Detail Information

Basic Information:


  VIRBase ID:  

VHID00435100

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.8925

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-5p:           MTUS1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-1-5p MTUS1
miRBase
Accession/Entrez ID		 MIMAT0002182 57509
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - ATBP//ATIP//ATIP3//ICIS//MP44//MTSG1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MTUS1
chr8:17539927(-) A-I      intronic
chr8:17655872(-) A-I      intronic
chr8:17654429(-) A-I      intronic
chr8:17654428(-) A-I      intronic
chr8:17648279(-) A-I      intronic
chr8:17643603(-) A-I      intronic
chr8:17643566(-) A-I      intronic
chr8:17643549(-) A-I      intronic
chr8:17643479(-) A-I      intronic
chr8:17513999(-) A-I      intronic
chr8:17601984(-) A-I      intronic
chr8:17562629(-) A-I      intronic
chr8:17515643(-) A-I      intronic
chr8:17528249(-) A-I      intronic
chr8:17537190(-) A-I      intronic
chr8:17562603(-) A-I      intronic
chr8:17562585(-) A-I      intronic
chr8:17556884(-) A-I      intronic
chr8:17551673(-) A-I      intronic
chr8:17539993(-) A-I      intronic
chr8:17539989(-) A-I      intronic
chr8:17539964(-) A-I      intronic
chr8:17539853(-) A-I      intronic
chr8:17646706(-) A-I      intronic
chr8:17567896(-) A-I      intronic
chr8:17567897(-) A-I      intronic
chr8:17567898(-) A-I      intronic
chr8:17567927(-) A-I      intronic
chr8:17567930(-) A-I      intronic
chr8:17567940(-) A-I      intronic
chr8:17567943(-) A-I      intronic
chr8:17528183(-) A-I      intronic
chr8:17528222(-) A-I      intronic
chr8:17528160(-) A-I      intronic
chr8:17528220(-) A-I      intronic
chr8:17528246(-) A-I      intronic
chr8:17648309(-) A-I      intronic
chr8:17648292(-) A-I      intronic
chr8:17648270(-) A-I      intronic
chr8:17537071(-) A-I      intronic
chr8:17531737(-) A-I      intronic
chr8:17620683(-) A-I      intronic
chr8:17646702(-) A-I      intronic
chr8:17640543(-) A-I      intronic
chr8:17640421(-) A-I      intronic
chr8:17567327(-) A-I      intronic
chr8:17539915(-) A-I      intronic
chr8:17537927(-) A-I      intronic
chr8:17517038(-) A-I      intronic
chr8:17620719(-) A-I      intronic
chr8:17620702(-) A-I      intronic
chr8:17620694(-) A-I      intronic
chr8:17556861(-) A-I      intronic
chr8:17556838(-) A-I      intronic
chr8:17556835(-) A-I      intronic
chr8:17556829(-) A-I      intronic
chr8:17556824(-) A-I      intronic
chr8:17556823(-) A-I      intronic
chr8:17531702(-) A-I      intronic
chr8:17537228(-) A-I      intronic
chr8:17531125(-) A-I      intronic
chr8:17556812(-) A-I      intronic
chr8:17539845(-) A-I      intronic
chr8:17537078(-) A-I      intronic
chr8:17537079(-) A-I      intronic
chr8:17537188(-) A-I      intronic
chr8:17537189(-) A-I      intronic
chr8:17537710(-) A-I      intronic
chr8:17537770(-) A-I      intronic
chr8:17537205(-) A-I      intronic
chr8:17538481(-) A-I      intronic
chr8:17538511(-) A-I      intronic
chr8:17538724(-) A-I      intronic
chr8:17539808(-) A-I      intronic
chr8:17539833(-) A-I      intronic
chr8:17655953(-) A-I      intronic
chr8:17648427(-) A-I      intronic
chr8:17654569(-) A-I      intronic
chr8:17654611(-) A-I      intronic
chr8:17521229(-) A-I      intronic
chr8:17521216(-) A-I      intronic
chr8:17515724(-) A-I      intronic
chr8:17515719(-) A-I      intronic
chr8:17515685(-) A-I      intronic
chr8:17515675(-) A-I      intronic
chr8:17515623(-) A-I      intronic
chr8:17514419(-) A-I      intronic
chr8:17515789(-) A-I      intronic
chr8:17656113(-) A-I      intronic
chr8:17551912(-) A-I      intronic
chr8:17537191(-) A-I      intronic
chr8:17537800(-) A-I      intronic
chr8:17556852(-) A-I      intronic
chr8:17515713(-) A-I      intronic
chr8:17577643(-) A-I      intronic
chr8:17515253(-) A-I      intronic
chr8:17531763(-) A-I      intronic
chr8:17531146(-) A-I      intronic
chr8:17539862(-) A-I      intronic
chr8:17531160(-) A-I      intronic
chr8:17538571(-) A-I      intronic
chr8:17531690(-) A-I      intronic
chr8:17531781(-) A-I      intronic
chr8:17537793(-) A-I      intronic
chr8:17531120(-) A-I      intronic
chr8:17537149(-) A-I      intronic
chr8:17517637(-) A-I      intronic
chr8:17514401(-) A-I      intronic
chr8:17508107(-) A-I      intronic
chr8:17537728(-) A-I      intronic
chr8:17538722(-) A-I      intronic
chr8:17569942(-) A-I      intronic
chr8:17598438(-) A-I      intronic
chr8:17513974(-) A-I      intronic
chr8:17587806(-) A-I      intronic
chr8:17515741(-) A-I      intronic
chr8:17551681(-) A-I      intronic
chr8:17538694(-) A-I      intronic
chr8:17539917(-) A-I      intronic
chr8:17537810(-) A-I      intronic
chr8:17537729(-) A-I      intronic
chr8:17541044(-) A-I      intronic
