Detail Information

Basic Information:


  VIRBase ID:  

VHID00434671

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-5p:           ANLN:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-1-5p ANLN
miRBase
Accession/Entrez ID		 MIMAT0002182 54443
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - FSGS8//scra//Scraps

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ANLN
chr7:36452199(+) A-I      intronic
chr7:36472490(+) A-I      intronic
chr7:36468956(+) A-I      intronic
chr7:36474377(+) A-I      intronic
chr7:36474353(+) A-I      intronic
chr7:36452198(+) A-I      intronic
chr7:36474326(+) A-I      intronic
chr7:36474321(+) A-I      intronic
chr7:36441138(+) A-I      intronic
chr7:36469044(+) A-I      intronic
chr7:36469058(+) A-I      intronic
chr7:36487679(+) A-I      intronic
chr7:36441814(+) A-I      intronic
chr7:36442606(+) A-I      intronic
chr7:36442632(+) A-I      intronic
chr7:36442667(+) A-I      intronic
chr7:36487685(+) A-I      intronic
chr7:36443266(+) A-I      intronic
chr7:36443327(+) A-I      intronic
chr7:36452166(+) A-I      intronic
chr7:36452171(+) A-I      intronic
chr7:36474336(+) A-I      intronic
chr7:36455840(+) A-I      intronic
chr7:36487820(+) A-I      intronic
chr7:36471552(+) A-I      intronic
chr7:36442605(+) A-I      intronic
chr7:36474292(+) A-I      intronic
chr7:36483692(+) A-I      intronic
chr7:36471700(+) A-I      intronic
chr7:36487724(+) A-I      intronic
chr7:36483737(+) A-I      intronic
chr7:36474449(+) A-I      intronic
chr7:36441048(+) A-I      intronic
chr7:36441087(+) A-I      intronic
chr7:36471563(+) A-I      intronic
chr7:36478005(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ANLN
chr7:36478089(+) T-C intron -    22484847
chr7:36483737(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ANLN
chr7:36429500-36429501(+) m6A 5'UTR       24284625//25456834//24981863//22575960
chr7:36429533-36429534(+) m6A 5'UTR       24284625//24981863//22575960
chr7:36429554-36429555(+) m6A 5'UTR       24284625//24981863//22575960
chr7:36429569-36429570(+) m6A 5'UTR       24981863//22575960
chr7:36429595-36429596(+) m6A 5'UTR       24981863//22575960
chr7:36438910-36438911(+) Am CDS       -
chr7:36445967-36445968(+) m6A CDS//exon       22608085
chr7:36445972-36445973(+) m6A CDS//exon       22608085
chr7:36445985-36445986(+) m6A CDS//exon       22608085
chr7:36446041-36446042(+) Y CDS//exon       26075521
chr7:36447547-36447548(+) m6A 3'UTR//CDS//exon       27773535
chr7:36450127-36450128(+) m6A 3'UTR//CDS//exon       24981863//27773535
chr7:36450174-36450175(+) m6A 3'UTR//CDS//exon       24981863//27773535
chr7:36450214-36450215(+) m6A 3'UTR//CDS//exon       24981863//27773535
chr7:36450269-36450270(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr7:36450681-36450682(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr7:36450743-36450744(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr7:36450756-36450757(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr7:36450766-36450767(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr7:36450771-36450772(+) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr7:36455369-36455370(+) m6A 3'UTR//CDS//intron       24981863//27773535
chr7:36455398-36455399(+) m6A 3'UTR//CDS//intron       24981863//27773535
chr7:36455417-36455418(+) m6A 3'UTR//CDS//intron       24981863//27773535
chr7:36455454-36455455(+) m6A 3'UTR//CDS//intron       24981863//27773535
chr7:36455485-36455486(+) m6A 3'UTR//CDS//intron       24981863//27773535
chr7:36456751-36456752(+) m6A CDS//exon//intron       24981863//27773535//22575960
chr7:36456775-36456776(+) m6A CDS//intron       24981863//27773535//22575960
chr7:36458949-36458950(+) m6A CDS//intron       24981863//27773535//22575960
chr7:36459005-36459006(+) Am CDS//intron       -
chr7:36459009-36459010(+) m6A CDS//intron       24981863//27773535//22575960
chr7:36459064-36459065(+) m6A CDS//intron       24981863//27773535//22575960
chr7:36459797-36459798(+) m6A CDS//intron       22575960
chr7:36459811-36459812(+) m6A CDS//intron       22575960
chr7:36459839-36459840(+) m6A CDS//intron       22575960
chr7:36459858-36459859(+) m6A CDS//intron       22575960
chr7:36460340-36460341(+) m6A CDS//intron       27773535//22575960
chr7:36461467-36461468(+) m6A CDS//intron       27773535//22575960
chr7:36461495-36461496(+) m6A CDS//intron       27773535//22575960
chr7:36461545-36461546(+) m6A CDS//intron       24981863//27773535//22575960
chr7:36461584-36461585(+) m6A CDS//intron       24981863//27773535//22575960
chr7:36462252-36462253(+) m6A CDS//intron       24981863//27773535//22575960
chr7:36462293-36462294(+) m6A CDS//intron       24981863//27773535//22575960
chr7:36464336-36464337(+) m6A CDS       24981863
chr7:36489323-36489324(+) m6A CDS//exon       -
chr7:36489405-36489406(+) m6A CDS//exon       -
chr7:36489427-36489428(+) m6A CDS//exon       -
chr7:36492688-36492689(+) m6A 3'UTR//exon       27773535
chr7:36492712-36492713(+) m6A 3'UTR//exon       27773535
chr7:36492777-36492778(+) m6A 3'UTR//exon       27773535
chr7:36492798-36492799(+) m6A 3'UTR//exon       27773535
chr7:36493102-36493103(+) m6A 3'UTR//exon       27773535
chr7:36493118-36493119(+) m6A 3'UTR//exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ANLN
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-1-5p
Interactor2: ANLN

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Targetscan
Support Database ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells//BC-3 cells//BJAB cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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