Basic Information:

  VIRBase ID:  

VHID00431201

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-3p:  MIMAT0002181          OSBPL11:  NM_022776     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-11-3p	OSBPL11
miRBase Accession/Entrez ID	MIMAT0002181	114885
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ORP-11//ORP11//OSBP12//TCCCIA00292

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	OSBPL11	chr3:125268562(-) A-I      intronic chr3:125268544(-) A-I      intronic chr3:125268534(-) A-I      intronic chr3:125268529(-) A-I      intronic chr3:125300168(-) A-I      intronic chr3:125300149(-) A-I      intronic chr3:125300140(-) A-I      intronic chr3:125300139(-) A-I      intronic chr3:125300132(-) A-I      intronic chr3:125300131(-) A-I      intronic chr3:125300129(-) A-I      intronic chr3:125266814(-) A-I      intronic chr3:125269921(-) A-I      intronic chr3:125300163(-) A-I      intronic chr3:125269053(-) A-I      intronic chr3:125269051(-) A-I      intronic chr3:125268495(-) A-I      intronic chr3:125300114(-) A-I      intronic chr3:125268575(-) A-I      intronic chr3:125266832(-) A-I      intronic chr3:125266865(-) A-I      intronic chr3:125300115(-) A-I      intronic chr3:125269925(-) A-I      intronic chr3:125276864(-) A-I      intronic chr3:125276846(-) A-I      intronic chr3:125276833(-) A-I      intronic chr3:125269926(-) A-I      intronic chr3:125266899(-) A-I      intronic chr3:125268454(-) A-I      intronic chr3:125268463(-) A-I      intronic chr3:125308139(-) A-I      intronic chr3:125308126(-) A-I      intronic chr3:125287218(-) A-I      intronic chr3:125306979(-) A-I      intronic chr3:125306922(-) A-I      intronic chr3:125306854(-) A-I      intronic chr3:125304878(-) A-I      intronic chr3:125304153(-) A-I      intronic chr3:125304142(-) A-I      intronic chr3:125302505(-) A-I      intronic chr3:125302411(-) A-I      intronic chr3:125302373(-) A-I      intronic chr3:125302316(-) A-I      intronic chr3:125300651(-) A-I      intronic chr3:125296565(-) A-I      intronic chr3:125296561(-) A-I      intronic chr3:125296557(-) A-I      intronic chr3:125295698(-) A-I      intronic chr3:125295692(-) A-I      intronic chr3:125292640(-) A-I      intronic chr3:125292633(-) A-I      intronic chr3:125278419(-) A-I      intronic chr3:125287082(-) A-I      intronic chr3:125286710(-) A-I      intronic chr3:125285702(-) A-I      intronic chr3:125285701(-) A-I      intronic chr3:125285676(-) A-I      intronic chr3:125284970(-) A-I      intronic chr3:125283973(-) A-I      intronic chr3:125283970(-) A-I      intronic chr3:125283967(-) A-I      intronic chr3:125283631(-) A-I      intronic chr3:125278938(-) A-I      intronic chr3:125278618(-) A-I      intronic chr3:125278420(-) A-I      intronic chr3:125268513(-) A-I      intronic chr3:125278408(-) A-I      intronic chr3:125278403(-) A-I      intronic chr3:125278353(-) A-I      intronic chr3:125276726(-) A-I      intronic chr3:125270575(-) A-I      intronic chr3:125270546(-) A-I      intronic chr3:125269964(-) A-I      intronic chr3:125269956(-) A-I      intronic chr3:125269865(-) A-I      intronic chr3:125269838(-) A-I      intronic chr3:125269836(-) A-I      intronic chr3:125269049(-) A-I      intronic chr3:125269001(-) A-I      intronic chr3:125268569(-) A-I      intronic chr3:125268563(-) A-I      intronic chr3:125268532(-) A-I      intronic chr3:125254507(-) A-I      intronic chr3:125268509(-) A-I      intronic chr3:125268061(-) A-I      intronic chr3:125268041(-) A-I      intronic chr3:125268004(-) A-I      intronic chr3:125267998(-) A-I      intronic chr3:125267981(-) A-I      intronic chr3:125267977(-) A-I      intronic chr3:125266996(-) A-I      intronic chr3:125265187(-) A-I      intronic chr3:125262730(-) A-I      intronic chr3:125262692(-) A-I      intronic