Basic Information:

  VIRBase ID:  

VHID00432372

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6775

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-5p:  MIMAT0002182          GTF2F2:  NM_004128     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-1-5p	GTF2F2
miRBase Accession/Entrez ID	MIMAT0002182	2963
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BTF4//RAP30//TF2F2//TFIIF

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GTF2F2	chr13:45822247(+) A-I      intronic chr13:45822225(+) A-I      intronic chr13:45822238(+) A-I      intronic chr13:45846808(+) A-I      intronic chr13:45846801(+) A-I      intronic chr13:45846768(+) A-I      intronic chr13:45846800(+) A-I      intronic chr13:45822240(+) A-I      intronic chr13:45846758(+) A-I      intronic chr13:45804089(+) A-I      intronic chr13:45735831(+) A-I      intronic chr13:45737550(+) A-I      intronic chr13:45847032(+) A-I      intronic chr13:45755147(+) A-I      intronic chr13:45836903(+) A-I      intronic chr13:45856688(+) A-I      intronic chr13:45856274(+) A-I      intronic chr13:45856261(+) A-I      intronic chr13:45856148(+) A-I      intronic chr13:45853972(+) A-I      intronic chr13:45848939(+) A-I      intronic chr13:45848925(+) A-I      intronic chr13:45848899(+) A-I      intronic chr13:45848848(+) A-I      intronic chr13:45726324(+) A-I      intronic chr13:45848818(+) A-I      intronic chr13:45848814(+) A-I      intronic chr13:45848703(+) A-I      intronic chr13:45848681(+) A-I      intronic chr13:45845855(+) A-I      intronic chr13:45845816(+) A-I      intronic chr13:45845748(+) A-I      intronic chr13:45845583(+) A-I      intronic chr13:45845558(+) A-I      intronic chr13:45845173(+) A-I      intronic chr13:45848852(+) A-I      intronic chr13:45841209(+) A-I      intronic chr13:45838521(+) A-I      intronic chr13:45838517(+) A-I      intronic chr13:45836466(+) A-I      intronic chr13:45836434(+) A-I      intronic chr13:45836415(+) A-I      intronic chr13:45835155(+) A-I      intronic chr13:45836325(+) A-I      intronic chr13:45835154(+) A-I      intronic chr13:45835114(+) A-I      intronic chr13:45835097(+) A-I      intronic chr13:45824379(+) A-I      intronic chr13:45824364(+) A-I      intronic chr13:45824233(+) A-I      intronic chr13:45821718(+) A-I      intronic chr13:45821714(+) A-I      intronic chr13:45821251(+) A-I      intronic chr13:45804199(+) A-I      intronic chr13:45818923(+) A-I      intronic chr13:45818829(+) A-I      intronic chr13:45702871(+) A-I      intronic chr13:45812299(+) A-I      intronic chr13:45812275(+) A-I      intronic chr13:45812169(+) A-I      intronic chr13:45809866(+) A-I      intronic chr13:45725582(+) A-I      intronic chr13:45809842(+) A-I      intronic chr13:45809825(+) A-I      intronic chr13:45808985(+) A-I      intronic chr13:45806628(+) A-I      intronic chr13:45805445(+) A-I      intronic chr13:45805443(+) A-I      intronic chr13:45805323(+) A-I      intronic chr13:45797127(+) A-I      intronic chr13:45797124(+) A-I      intronic chr13:45791330(+) A-I      intronic chr13:45791273(+) A-I      intronic chr13:45790863(+) A-I      intronic chr13:45790237(+) A-I      intronic chr13:45790131(+) A-I      intronic chr13:45777357(+) A-I      intronic chr13:45777351(+) A-I      intronic chr13:45777312(+) A-I      intronic chr13:45848686(+) A-I      intronic chr13:45777311(+) A-I      intronic chr13:45777292(+) A-I      intronic chr13:45777281(+) A-I      intronic chr13:45776887(+) A-I      intronic chr13:45776863(+) A-I      intronic chr13:45776525(+) A-I      intronic chr13:45776260(+) A-I      intronic chr13:45769991(+) A-I      intronic chr13:45769981(+) A-I      intronic chr13:45769974(+) A-I      intronic chr13:45761292(+) A-I      intronic chr13:45761291(+) A-I      intronic chr13:45761270(+) A-I      intronic chr13:45761263(+) A-I      intronic chr13:45755227(+) A-I      intronic chr13:45755208(+) A-I      intronic chr13:45755042(+) A-I      intronic chr13:45747937(+) A-I      intronic chr13:45747934(+) A-I      intronic chr13:45747919(+) A-I      intronic chr13:45747882(+) A-I      intronic chr13:45747814(+) A-I      intronic chr13:45747804(+) A-I      intronic chr13:45744360(+) A-I      intronic chr13:45744233(+) A-I      intronic chr13:45738800(+) A-I      intronic chr13:45738661(+) A-I      intronic