Detail Information

Basic Information:


  VIRBase ID:  

VHID00431924

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9603

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-1-5p:           ANXA2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-1-5p ANXA2
miRBase
Accession/Entrez ID		 MIMAT0002182 302
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - ANX2//ANX2L4//CAL1H//HEL-S-270//LIP2//LPC2//LPC2D//P36//PAP-IV

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ANXA2
chr15:60667234(-) A-I      intronic
chr15:60667228(-) A-I      intronic
chr15:60667226(-) A-I      intronic
chr15:60667208(-) A-I      intronic
chr15:60667206(-) A-I      intronic
chr15:60667188(-) A-I      intronic
chr15:60667187(-) A-I      intronic
chr15:60667184(-) A-I      intronic
chr15:60667169(-) A-I      intronic
chr15:60667230(-) A-I      intronic
chr15:60680885(-) A-I      intronic
chr15:60680304(-) A-I      intronic
chr15:60680287(-) A-I      intronic
chr15:60680265(-) A-I      intronic
chr15:60664248(-) A-I      intronic
chr15:60668768(-) A-I      intronic
chr15:60668770(-) A-I      intronic
chr15:60668784(-) A-I      intronic
chr15:60668826(-) A-I      intronic
chr15:60668892(-) A-I      intronic
chr15:60668896(-) A-I      intronic
chr15:60668911(-) A-I      intronic
chr15:60667232(-) A-I      intronic
chr15:60667270(-) A-I      intronic
chr15:60668812(-) A-I      intronic
chr15:60668762(-) A-I      intronic
chr15:60667261(-) A-I      intronic
chr15:60667259(-) A-I      intronic
chr15:60667243(-) A-I      intronic
chr15:60667237(-) A-I      intronic
chr15:60664236(-) A-I      intronic
chr15:60664272(-) A-I      intronic
chr15:60664309(-) A-I      intronic
chr15:60664265(-) A-I      intronic
chr15:60681095(-) A-I      intronic
chr15:60681087(-) A-I      intronic
chr15:60677524(-) A-I      intronic
chr15:60677510(-) A-I      intronic
chr15:60686860(-) A-I      intronic
chr15:60665004(-) A-I      intronic
chr15:60665094(-) A-I      intronic
chr15:60664971(-) A-I      intronic
chr15:60664953(-) A-I      intronic
chr15:60665074(-) A-I      intronic
chr15:60670175(-) A-I      intronic
chr15:60675394(-) A-I      5'UTR
chr15:60675609(-) A-I      5'UTR
chr15:60675450(-) A-I      5'UTR
chr15:60675428(-) A-I      5'UTR
chr15:60665008(-) A-I      intronic
chr15:60664254(-) A-I      intronic
chr15:60681073(-) A-I      intronic
chr15:60680275(-) A-I      intronic
chr15:60680805(-) A-I      intronic
chr15:60681079(-) A-I      intronic
chr15:60677582(-) A-I      intronic
chr15:60665058(-) A-I      intronic
chr15:60664985(-) A-I      intronic
chr15:60668761(-) A-I      intronic
chr15:60677585(-) A-I      intronic
chr15:60665001(-) A-I      intronic
chr15:60668894(-) A-I      intronic
chr15:60665017(-) A-I      intronic
chr15:60675579(-) A-I      5'UTR
chr15:60675505(-) A-I      5'UTR
chr15:60675464(-) A-I      5'UTR
chr15:60675508(-) A-I      5'UTR
chr15:60675463(-) A-I      5'UTR
chr15:60675386(-) A-I      5'UTR
chr15:60675340(-) A-I      5'UTR
chr15:60675507(-) A-I      5'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ANXA2
chr15:60675505(-) A-I intron -    15258596
chr15:60675507(-) A-I intron -    15258596
chr15:60675508(-) A-I intron -    15258596
chr15:60665004(-) A-I intron -    21960545
chr15:60665094(-) A-I intron -    21960545
chr15:60680275(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ANXA2
chr15:60639430-60639431(-) m6A 3'UTR       27773535
chr15:60639530-60639531(-) m6A 3'UTR       27773535
chr15:60639550-60639551(-) m6A 3'UTR//exon       27773535
chr15:60639562-60639563(-) m6A 3'UTR//exon       27773535
chr15:60639762-60639763(-) m6A 3'UTR//exon       26404942
chr15:60639883-60639884(-) m6A 3'UTR//CDS//exon       26404942
chr15:60641337-60641338(-) m6A 3'UTR//CDS//exon//intron       26404942//22575960
chr15:60643434-60643435(-) m6A 3'UTR//CDS//exon       26404942//22575960
chr15:60643492-60643493(-) m6A exon//intron       22575960
chr15:60643948-60643949(-) m6A 3'UTR//CDS//exon       26404942
chr15:60644641-60644642(-) m6A 3'UTR//CDS//exon       22575960
chr15:60646373-60646374(-) m6A 3'UTR//CDS//exon       22575960
chr15:60653183-60653184(-) m6A 3'UTR//5'UTR//CDS//exon       26404942
chr15:60653250-60653251(-) m6A 3'UTR//5'UTR//CDS//exon       26404942
chr15:60675161-60675162(-) m6A exon//intron       27773535
chr15:60675191-60675192(-) m6A exon//intron       27773535
chr15:60675352-60675353(-) m6A exon//intron       27773535
chr15:60685266-60685267(-) m6A CDS//intron       24209618
chr15:60685274-60685275(-) m6A CDS//intron       24209618
chr15:60685388-60685389(-) m6A 5'UTR//intron       24209618

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ANXA2
Axon SH-5YSY cells     28258160
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HeLa-S3 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-1-5p
Interactor2: ANXA2

Evidence Support:


Strong-Evidence Luciferase reporter assay//Western blot
Weak-Evidence HITS-CLIP//PAR-CLIP
Prediction-Evidence miRanda//Targetscan
Support Database VmiReg

References:


PMID 22927820 Target region None
Source VmiReg Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description All eight 3'UTRs responded to miRNA expression with a dose-dependent decrease of luciferase expression by at least 20%. These included ANXA2, C/EBPa, HLA-C, high mobility group AT-hook 1 (HMGA1), interferon regulatory factor 2 binding protein 2 (IRF2B12), TP53INP1, TPD52, and YWHAE.

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