Basic Information:

  VIRBase ID:  

VHID00433324

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6055

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-5p:  MIMAT0002182          OGT:  NM_181673     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-1-5p	OGT
miRBase Accession/Entrez ID	MIMAT0002182	8473
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HINCUT-1//HRNT1//MRX106//O-GLCNAC//OGT1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OGT	chrX:70784845(+) A-I      intronic chrX:70784848(+) A-I      intronic chrX:70790773(+) A-I      intronic chrX:70769095(+) A-I      intronic chrX:70771961(+) A-I      intronic chrX:70792363(+) A-I      intronic chrX:70791818(+) A-I      intronic chrX:70791786(+) A-I      intronic chrX:70790912(+) A-I      intronic chrX:70790857(+) A-I      intronic chrX:70790851(+) A-I      intronic chrX:70771951(+) A-I      intronic chrX:70771887(+) A-I      intronic chrX:70771965(+) A-I      intronic chrX:70771978(+) A-I      intronic chrX:70769096(+) A-I      intronic chrX:70769375(+) A-I      intronic chrX:70769493(+) A-I      intronic chrX:70771262(+) A-I      intronic chrX:70771320(+) A-I      intronic chrX:70771321(+) A-I      intronic chrX:70771322(+) A-I      intronic chrX:70771323(+) A-I      intronic chrX:70771439(+) A-I      intronic chrX:70790770(+) A-I      intronic chrX:70790675(+) A-I      intronic chrX:70790132(+) A-I      intronic chrX:70789991(+) A-I      intronic chrX:70789952(+) A-I      intronic chrX:70789947(+) A-I      intronic chrX:70789528(+) A-I      intronic chrX:70771993(+) A-I      intronic chrX:70772025(+) A-I      intronic chrX:70772262(+) A-I      intronic chrX:70772368(+) A-I      intronic chrX:70790783(+) A-I      intronic chrX:70772414(+) A-I      intronic chrX:70772496(+) A-I      intronic chrX:70784851(+) A-I      intronic chrX:70771803(+) A-I      intronic chrX:70792566(+) A-I      intronic chrX:70792542(+) A-I      intronic chrX:70784878(+) A-I      intronic chrX:70785095(+) A-I      intronic chrX:70785216(+) A-I      intronic chrX:70785255(+) A-I      intronic chrX:70785313(+) A-I      intronic chrX:70772497(+) A-I      intronic chrX:70779952(+) A-I      intronic chrX:70779964(+) A-I      intronic chrX:70785340(+) A-I      intronic chrX:70785342(+) A-I      intronic chrX:70788567(+) A-I      intronic chrX:70788571(+) A-I      intronic chrX:70788599(+) A-I      intronic chrX:70788610(+) A-I      intronic chrX:70788635(+) A-I      intronic chrX:70788902(+) A-I      intronic chrX:70788924(+) A-I      intronic chrX:70785314(+) A-I      intronic chrX:70785301(+) A-I      intronic chrX:70775357(+) A-I      intronic chrX:70775346(+) A-I      intronic chrX:70769489(+) A-I      intronic chrX:70769486(+) A-I      intronic chrX:70769454(+) A-I      intronic chrX:70769458(+) A-I      intronic chrX:70768953(+) A-I      intronic chrX:70772378(+) A-I      intronic chrX:70772404(+) A-I      intronic chrX:70768930(+) A-I      intronic chrX:70768886(+) A-I      intronic chrX:70792523(+) A-I      intronic chrX:70792466(+) A-I      intronic chrX:70792440(+) A-I      intronic chrX:70792429(+) A-I      intronic chrX:70792377(+) A-I      intronic chrX:70775381(+) A-I      intronic chrX:70779968(+) A-I      intronic chrX:70786948(+) A-I      intronic chrX:70792596(+) A-I      intronic chrX:70786945(+) A-I      intronic chrX:70786943(+) A-I      intronic chrX:70786934(+) A-I      intronic chrX:70786901(+) A-I      intronic chrX:70786899(+) A-I      intronic chrX:70786894(+) A-I      intronic chrX:70786890(+) A-I      intronic chrX:70786827(+) A-I      intronic chrX:70786806(+) A-I      intronic chrX:70785609(+) A-I      intronic chrX:70785606(+) A-I      intronic chrX:70785604(+) A-I      intronic chrX:70775322(+) A-I      intronic chrX:70785600(+) A-I      intronic chrX:70768893(+) A-I      intronic chrX:70768905(+) A-I      intronic chrX:70768955(+) A-I      intronic chrX:70785583(+) A-I      intronic chrX:70768973(+) A-I      intronic chrX:70775310(+) A-I      intronic chrX:70785550(+) A-I      intronic chrX:70785579(+) A-I      intronic chrX:70786942(+) A-I      intronic chrX:70768974(+) A-I      intronic chrX:70768992(+) A-I      intronic chrX:70769092(+) A-I      intronic chrX:70779972(+) A-I      intronic chrX:70780035(+) A-I      intronic chrX:70780073(+) A-I      intronic chrX:70780074(+) A-I      intronic chrX:70780829(+) A-I      intronic chrX:70780839(+) A-I      intronic chrX:70780852(+) A-I      intronic chrX:70780878(+) A-I      intronic chrX:70780958(+) A-I      intronic chrX:70781294(+) A-I      intronic chrX:70781298(+) A-I      intronic chrX:70788925(+) A-I      intronic chrX:70788933(+) A-I      intronic chrX:70789001(+) A-I      intronic chrX:70789012(+) A-I      intronic chrX:70789015(+) A-I      intronic chrX:70789057(+) A-I      intronic chrX:70789063(+) A-I      intronic chrX:70789067(+) A-I      intronic chrX:70784743(+) A-I      intronic chrX:70784751(+) A-I      intronic chrX:70771952(+) A-I      