chr13:45738634(+) A-I      intronic chr13:45738592(+) A-I      intronic chr13:45738229(+) A-I      intronic chr13:45776320(+) A-I      intronic chr13:45738138(+) A-I      intronic chr13:45738074(+) A-I      intronic chr13:45738073(+) A-I      intronic chr13:45737596(+) A-I      intronic chr13:45737591(+) A-I      intronic chr13:45737528(+) A-I      intronic chr13:45737524(+) A-I      intronic chr13:45737521(+) A-I      intronic chr13:45846668(+) A-I      intronic chr13:45790675(+) A-I      intronic chr13:45737516(+) A-I      intronic chr13:45737514(+) A-I      intronic chr13:45735919(+) A-I      intronic chr13:45735790(+) A-I      intronic chr13:45733626(+) A-I      intronic chr13:45733590(+) A-I      intronic chr13:45731981(+) A-I      intronic chr13:45731918(+) A-I      intronic chr13:45731820(+) A-I      intronic chr13:45728069(+) A-I      intronic chr13:45727992(+) A-I      intronic chr13:45836662(+) A-I      intronic chr13:45727991(+) A-I      intronic chr13:45727981(+) A-I      intronic chr13:45727436(+) A-I      intronic chr13:45727360(+) A-I      intronic chr13:45726230(+) A-I      intronic chr13:45726180(+) A-I      intronic chr13:45718783(+) A-I      intronic chr13:45718761(+) A-I      intronic chr13:45718758(+) A-I      intronic chr13:45718752(+) A-I      intronic chr13:45718742(+) A-I      intronic chr13:45718627(+) A-I      intronic chr13:45718267(+) A-I      intronic chr13:45718201(+) A-I      intronic chr13:45718200(+) A-I      intronic chr13:45718131(+) A-I      intronic chr13:45718125(+) A-I      intronic chr13:45702990(+) A-I      intronic chr13:45702963(+) A-I      intronic chr13:45702830(+) A-I      intronic chr13:45702663(+) A-I      intronic chr13:45702658(+) A-I      intronic chr13:45846961(+) A-I      intronic chr13:45700592(+) A-I      intronic chr13:45700570(+) A-I      intronic chr13:45845312(+) A-I      intronic chr13:45756339(+) A-I      intronic chr13:45702588(+) A-I      intronic chr13:45728033(+) A-I      intronic chr13:45845567(+) A-I      intronic chr13:45701951(+) A-I      intronic chr13:45744239(+) A-I      intronic chr13:45821052(+) A-I      intronic chr13:45809065(+) A-I      intronic chr13:45761247(+) A-I      intronic chr13:45705850(+) A-I      intronic chr13:45836370(+) A-I      intronic chr13:45846645(+) A-I      intronic chr13:45731847(+) A-I      intronic chr13:45856670(+) A-I      intronic chr13:45776886(+) A-I      intronic chr13:45718138(+) A-I      intronic chr13:45738111(+) A-I      intronic chr13:45738738(+) A-I      intronic chr13:45848881(+) A-I      intronic chr13:45820331(+) A-I      intronic chr13:45838680(+) A-I      intronic chr13:45812228(+) A-I      intronic chr13:45833441(+) A-I      intronic chr13:45738596(+) A-I      intronic chr13:45835810(+) A-I      intronic chr13:45755154(+) A-I      intronic chr13:45728032(+) A-I      intronic chr13:45821792(+) A-I      intronic chr13:45705894(+) A-I      intronic chr13:45809858(+) A-I      intronic chr13:45738798(+) A-I      intronic chr13:45845306(+) A-I      intronic chr13:45759193(+) A-I      intronic chr13:45836388(+) A-I      intronic chr13:45837411(+) A-I      intronic chr13:45845764(+) A-I      intronic chr13:45758039(+) A-I      intronic chr13:45847024(+) A-I      intronic chr13:45755181(+) A-I      intronic chr13:45835312(+) A-I      intronic chr13:45846900(+) A-I      intronic chr13:45705202(+) A-I      intronic chr13:45848957(+) A-I      intronic chr13:45848992(+) A-I      intronic chr13:45839184(+) A-I      intronic chr13:45809001(+) A-I      intronic chr13:45726284(+) A-I      intronic chr13:45738416(+) A-I      intronic chr13:45790732(+) A-I      intronic chr13:45836282(+) A-I      intronic chr13:45726151(+) A-I      intronic chr13:45821383(+) A-I      intronic chr13:45806547(+) A-I      intronic chr13:45846805(+) A-I      intronic chr13:45812311(+) A-I      intronic chr13:45756307(+) A-I      intronic chr13:45846994(+) A-I      intronic chr13:45744352(+) A-I      intronic chr13:45836491(+) A-I      intronic chr13:45806504(+) A-I      intronic chr13:45835016(+) A-I      intronic chr13:45791396(+) A-I      intronic chr13:45812158(+) A-I      intronic chr13:45755212(+) A-I      intronic chr13:45847178(+) A-I      intronic chr13:45846752(+) A-I      intronic chr13:45848845(+) A-I      intronic chr13:45702585(+) A-I      intronic chr13:45756386(+) A-I      