Detail Information

Basic Information:


  VIRBase ID:  

VHID00434644

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9136

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-5p:           BCL11A:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-1-5p BCL11A
miRBase
Accession/Entrez ID		 MIMAT0002182 53335
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - BCL11A-L//BCL11a-M//BCL11A-S//BCL11A-XL//CTIP1//DILOS//EVI9//HBFQTL5//ZNF856

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BCL11A
chr2:60716170(-) A-I      intronic
chr2:60716181(-) A-I      intronic
chr2:60715992(-) A-I      intronic
chr2:60715991(-) A-I      intronic
chr2:60716032(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BCL11A
chr2:60718824(-) C-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BCL11A
chr2:60679416-60679417(-) m6A 3'UTR       -
chr2:60679454-60679455(-) m6A 3'UTR       -
chr2:60679487-60679488(-) m6A 3'UTR       -
chr2:60679503-60679504(-) m6A 3'UTR       -
chr2:60679511-60679512(-) m6A 3'UTR       -
chr2:60687402-60687403(-) m6A 3'UTR//exon//intron       -
chr2:60687410-60687411(-) m6A 3'UTR//exon//intron       -
chr2:60687418-60687419(-) m6A 3'UTR//exon//intron       -
chr2:60687546-60687547(-) m6A CDS//exon//intron       24981863//22608085
chr2:60687595-60687596(-) m6A CDS//exon//intron       24209618//25456834//24981863//22608085
chr2:60687788-60687789(-) m6A CDS//exon//intron       24209618//25456834//24981863//27371828//22608085
chr2:60688006-60688007(-) m6A 3'UTR//CDS//exon//intron       25456834//24981863//27773536//22608085
chr2:60688013-60688014(-) m6A 3'UTR//CDS//exon//intron       25456834//24981863//27773536//22608085
chr2:60688262-60688263(-) m6A 3'UTR//CDS//exon//intron       24209618//25456834//24981863//28052920//27371828//27773536//22608085
chr2:60688283-60688284(-) m6A 3'UTR//CDS//exon//intron       24209618//25456834//24981863//28052920//27371828//27773536//22608085
chr2:60688298-60688299(-) m6A 3'UTR//CDS//exon//intron       24209618//25456834//24981863//28052920//27371828//27773536//22608085
chr2:60688466-60688467(-) m6A 3'UTR//CDS//exon//intron       24209618//25456834//24981863//27371828//27773536//22608085
chr2:60688511-60688512(-) m6A 3'UTR//CDS//exon//intron       24209618//25456834//24981863//27371828//27773536//22608085
chr2:60688699-60688700(-) m6A 3'UTR//CDS//exon//intron       27371828//27773536
chr2:60689072-60689073(-) m6A CDS//exon//intron       24209618//25456834//24981863//27371828//27773536//22608085
chr2:60689092-60689093(-) m6A CDS//exon//intron       24209618//25456834//24981863//27371828//27773536//22608085
chr2:60689222-60689223(-) m6A CDS//exon//intron       24209618//25456834//24981863//27371828//22608085
chr2:60689233-60689234(-) m6A CDS//exon//intron       24209618//25456834//24981863//27371828//22608085
chr2:60689345-60689346(-) m6A CDS//exon//intron       25456834//24981863//22608085
chr2:60689398-60689399(-) m6A CDS//exon//intron       25456834//24981863//22608085
chr2:60689440-60689441(-) m6A 3'UTR//CDS//exon       -
chr2:60689474-60689475(-) m6A 3'UTR//CDS//exon       -
chr2:60689518-60689519(-) m6A 3'UTR//CDS//exon       -
chr2:60771470-60771471(-) m6A exon//intron       -
chr2:60773115-60773116(-) m6A CDS//exon       25456834//24981863
chr2:60773121-60773122(-) m6A CDS//exon       25456834//24981863
chr2:60773283-60773284(-) m6A CDS//exon       24284625//24209618//24981863//27371828//22608085
chr2:60773314-60773315(-) m6A CDS//exon       24284625//24209618//24981863//22608085
chr2:60773329-60773330(-) m6A CDS       24284625//24981863//22608085
chr2:60773395-60773396(-) m6A 5'UTR//CDS       24284625//24981863//22608085
chr2:60773400-60773401(-) m6A 5'UTR//CDS       24284625//24981863//22608085
chr2:60780381-60780382(-) m6A CDS       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate BCL11A
Exosome Blood     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-1-5p
Interactor2: BCL11A

Evidence Support:


Strong-Evidence 3'UTR indicator assay
Weak-Evidence Microarray//PAR-CLIP
Prediction-Evidence cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database RepTar//ViRBase//VIRmiRNA//VmiReg

References:


[1]PMID 23170179 Target region 3'UTR
Source RepTar//ViRBase Interactor1 expression None
Tissue or cell line BC-1 cells//BC-3 cells//BJAB cells Interactor2 expression Downregulation
Description Here,we explore the similarities and differences in the functions of miRNA targets from the limited number of experimentally validated miRNA targets and the larger number of targets predicted by recent reports using high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation(HITS-CLIP and PAR-CLIP) (Table 2).Table 2 Validated targets from high-throughput studies. Shown are cellular targets identified by photoactivatable ribonucleoside enhanced crosslinking and immunoprecipitation(PAR-CLIP), High-throughput sequencing of RNA isolated by crosslinking immunoprecipitation and microarray(RIP-Chip)techniques. Validation of these targets was done using luciferase reporter assays.
[2]PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VIRmiRNA//VmiReg Interactor1 expression None
Tissue or cell line BC-1 cells//BC-3 cells//BJAB cells Interactor2 expression Downregulation
Description Thirty-six combinations of 3'UTR indicators and KSHV miRNAs with PAR-CLIP interactions were tested for regulation. Nine of these interactions were independently also predicted by microarray analysis of the BJAB cell pools expressing miR-K1, miR-K4-3p, or miR-K11 described above (i.e. for miR-K1: NMI, RAD21, BCL11A, RFXAP; for miR-K4-3p: TPD52, GRB2, MCC, YWHAB; for miR-K11: WEE1). Targets were representative of the full range of seed match types observed in the libraries (Tables S6 and S11).

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