Basic Information:

  VIRBase ID:  

VHID00436466

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-5p:  MIMAT0002182          PXT1:  NM_152990     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-1-5p	PXT1
miRBase Accession/Entrez ID	MIMAT0002182	222659
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	STEPP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PXT1	chr6:36397421(-) A-I      intronic chr6:36397420(-) A-I      intronic chr6:36397875(-) A-I      intronic chr6:36397876(-) A-I      intronic chr6:36397897(-) A-I      intronic chr6:36408350(-) A-I      intronic chr6:36407295(-) A-I      intronic chr6:36397902(-) A-I      intronic chr6:36407209(-) A-I      intronic chr6:36407252(-) A-I      intronic chr6:36407241(-) A-I      intronic chr6:36407226(-) A-I      intronic chr6:36407223(-) A-I      intronic chr6:36406395(-) A-I      intronic chr6:36396996(-) A-I      intronic chr6:36397407(-) A-I      intronic chr6:36397470(-) A-I      intronic chr6:36397464(-) A-I      intronic chr6:36397458(-) A-I      intronic chr6:36397455(-) A-I      intronic chr6:36397447(-) A-I      intronic chr6:36371430(-) A-I      intronic chr6:36379994(-) A-I      intronic chr6:36371453(-) A-I      intronic chr6:36362819(-) A-I      intronic chr6:36361384(-) A-I      intronic chr6:36379980(-) A-I      intronic chr6:36379981(-) A-I      intronic chr6:36405455(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PXT1	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-1-5p
Interactor2: PXT1

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	PARalyzer
Support Database	ViRBase//VIRmiRNA

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VIRmiRNA	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.