intronic chr13:45791372(+) A-I      intronic chr13:45836754(+) A-I      intronic chr13:45819997(+) A-I      intronic chr13:45836293(+) A-I      intronic chr13:45739499(+) A-I      intronic chr13:45756350(+) A-I      intronic chr13:45790721(+) A-I      intronic chr13:45837063(+) A-I      intronic chr13:45756365(+) A-I      intronic chr13:45726233(+) A-I      intronic chr13:45812364(+) A-I      intronic chr13:45756349(+) A-I      intronic chr13:45845320(+) A-I      intronic chr13:45822049(+) A-I      intronic chr13:45856709(+) A-I      intronic chr13:45845240(+) A-I      intronic chr13:45738720(+) A-I      intronic chr13:45835549(+) A-I      intronic chr13:45731901(+) A-I      intronic chr13:45790707(+) A-I      intronic chr13:45733619(+) A-I      intronic chr13:45726107(+) A-I      intronic chr13:45837493(+) A-I      intronic chr13:45848931(+) A-I      intronic chr13:45845264(+) A-I      intronic chr13:45718264(+) A-I      intronic chr13:45848649(+) A-I      intronic chr13:45846644(+) A-I      intronic chr13:45756390(+) A-I      intronic chr13:45808995(+) A-I      intronic chr13:45762102(+) A-I      intronic chr13:45699584(+) A-I      intronic chr13:45845820(+) A-I      intronic chr13:45856769(+) A-I      intronic chr13:45820004(+) A-I      intronic chr13:45836265(+) A-I      intronic chr13:45846764(+) A-I      intronic chr13:45812273(+) A-I      intronic chr13:45821260(+) A-I      intronic chr13:45723512(+) A-I      intronic chr13:45723467(+) A-I      intronic chr13:45848892(+) A-I      intronic chr13:45790770(+) A-I      intronic chr13:45791272(+) A-I      intronic chr13:45834908(+) A-I      intronic chr13:45848671(+) A-I      intronic chr13:45835141(+) A-I      intronic chr13:45821403(+) A-I      intronic chr13:45741911(+) A-I      intronic chr13:45790671(+) A-I      intronic chr13:45755039(+) A-I      intronic chr13:45777345(+) A-I      intronic chr13:45756385(+) A-I      intronic chr13:45848798(+) A-I      intronic chr13:45705208(+) A-I      intronic chr13:45848935(+) A-I      intronic chr13:45791278(+) A-I      intronic chr13:45712968(+) A-I      intronic chr13:45809923(+) A-I      intronic chr13:45705794(+) A-I      intronic chr13:45705888(+) A-I      intronic chr13:45845756(+) A-I      intronic chr13:45820199(+) A-I      intronic chr13:45755251(+) A-I      intronic chr13:45836979(+) A-I      intronic chr13:45777455(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GTF2F2	chr13:45790707(+) A-G intron -    22484847 chr13:45790721(+) A-G intron -    22484847 chr13:45790770(+) A-G intron -    22484847 chr13:45822049(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GTF2F2	chr13:45827029-45827030(+) m6A CDS//exon       24981863 chr13:45827055-45827056(+) m6A CDS//exon       24981863//27773535 chr13:45827080-45827081(+) m6A CDS//exon       24981863//27773535 chr13:45841420-45841421(+) m6A CDS//exon       24981863//27773535 chr13:45841434-45841435(+) m6A CDS//exon       24981863//27773535 chr13:45841459-45841460(+) m6A CDS//exon       24981863//27773535 chr13:45841482-45841483(+) m6A CDS//exon       24981863//27773535 chr13:45841491-45841492(+) m6A CDS//exon       24981863//27773535 chr13:45857637-45857638(+) m6A CDS       24981863//27773535 chr13:45857665-45857666(+) m6A CDS       24981863//27773535 chr13:45857700-45857701(+) m6A 3'UTR       24981863//27773535 chr13:45857773-45857774(+) m6A 3'UTR       24981863 chr13:45857914-45857915(+) m6A 3'UTR       27773535 chr13:45858015-45858016(+) m6A 3'UTR       27773535 chr13:45858087-45858088(+) m6A 3'UTR       27773535 chr13:45858103-45858104(+) m6A 3'UTR       27773535 chr13:45858122-45858123(+) m6A 3'UTR       27773535 chr13:45858155-45858156(+) m6A 3'UTR       27773535 chr13:45858178-45858179(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GTF2F2	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-1-5p
Interactor2: GTF2F2

Evidence Support:

Weak-Evidence	Microarray//PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

[1]PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-3 cells//BJAB cells	Interactor2 expression	Downregulation
Description	Table S10D Genes that contribute to the enrichments of PAR-CLIP targets of miR-K1 from BC-3 libraries in downregulated mRNAs in BJAB/miR-K1 cells.

[2]PMID	22174674	Target region	None
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).