chr3:125262553(-) A-I      intronic chr3:125261756(-) A-I      intronic chr3:125261317(-) A-I      intronic chr3:125261308(-) A-I      intronic chr3:125255935(-) A-I      intronic chr3:125255928(-) A-I      intronic chr3:125255921(-) A-I      intronic chr3:125255823(-) A-I      intronic chr3:125255811(-) A-I      intronic chr3:125254896(-) A-I      intronic chr3:125254871(-) A-I      intronic chr3:125254867(-) A-I      intronic chr3:125311065(-) A-I      intronic chr3:125311059(-) A-I      intronic chr3:125308155(-) A-I      intronic chr3:125254546(-) A-I      intronic chr3:125252296(-) A-I      intronic chr3:125252273(-) A-I      intronic chr3:125252272(-) A-I      intronic chr3:125308147(-) A-I      intronic chr3:125300208(-) A-I      intronic chr3:125305404(-) A-I      intronic chr3:125305568(-) A-I      intronic chr3:125305623(-) A-I      intronic chr3:125305614(-) A-I      intronic chr3:125254760(-) A-I      intronic chr3:125304212(-) A-I      intronic chr3:125305565(-) A-I      intronic chr3:125265572(-) A-I      intronic chr3:125254897(-) A-I      intronic chr3:125300737(-) A-I      intronic chr3:125278405(-) A-I      intronic chr3:125279737(-) A-I      intronic chr3:125295724(-) A-I      intronic chr3:125252154(-) A-I      intronic chr3:125269097(-) A-I      intronic chr3:125305634(-) A-I      intronic chr3:125303897(-) A-I      intronic chr3:125304017(-) A-I      intronic chr3:125265408(-) A-I      intronic chr3:125305478(-) A-I      intronic chr3:125267944(-) A-I      intronic chr3:125304255(-) A-I      intronic chr3:125289118(-) A-I      intronic chr3:125295710(-) A-I      intronic chr3:125295800(-) A-I      intronic chr3:125305386(-) A-I      intronic chr3:125305453(-) A-I      intronic chr3:125266858(-) A-I      intronic chr3:125300124(-) A-I      intronic chr3:125254594(-) A-I      intronic chr3:125270383(-) A-I      intronic chr3:125252233(-) A-I      intronic chr3:125269013(-) A-I      intronic chr3:125300650(-) A-I      intronic chr3:125262968(-) A-I      intronic chr3:125309285(-) A-I      intronic chr3:125294653(-) A-I      intronic chr3:125306900(-) A-I      intronic chr3:125304898(-) A-I      intronic chr3:125266950(-) A-I      intronic chr3:125266885(-) A-I      intronic chr3:125262985(-) A-I      intronic chr3:125262755(-) A-I      intronic chr3:125305605(-) A-I      intronic chr3:125269124(-) A-I      intronic chr3:125265384(-) A-I      intronic chr3:125283637(-) A-I      intronic chr3:125258382(-) A-I      intronic chr3:125269186(-) A-I      intronic chr3:125265371(-) A-I      intronic chr3:125286571(-) A-I      intronic chr3:125305559(-) A-I      intronic chr3:125268095(-) A-I      intronic chr3:125305631(-) A-I      intronic chr3:125262622(-) A-I      intronic chr3:125305468(-) A-I      intronic chr3:125261382(-) A-I      intronic chr3:125266859(-) A-I      intronic chr3:125254462(-) A-I      intronic chr3:125278524(-) A-I      intronic chr3:125265149(-) A-I      intronic chr3:125281751(-) A-I      intronic chr3:125269107(-) A-I      intronic chr3:125263181(-) A-I      intronic chr3:125300042(-) A-I      intronic chr3:125310680(-) A-I      intronic chr3:125268558(-) A-I      intronic chr3:125305459(-) A-I      intronic chr3:125300708(-) A-I      intronic chr3:125300074(-) A-I      intronic chr3:125300203(-) A-I      intronic chr3:125300283(-) A-I      intronic chr3:125307022(-) A-I      intronic chr3:125304259(-) A-I      intronic chr3:125306821(-) A-I      intronic chr3:125270460(-) A-I      intronic chr3:125279792(-) A-I      intronic chr3:125262120(-) A-I      intronic chr3:125262072(-) A-I      intronic chr3:125304042(-) A-I      intronic chr3:125252842(-) A-I      intronic chr3:125265612(-) A-I      intronic chr3:125254384(-) A-I      intronic chr3:125303768(-) A-I      intronic chr3:125270449(-) A-I      