chr8:17515714(-) A-I      intronic
chr8:17531231(-) A-I      intronic
chr8:17560986(-) A-I      intronic
chr8:17531068(-) A-I      intronic
chr8:17596600(-) A-I      intronic
chr8:17595178(-) A-I      intronic
chr8:17515780(-) A-I      intronic
chr8:17569970(-) A-I      intronic
chr8:17515694(-) A-I      intronic
chr8:17538497(-) A-I      intronic
chr8:17513977(-) A-I      intronic
chr8:17531236(-) A-I      intronic
chr8:17539879(-) A-I      intronic
chr8:17540767(-) A-I      intronic
chr8:17537284(-) A-I      intronic
chr8:17513857(-) A-I      intronic
chr8:17540592(-) A-I      intronic
chr8:17537807(-) A-I      intronic
chr8:17599724(-) A-I      intronic
chr8:17515671(-) A-I      intronic
chr8:17528184(-) A-I      intronic
chr8:17537285(-) A-I      intronic
chr8:17538581(-) A-I      intronic
chr8:17537184(-) A-I      intronic
chr8:17538636(-) A-I      intronic
chr8:17515723(-) A-I      intronic
chr8:17531250(-) A-I      intronic
chr8:17539768(-) A-I      intronic
chr8:17506703(-) A-I      intronic
chr8:17538575(-) A-I      intronic
chr8:17531817(-) A-I      intronic
chr8:17515765(-) A-I      intronic
chr8:17617715(-) A-I      intronic
chr8:17541056(-) A-I      intronic
chr8:17531846(-) A-I      intronic
chr8:17539859(-) A-I      intronic
chr8:17538639(-) A-I      intronic
chr8:17513925(-) A-I      intronic
chr8:17595164(-) A-I      intronic
chr8:17538559(-) A-I      intronic
chr8:17531245(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MTUS1
chr8:17501477-17501478(-) m6A 3'UTR//exon       26404942
chr8:17501496-17501497(-) m6A 3'UTR//exon       26404942
chr8:17501519-17501520(-) m6A 3'UTR//exon       26404942
chr8:17501969-17501970(-) m6A 3'UTR//exon       26404942
chr8:17502249-17502250(-) m6A 3'UTR//exon       26404942
chr8:17502306-17502307(-) m6A 3'UTR//exon       24981863//26404942
chr8:17502322-17502323(-) m6A 3'UTR//exon       24981863//26404942
chr8:17502384-17502385(-) m6A 3'UTR//exon       24981863//26404942//27773535
chr8:17502415-17502416(-) m6A 3'UTR//exon       24981863//26404942//27773535
chr8:17502583-17502584(-) m6A 3'UTR//exon       27773535
chr8:17502605-17502606(-) m6A 3'UTR//exon       27773535
chr8:17502693-17502694(-) m6A 3'UTR//exon       27773535
chr8:17503063-17503064(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17503115-17503116(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17503257-17503258(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17503270-17503271(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17503276-17503277(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17503379-17503380(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17503413-17503414(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17503534-17503535(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17503548-17503549(-) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085
chr8:17504511-17504512(-) m6A 3'UTR//CDS//exon       27773535
chr8:17504583-17504584(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr8:17507357-17507358(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr8:17507382-17507383(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr8:17507396-17507397(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr8:17507444-17507445(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr8:17509117-17509118(-) m6A exon//intron       24981863//27773535
chr8:17509270-17509271(-) m6A exon//intron       24981863//27773535
chr8:17510727-17510728(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr8:17512022-17512023(-) m6A exon//intron       24981863
chr8:17512042-17512043(-) m6A exon//intron       24981863
chr8:17512109-17512110(-) m6A 3'UTR//CDS//exon       24981863
chr8:17513420-17513421(-) m6A 3'UTR//CDS//exon       26404942//27773535
chr8:17513478-17513479(-) m6A 3'UTR//CDS//exon       26404942//27773535
chr8:17513520-17513521(-) m6A 3'UTR//CDS//exon       26404942//27773535
chr8:17521549-17521550(-) m6A exon//intron       27773535
chr8:17521567-17521568(-) m6A exon//intron       27773535
chr8:17541933-17541934(-) m6A 3'UTR//CDS//exon       26404942
chr8:17541946-17541947(-) m6A 3'UTR//CDS//exon       26404942
chr8:17541970-17541971(-) m6A 3'UTR//CDS//exon       26404942
chr8:17542000-17542001(-) m6A 3'UTR//CDS//exon       26404942
chr8:17548850-17548851(-) m6A exon//intron       27773535
chr8:17549503-17549504(-) m6A exon//intron       27773535
chr8:17554887-17554888(-) m6A 5'UTR//intron       -
chr8:17554948-17554949(-) m6A 5'UTR//intron       24981863
chr8:17555070-17555071(-) m6A 5'UTR//intron       -
chr8:17555146-17555147(-) m6A 5'UTR//intron       -
chr8:17566319-17566320(-) m6A exon//intron       -
chr8:17601183-17601184(-) m6A CDS//exon       27773535
