Detail Information

Basic Information:


  VIRBase ID:  

VHID00432014

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-5p:           CAV1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-1-5p CAV1
miRBase
Accession/Entrez ID		 MIMAT0002182 857
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - BSCL3//CGL3//LCCNS//MSTP085//PPH3//VIP21

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CAV1
chr7:116173162(+) A-I      intronic
chr7:116173173(+) A-I      intronic
chr7:116173236(+) A-I      intronic
chr7:116173260(+) A-I      intronic
chr7:116173607(+) A-I      intronic
chr7:116173600(+) A-I      intronic
chr7:116174639(+) A-I      intronic
chr7:116174661(+) A-I      intronic
chr7:116173247(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CAV1
chr7:116173289(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CAV1
chr7:116164900-116164901(+) m6A 5'UTR       24981863
chr7:116164919-116164920(+) m6A 5'UTR       24981863
chr7:116164957-116164958(+) m6A 5'UTR       24981863
chr7:116164961-116164962(+) m6A 5'UTR       24981863
chr7:116165081-116165082(+) m6A 5'UTR//exon       24981863//26404942
chr7:116165138-116165139(+) m6A 5'UTR//CDS//exon       24981863//26404942
chr7:116165554-116165555(+) m6A 3'UTR//5'UTR//intron       24981863
chr7:116165566-116165567(+) m6A 3'UTR//5'UTR//intron       24981863
chr7:116165586-116165587(+) m6A 3'UTR//5'UTR//intron       24981863
chr7:116165641-116165642(+) m6A 3'UTR//5'UTR//intron       24981863
chr7:116165653-116165654(+) m6A 3'UTR//5'UTR//intron       24981863
chr7:116165701-116165702(+) m6A 3'UTR//5'UTR//intron       24981863
chr7:116165716-116165717(+) m6A 3'UTR//5'UTR//intron       24981863
chr7:116166580-116166581(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24981863//26404942//22575960
chr7:116166607-116166608(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24981863//26404942
chr7:116166718-116166719(+) m6A 3'UTR//CDS//exon       24981863//26404942
chr7:116166776-116166777(+) m6A exon//intron       26404942
chr7:116199025-116199026(+) m6A 3'UTR//CDS       24284625//24981863//26404942
chr7:116199035-116199036(+) m6A 3'UTR//CDS       24284625//24981863//26404942
chr7:116199547-116199548(+) m6A 3'UTR       24284625//24209618//24981863//26404942
chr7:116199620-116199621(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22608085
chr7:116199658-116199659(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr7:116199689-116199690(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr7:116199797-116199798(+) m6A 3'UTR       24284625//24209618//26404942
chr7:116199885-116199886(+) m6A 3'UTR       26404942
chr7:116199989-116199990(+) m6A 3'UTR       26404942
chr7:116200230-116200231(+) m6A 3'UTR       26404942
chr7:116200365-116200366(+) m6A 3'UTR       24284625//26404942
chr7:116200489-116200490(+) m6A 3'UTR       24284625//24981863//26404942//22575960
chr7:116200570-116200571(+) m6A 3'UTR       24284625//24981863//26404942//22575960
chr7:116200669-116200670(+) m6A 3'UTR       24284625//24981863//26404942
chr7:116200675-116200676(+) m6A 3'UTR       24284625//24981863//26404942
chr7:116200696-116200697(+) m6A 3'UTR       24284625//24981863//26404942
chr7:116200777-116200778(+) m6A 3'UTR       24284625//24981863//26404942
chr7:116200788-116200789(+) m6A 3'UTR       24284625//24981863//26404942
chr7:116200826-116200827(+) m6A 3'UTR       24981863//26404942
chr7:116200909-116200910(+) m6A 3'UTR       24981863//26404942
chr7:116200943-116200944(+) m6A 3'UTR       24981863//26404942
chr7:116201056-116201057(+) m6A 3'UTR       26404942
chr7:116201071-116201072(+) m6A 3'UTR       26404942

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate CAV1
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-1-5p
Interactor2: CAV1

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence miRanda//Targetscan
Support Database ViRBase//VmiReg

References:


PMID 22174674 Target region None
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line EA.hy926 cells Interactor2 expression Downregulation
Description As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).

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