intronic chr3:125286591(-) A-I      intronic chr3:125269025(-) A-I      intronic chr3:125269052(-) A-I      intronic chr3:125261320(-) A-I      intronic chr3:125283681(-) A-I      intronic chr3:125287150(-) A-I      intronic chr3:125252192(-) A-I      intronic chr3:125258450(-) A-I      intronic chr3:125252189(-) A-I      intronic chr3:125269187(-) A-I      intronic chr3:125284026(-) A-I      intronic chr3:125266853(-) A-I      intronic chr3:125287153(-) A-I      intronic chr3:125268490(-) A-I      intronic chr3:125250274(-) A-I      intronic chr3:125267962(-) A-I      intronic chr3:125302531(-) A-I      intronic chr3:125263137(-) A-I      intronic chr3:125252242(-) A-I      intronic chr3:125255837(-) A-I      intronic chr3:125254426(-) A-I      intronic chr3:125268574(-) A-I      intronic chr3:125286619(-) A-I      intronic chr3:125278402(-) A-I      intronic chr3:125300625(-) A-I      intronic chr3:125268530(-) A-I      intronic chr3:125254377(-) A-I      intronic chr3:125268466(-) A-I      intronic chr3:125252809(-) A-I      intronic chr3:125305373(-) A-I      intronic chr3:125255846(-) A-I      intronic chr3:125268983(-) A-I      intronic chr3:125307052(-) A-I      intronic chr3:125268020(-) A-I      intronic chr3:125255856(-) A-I      intronic chr3:125266900(-) A-I      intronic chr3:125305425(-) A-I      intronic chr3:125309202(-) A-I      intronic chr3:125303883(-) A-I      intronic chr3:125268140(-) A-I      intronic chr3:125306883(-) A-I      intronic chr3:125265578(-) A-I      intronic chr3:125276775(-) A-I      intronic chr3:125252844(-) A-I      intronic chr3:125300092(-) A-I      intronic chr3:125302965(-) A-I      intronic chr3:125263038(-) A-I      intronic chr3:125300645(-) A-I      intronic chr3:125300100(-) A-I      intronic chr3:125268017(-) A-I      intronic chr3:125278401(-) A-I      intronic chr3:125279736(-) A-I      intronic chr3:125252225(-) A-I      intronic chr3:125287927(-) A-I      intronic chr3:125310813(-) A-I      intronic chr3:125269143(-) A-I      intronic chr3:125259087(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	OSBPL11	chr3:125263093(-) A-I intron -    15258596 chr3:125263137(-) A-I intron -    15258596 chr3:125263181(-) A-I intron -    15258596 chr3:125263186(-) A-I intron -    15258596 chr3:125305386(-) A-I intron -    22028664 chr3:125305404(-) A-I intron -    22028664 chr3:125305433(-) A-I intron -    22028664 chr3:125305453(-) A-I intron -    22028664 chr3:125305459(-) A-I intron -    22028664 chr3:125305468(-) A-I intron -    22028664 chr3:125305478(-) A-I intron -    22028664 chr3:125305559(-) A-I intron -    22028664 chr3:125305565(-) A-I intron -    22028664 chr3:125305568(-) A-I intron -    22028664 chr3:125305605(-) A-I intron -    22028664 chr3:125305614(-) A-I intron -    22028664 chr3:125305623(-) A-I intron -    22028664 chr3:125305631(-) A-I intron -    22028664 chr3:125305632(-) A-I intron -    22028664 chr3:125254897(-) A-G intron -    22484847 chr3:125262622(-) A-G intron -    22484847 chr3:125262755(-) A-G intron -    22484847 chr3:125266853(-) A-G intron -    22484847 chr3:125266881(-) A-G intron -    22484847 chr3:125268017(-) A-G intron -    22484847 chr3:125268020(-) A-G intron -    22484847 chr3:125268490(-) A-G intron -    22484847 chr3:125268558(-) A-G intron -    22484847 chr3:125268574(-) A-G intron -    22484847 chr3:125268983(-) A-G intron -    22484847 chr3:125269014(-) A-G intron -    22484847 chr3:125269046(-) A-G intron -    22484847 chr3:125269095(-) A-G intron -    22484847 chr3:125269124(-) A-G intron -    22484847 chr3:125269143(-) A-G intron -    22484847 chr3:125269186(-) A-G intron -    22484847 chr3:125269187(-) A-G intron -    22484847 chr3:125283637(-) A-G intron -    22484847 chr3:125283681(-) A-G intron -    22484847 chr3:125287150(-) A-G