intronic chrX:70785261(+) A-I      intronic chrX:70784847(+) A-I      intronic chrX:70789392(+) A-I      intronic chrX:70784735(+) A-I      intronic chrX:70772503(+) A-I      intronic chrX:70789453(+) A-I      intronic chrX:70784913(+) A-I      intronic chrX:70785341(+) A-I      intronic chrX:70791759(+) A-I      intronic chrX:70785170(+) A-I      intronic chrX:70785347(+) A-I      intronic chrX:70784846(+) A-I      intronic chrX:70789686(+) A-I      intronic chrX:70785276(+) A-I      intronic chrX:70789084(+) A-I      intronic chrX:70788930(+) A-I      intronic chrX:70785194(+) A-I      intronic chrX:70771974(+) A-I      intronic chrX:70779877(+) A-I      intronic chrX:70771882(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	OGT	chrX:70772332(+) A-I intron -    22327324 chrX:70772339(+) A-I intron -    22327324 chrX:70784846(+) A-I intron -    22327324 chrX:70784847(+) A-I intron -    22327324 chrX:70785170(+) A-I intron -    22327324 chrX:70785597(+) A-I intron -    22327324 chrX:70786802(+) A-I intron -    22327324 chrX:70786866(+) A-I intron -    22327324 chrX:70786889(+) A-I intron -    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OGT	chrX:70752961-70752962(+) m6A 5'UTR//exon       24284625//24981863//22608085 chrX:70753109-70753110(+) m6A 5'UTR//exon       24284625//24981863//22575960 chrX:70764501-70764502(+) m6A exon//intron       22608085 chrX:70764511-70764512(+) m6A exon//intron       22608085 chrX:70764528-70764529(+) m6A exon//intron       24981863//22608085 chrX:70764579-70764580(+) m6A exon//intron       24981863//26404942//27773535//22608085 chrX:70764592-70764593(+) m6A exon//intron       24284625//24981863//26404942//27773535//22608085 chrX:70764602-70764603(+) m6A exon//intron       24284625//24981863//26404942//27773535//22608085 chrX:70764681-70764682(+) m6A exon//intron       24284625//24981863//26404942//22575960//22608085 chrX:70764687-70764688(+) m6A exon//intron       24284625//24981863//26404942//22575960//22608085 chrX:70764715-70764716(+) m6A exon//intron       24284625//24981863//26404942//22575960//22608085 chrX:70764829-70764830(+) m6A exon//intron       24284625//24981863//26404942//22608085 chrX:70765029-70765030(+) m6A exon//intron       24284625 chrX:70767261-70767262(+) m6A exon//intron       26404942 chrX:70767290-70767291(+) m6A exon//intron       26404942 chrX:70767331-70767332(+) m6A exon//intron       26404942 chrX:70767345-70767346(+) m6A exon//intron       26404942 chrX:70767362-70767363(+) m6A exon//intron       26404942 chrX:70767401-70767402(+) m6A exon//intron       26404942 chrX:70783200-70783201(+) m6A CDS//exon       27773535 chrX:70783291-70783292(+) m6A CDS//exon       26404942 chrX:70783333-70783334(+) m6A CDS//exon       26404942 chrX:70783346-70783347(+) Cm CDS//exon       - chrX:70787666-70787667(+) m6A exon//intron       - chrX:70787847-70787848(+) m6A CDS//exon       24284625 chrX:70787914-70787915(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chrX:70787932-70787933(+) m6A CDS//exon       24284625//24981863//27773535//22608085 chrX:70787952-70787953(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793532-70793533(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793547-70793548(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793598-70793599(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793650-70793651(+) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chrX:70793705-70793706(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:70793789-70793790(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:70793815-70793816(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:70793831-70793832(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chrX:70793838-70793839(+) Y 3'UTR//exon       26075521 chrX:70794133-70794134(+) m6A 3'UTR//exon       24284625//24981863//22608085 chrX:70794153-70794154(+) m6A 3'UTR//exon       24284625//24981863//22608085 chrX:70794188-70794189(+) m6A 3'UTR//exon       24284625//24981863//22608085 chrX:70794392-70794393(+) Y 3'UTR//exon       26075521 chrX:70794821-70794822(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:70794865-70794866(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:70794899-70794900(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:70794917-70794918(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chrX:70794987-70794988(+) m6A 3'UTR       24284625//26404942 chrX:70795176-70795177(+) m6A 3'UTR       26404942 chrX:70795244-70795245(+) m6A 3'UTR       24284625//26404942 chrX:70795265-70795266(+) m6A 3'UTR       24284625//26404942 chrX:70795380-70795381(+) m6A 3'UTR       24284625//26404942 chrX:70795500-70795501(+) m6A 3'UTR       24284625//26404942 chrX:70795588-70795589(+) m6A 3'UTR       24284625//27773535 chrX:70795624-70795625(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	OGT	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-1-5p
Interactor2: OGT

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.