Detail Information

Basic Information:


  VIRBase ID:  

VHID00434586

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-5p:           PCYOX1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-1-5p PCYOX1
miRBase
Accession/Entrez ID		 MIMAT0002182 51449
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - PCL1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PCYOX1
chr2:70506881(+) A-I      3'UTR
chr2:70506750(+) A-I      3'UTR
chr2:70506763(+) A-I      3'UTR
chr2:70506850(+) A-I      3'UTR
chr2:70506787(+) A-I      3'UTR
chr2:70506876(+) A-I      3'UTR
chr2:70506866(+) A-I      3'UTR
chr2:70506844(+) A-I      3'UTR
chr2:70506806(+) A-I      3'UTR
chr2:70506865(+) A-I      3'UTR
chr2:70506744(+) A-I      3'UTR
chr2:70506715(+) A-I      3'UTR
chr2:70506726(+) A-I      3'UTR
chr2:70506749(+) A-I      3'UTR
chr2:70506737(+) A-I      3'UTR
chr2:70506731(+) A-I      3'UTR
chr2:70506823(+) A-I      3'UTR
chr2:70491892(+) A-I      intronic
chr2:70490909(+) A-I      intronic
chr2:70490885(+) A-I      intronic
chr2:70489398(+) A-I      intronic
chr2:70496571(+) A-I      intronic
chr2:70490872(+) A-I      intronic
chr2:70490188(+) A-I      intronic
chr2:70489960(+) A-I      intronic
chr2:70489532(+) A-I      intronic
chr2:70495900(+) A-I      intronic
chr2:70496567(+) A-I      intronic
chr2:70496568(+) A-I      intronic
chr2:70491893(+) A-I      intronic
chr2:70492047(+) A-I      intronic
chr2:70495156(+) A-I      intronic
chr2:70495810(+) A-I      intronic
chr2:70495824(+) A-I      intronic
chr2:70495853(+) A-I      intronic
chr2:70495873(+) A-I      intronic
chr2:70491998(+) A-I      intronic
chr2:70495774(+) A-I      intronic
chr2:70487477(+) A-I      intronic
chr2:70490187(+) A-I      intronic
chr2:70491280(+) A-I      intronic
chr2:70491985(+) A-I      intronic
chr2:70492053(+) A-I      intronic
chr2:70490201(+) A-I      intronic
chr2:70495696(+) A-I      intronic
chr2:70495215(+) A-I      intronic
chr2:70506150(+) A-I      3'UTR
chr2:70506716(+) A-I      3'UTR
chr2:70506796(+) A-I      3'UTR
chr2:70506797(+) A-I      3'UTR
chr2:70506648(+) A-I      3'UTR
chr2:70495847(+) A-I      intronic
chr2:70490165(+) A-I      intronic
chr2:70487473(+) A-I      intronic
chr2:70491986(+) A-I      intronic
chr2:70495912(+) A-I      intronic
chr2:70490245(+) A-I      intronic
chr2:70487540(+) A-I      intronic
chr2:70487405(+) A-I      intronic
chr2:70495082(+) A-I      intronic
chr2:70490170(+) A-I      intronic
chr2:70491742(+) A-I      intronic
chr2:70487529(+) A-I      intronic
chr2:70487596(+) A-I      intronic
chr2:70495910(+) A-I      intronic
chr2:70487476(+) A-I      intronic
chr2:70495126(+) A-I      intronic
chr2:70491984(+) A-I      intronic
chr2:70491679(+) A-I      intronic
chr2:70491995(+) A-I      intronic
chr2:70490921(+) A-I      intronic
chr2:70496669(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PCYOX1
chr2:70502703-70502704(+) m6A CDS//exon       24209618
chr2:70502779-70502780(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr2:70502785-70502786(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22608085
chr2:70503906-70503907(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr2:70503912-70503913(+) m6A CDS//exon//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr2:70503922-70503923(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr2:70504085-70504086(+) m6A CDS//intron       24284625//24209618//24981863//26404942//22608085
chr2:70504209-70504210(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//22608085
chr2:70504239-70504240(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//22608085
chr2:70504474-70504475(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr2:70504505-70504506(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr2:70504512-70504513(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr2:70504517-70504518(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr2:70504581-70504582(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr2:70504608-70504609(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr2:70504667-70504668(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr2:70504768-70504769(+) m6A 3'UTR       24284625
chr2:70504863-70504864(+) m6A 3'UTR       24284625
chr2:70505111-70505112(+) Y 3'UTR       26075521
chr2:70505320-70505321(+) m6A 3'UTR       26404942
chr2:70505372-70505373(+) m6A 3'UTR       26404942
chr2:70505404-70505405(+) m6A 3'UTR       26404942
chr2:70505416-70505417(+) m6A 3'UTR       26404942
chr2:70505633-70505634(+) m6A 3'UTR       26404942
chr2:70505685-70505686(+) m6A 3'UTR       26404942
chr2:70505932-70505933(+) m6A 3'UTR       24981863
chr2:70505943-70505944(+) m6A 3'UTR       24981863
chr2:70505948-70505949(+) m6A 3'UTR       24981863
chr2:70505956-70505957(+) Am 3'UTR       -
chr2:70506027-70506028(+) m6A 3'UTR       24981863
chr2:70506050-70506051(+) m6A 3'UTR       24981863
chr2:70507311-70507312(+) m6A 3'UTR       26404942
chr2:70507333-70507334(+) m6A 3'UTR       26404942
chr2:70507955-70507956(+) Y 3'UTR       25219674
chr2:70508173-70508174(+) m6A 3'UTR       27773535
chr2:70508212-70508213(+) m6A 3'UTR       27773535
chr2:70508302-70508303(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate PCYOX1
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol HCC cell line (HepG2)     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-1-5p
Interactor2: PCYOX1

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence miRanda//Targetscan
Support Database ViRBase//VmiReg

References:


PMID 22174674 Target region None
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line EA.hy926 cells Interactor2 expression Downregulation
Description As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).

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