intron -    22484847 chr3:125287153(-) A-G intron -    22484847 chr3:125295710(-) A-G intron -    22484847 chr3:125303883(-) A-G intron -    22484847 chr3:125304017(-) A-G intron -    22484847 chr3:125304212(-) A-G intron -    22484847 chr3:125304255(-) A-G intron -    22484847 chr3:125304259(-) A-G intron -    22484847 chr3:125305459(-) A-G intron -    22484847 chr3:125305632(-) A-G intron -    22484847 chr3:125305634(-) A-G intron -    22484847 chr3:125306883(-) A-G intron -    22484847 chr3:125306900(-) A-G intron -    22484847 chr3:125306983(-) A-G intron -    22484847 chr3:125307022(-) A-G intron -    22484847 chr3:125309202(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	OSBPL11	chr3:125248493-125248494(-) m6A 3'UTR       27773535 chr3:125248533-125248534(-) m6A 3'UTR       27773535 chr3:125248589-125248590(-) m6A 3'UTR       24981863//27773535 chr3:125248632-125248633(-) m6A 3'UTR       24981863//27773535//22608085 chr3:125248658-125248659(-) m6A 3'UTR       24981863//27773535//22608085 chr3:125248745-125248746(-) m6A 3'UTR       24981863//27773535//22608085 chr3:125248772-125248773(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr3:125248794-125248795(-) m6A 3'UTR       24284625//24981863//27773535//22608085 chr3:125248915-125248916(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr3:125249016-125249017(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr3:125249125-125249126(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr3:125249171-125249172(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:125249180-125249181(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:125249197-125249198(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:125249238-125249239(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:125249247-125249248(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:125249253-125249254(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:125249342-125249343(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr3:125249400-125249401(-) m6A CDS       24284625//24209618//24981863//27773535//22608085 chr3:125250724-125250725(-) m6A CDS       24209618//24981863//27773535//22608085 chr3:125250742-125250743(-) m6A CDS       24209618//24981863//27773535//22608085 chr3:125250766-125250767(-) m6A CDS       24981863//27773535 chr3:125250834-125250835(-) m6A CDS       24981863//27773535 chr3:125257326-125257327(-) m6A CDS       24981863//27773535 chr3:125257363-125257364(-) m6A CDS       24981863 chr3:125257376-125257377(-) m6A CDS       24981863 chr3:125271312-125271313(-) m6A CDS       24981863//22608085 chr3:125271337-125271338(-) m6A CDS       24981863//22608085 chr3:125271410-125271411(-) m6A CDS       24981863//22608085 chr3:125271449-125271450(-) m6A CDS       24981863//22608085 chr3:125271467-125271468(-) m6A CDS       24981863//22608085 chr3:125295054-125295055(-) m6A CDS       27773535 chr3:125295070-125295071(-) m6A CDS       27773535 chr3:125295092-125295093(-) m6A CDS       27773535 chr3:125295101-125295102(-) m6A CDS       27773535 chr3:125295137-125295138(-) m6A CDS       27773535 chr3:125313552-125313553(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//22608085 chr3:125313558-125313559(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//22608085 chr3:125313629-125313630(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr3:125313657-125313658(-) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr3:125313697-125313698(-) m6A 5'UTR       24284625//24209618//24981863//27773535//27371828//22608085 chr3:125313788-125313789(-) m6A 5'UTR       24284625//24981863//27773535//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	OSBPL11	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-11-3p
Interactor2: OSBPL11

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).