Basic Information:

  VIRBase ID:  

VHID00431508

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-3p:  MIMAT0002181          FAM241B:  NM_145306     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-11-3p	FAM241B
miRBase Accession/Entrez ID	MIMAT0002181	219738
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	C10orf35

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	FAM241B	chr10:71392164(+) A-I      intronic chr10:71392202(+) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	FAM241B	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-11-3p
Interactor2: FAM241B

Evidence Support:

Weak-Evidence	Microarray
Prediction-Evidence	PicTar//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	18075594	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BJAB cells	Interactor2 expression	Downregulation
Description	Cytoplasmic RNA was isolated from BJAB cells and analyzed on microarrays in three independent experiments. Expression of miR-K12-11 resulted in the downregulation of 181 mRNAs and the upregulation of 86 mRNAs (|T-score| ≥2.86, p≤0.01).Downregulated mRNAs carrying a >6 nt seed match to miR-K12-11 were considered candidate direct targets and are listed in Suppl. Table 1.