Detail Information

Basic Information:


  VIRBase ID:  

VHID00434776

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-5p:           ZNF770:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-1-5p ZNF770
miRBase
Accession/Entrez ID		 MIMAT0002182 54989
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - PRO1914

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ZNF770
chr15:35272815(-) A-I      3'UTR
chr15:35272821(-) A-I      3'UTR
chr15:35272786(-) A-I      3'UTR
chr15:35272812(-) A-I      3'UTR
chr15:35272794(-) A-I      3'UTR
chr15:35272969(-) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZNF770
chr15:35270763-35270764(-) m6A 3'UTR       27773535
chr15:35271583-35271584(-) m6A 3'UTR       24981863
chr15:35271594-35271595(-) m6A 3'UTR       24981863
chr15:35271674-35271675(-) m6A 3'UTR       24981863
chr15:35274013-35274014(-) m6A CDS       22608085
chr15:35274069-35274070(-) m6A CDS       22608085
chr15:35274075-35274076(-) m6A CDS       22608085
chr15:35274096-35274097(-) m6A CDS       22608085
chr15:35274138-35274139(-) m6A CDS       22608085
chr15:35274159-35274160(-) m6A CDS       22608085
chr15:35274168-35274169(-) m6A CDS       22608085
chr15:35274222-35274223(-) m6A CDS       22608085
chr15:35274235-35274236(-) m6A CDS       22608085
chr15:35274319-35274320(-) m6A CDS       24981863//22608085
chr15:35274355-35274356(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274422-35274423(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274446-35274447(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:35274455-35274456(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:35274462-35274463(-) m6A CDS       24284625//24981863//27773535//27371828//22608085
chr15:35274485-35274486(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274498-35274499(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274635-35274636(-) m6A CDS       24981863
chr15:35274930-35274931(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35274945-35274946(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr15:35274993-35274994(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr15:35275113-35275114(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr15:35275299-35275300(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr15:35275319-35275320(-) m6A CDS       24284625//24209618//24981863//28052920//27773535//27371828//22575960//22608085
chr15:35275352-35275353(-) m6A CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr15:35275440-35275441(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr15:35275448-35275449(-) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr15:35275523-35275524(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35275564-35275565(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35275575-35275576(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35275621-35275622(-) m6A CDS       24284625//24981863//27773535//22608085
chr15:35275671-35275672(-) m6A 5'UTR       24284625//24981863//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ZNF770
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-1-5p
Interactor2: ZNF770

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence cRep//miRanda//Targetscan
Support Database RepTar//ViRBase//VmiReg

References:


PMID 22174674 Target region None
Source RepTar//ViRBase//VmiReg Interactor1 expression None
Tissue or cell line DG-75 cells Interactor2 expression Downregulation
Description As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).

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