chr8:17601292-17601293(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611251-17611252(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611270-17611271(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611282-17611283(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611296-17611297(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611437-17611438(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611506-17611507(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611573-17611574(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611596-17611597(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611625-17611626(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611650-17611651(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611665-17611666(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611672-17611673(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17611707-17611708(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611717-17611718(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611799-17611800(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611804-17611805(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611827-17611828(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611888-17611889(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611898-17611899(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611919-17611920(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17611928-17611929(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085
chr8:17612014-17612015(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612048-17612049(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612086-17612087(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612110-17612111(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612154-17612155(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612189-17612190(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612196-17612197(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612219-17612220(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612298-17612299(-) m6A CDS//exon       24981863//26404942//27773535//22608085
chr8:17612353-17612354(-) m6A CDS//exon       24981863//26404942//27773535//22608085
chr8:17612451-17612452(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612470-17612471(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612597-17612598(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612627-17612628(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612655-17612656(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612691-17612692(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17612838-17612839(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr8:17612843-17612844(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr8:17612876-17612877(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr8:17613138-17613139(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17613182-17613183(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17613203-17613204(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17613270-17613271(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr8:17613392-17613393(-) m6A 5'UTR//exon       24284625//24981863//27773535//22608085
chr8:17613396-17613397(-) m6A 5'UTR//exon       24981863//26404942//27773535//22608085
chr8:17613405-17613406(-) m6A 5'UTR//exon       24981863//26404942//27773535//22608085
chr8:17613426-17613427(-) m6A 5'UTR//exon       24981863//26404942//27773535
chr8:17613433-17613434(-) m6A 5'UTR//exon       24981863//26404942//27773535
chr8:17613466-17613467(-) m6A 5'UTR//exon       24981863
chr8:17658300-17658301(-) m6A 5'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate MTUS1
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-1-5p
Interactor2: MTUS1

Evidence Support:


Strong-Evidence 3'UTR indicator assay
Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VIRmiRNA//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells//BC-3 cells Interactor2 expression None
Description We focused this analysis mostly on 3'UTRs of mRNAs encoding proteins with functions of potential relevance to KSHV biology and pathogenesis (Table S11). Thirty-six combinations of 3'UTR indicators and KSHV miRNAs with PAR-CLIP interactions were tested for regulation. Nine of these interactions were independently also predicted by microarray analysis of the BJAB cell pools expressing miR-K1, miR-K4-3p, or miR-K11 described above (i.e. for miR-K1: NMI, RAD21, BCL11A, RFXAP; for miR-K4-3p: TPD52, GRB2, MCC, YWHAB; for miR-K11: WEE1). Targets were representative of the full range of seed match types observed in the libraries (Tables S6 and S11).

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