-) m1A 3'UTR//CDS//exon//intron       26863196
chr11:65423361-65423362(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr11:65423370-65423371(-) m6A 3'UTR//CDS//exon//intron       27773535
chr11:65425858-65425859(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535
chr11:65425874-65425875(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535
chr11:65425944-65425945(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535
chr11:65425966-65425967(-) m6A 3'UTR//CDS//exon//intron       27773535
chr11:65426247-65426248(-) m6A 3'UTR//CDS//exon//intron       27773535
chr11:65426253-65426254(-) m6A 3'UTR//CDS//exon//intron       27773535
chr11:65427195-65427196(-) m6A 3'UTR//CDS//exon       27773535
chr11:65427243-65427244(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535
chr11:65427583-65427584(-) m6A exon//intron       27773535//27371828
chr11:65427615-65427616(-) m6A 3'UTR//CDS//exon//intron       27773535//27371828
chr11:65427647-65427648(-) m6A 3'UTR//CDS//exon//intron       27773535//27371828
chr11:65427677-65427678(-) m6A 3'UTR//CDS//exon//intron       27773535//27371828
chr11:65427707-65427708(-) m6A exon//intron       27773535//27371828
chr11:65427715-65427716(-) m6A exon//intron       27773535//27371828
chr11:65427840-65427841(-) m6A exon//intron       27773535
chr11:65427981-65427982(-) m6A exon//intron       27773535
chr11:65427999-65428000(-) m6A exon//intron       27773535
chr11:65428037-65428038(-) m6A exon//intron       27773535
chr11:65429172-65429173(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863
chr11:65429211-65429212(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863
chr11:65429253-65429254(-) m6A CDS//exon//intron       24284625//24981863
chr11:65429281-65429282(-) m6A CDS//exon//intron       24284625//24981863
chr11:65429288-65429289(-) m6A CDS//exon//intron       24284625//24981863
chr11:65429309-65429310(-) m6A CDS//exon//intron       24284625//24981863
chr11:65429366-65429367(-) m6A exon//intron       24284625//24981863
chr11:65429374-65429375(-) m6A exon//intron       24284625//24981863//27773535
chr11:65429424-65429425(-) m6A CDS//exon//intron       24284625//24981863//27773535
chr11:65429674-65429675(-) m6A 5'UTR//CDS//exon//intron       24209618//24981863//27371828
chr11:65430311-65430312(-) m6A 5'UTR//exon       24209618//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate RELA
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Human embryonic kidney cell line (HEK-293T)     30844390
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-1-5p
Interactor2: RELA

Evidence Support:


Strong-Evidence Northern blot//RT-PCR
Support Database VIRmiRNA

References:


PMID 20081837 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line BCP-1 cells//HEK293T cells Interactor2 expression None
Description Expression of miR-K1 is sufficient to rescue the NF-kaapaB activity and inhibit viral lytic replication while inhibition of miR-K1 in KSHV-infected PEL cells has the opposite effects. Thus, KSHV encodes a miR to control viral replication by activating NF-kappaB pathway. These results illustrate an important role for KSHV miRs in regulating viral latency and lytic replication by manipulating a host survival pathway.

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