Basic Information:

  VIRBase ID:  

VHID00433715

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-5p:  MIMAT0002182          ARPC5:  NM_001270439     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-1-5p	ARPC5
miRBase Accession/Entrez ID	MIMAT0002182	10092
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARC16//dJ127C7.3//p16-Arc

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARPC5	chr1:183596201-183596202(-) m6A 3'UTR//exon//intron       26404942 chr1:183596206-183596207(-) m6A 3'UTR//exon//intron       26404942 chr1:183596230-183596231(-) m6A 3'UTR//exon//intron       26404942 chr1:183596607-183596608(-) m6A 3'UTR//exon//intron       24284625//24981863//26404942//27371828//22575960//22608085 chr1:183596613-183596614(-) m6A 3'UTR//exon//intron       24284625//24981863//26404942//27371828//22575960//22608085 chr1:183596674-183596675(-) m6A CDS//exon//intron       24284625//24981863//26404942//27371828//22575960//22608085 chr1:183599692-183599693(-) m6A CDS//exon       26404942 chr1:183599770-183599771(-) m6A CDS//exon       27773536//22575960 chr1:183599823-183599824(-) m6A exon//intron       27773536//22575960 chr1:183599840-183599841(-) m6A exon//intron       27773536 chr1:183599915-183599916(-) m6A exon//intron       - chr1:183599952-183599953(-) m6A exon//intron       27773535 chr1:183599961-183599962(-) m6A exon//intron       27773535 chr1:183600079-183600080(-) m6A exon//intron       27773535 chr1:183600118-183600119(-) m6A exon//intron       27773535 chr1:183602204-183602205(-) m6A exon//intron       24209618//25456834//24981863//27371828//27773536 chr1:183602250-183602251(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536 chr1:183602283-183602284(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536 chr1:183602351-183602352(-) m6A exon//intron       24209618//25456834//24981863//27371828//27773536 chr1:183602401-183602402(-) m6A exon//intron       24209618//25456834//24981863//27371828//27773536 chr1:183602428-183602429(-) m6A exon//intron       25456834//27773536 chr1:183603045-183603046(-) m6A exon//intron       24209618//25456834//24981863 chr1:183603053-183603054(-) m6A exon//intron       24209618//25456834//24981863 chr1:183603087-183603088(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr1:183604666-183604667(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr1:183604711-183604712(-) m1A CDS       26863196//26863410 chr1:183604729-183604730(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:183604783-183604784(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ARPC5	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-1-5p
Interactor2: ARPC5

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//PITA//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.