Basic Information:

  VIRBase ID:  

VHID00431164

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-3p:  MIMAT0002181          TADA2B:  NM_152293     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-11-3p	TADA2B
miRBase Accession/Entrez ID	MIMAT0002181	93624
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ADA2(beta)//ADA2B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TADA2B	chr4:7059403(+) A-I      3'UTR chr4:7059435(+) A-I      3'UTR chr4:7059338(+) A-I      3'UTR chr4:7059282(+) A-I      3'UTR chr4:7059305(+) A-I      3'UTR chr4:7059307(+) A-I      3'UTR chr4:7059328(+) A-I      3'UTR chr4:7059349(+) A-I      3'UTR chr4:7059361(+) A-I      3'UTR chr4:7059244(+) A-I      3'UTR chr4:7059393(+) A-I      3'UTR chr4:7059399(+) A-I      3'UTR chr4:7059501(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TADA2B	chr4:7059282(+) A-G intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TADA2B	chr4:7045324-7045325(+) m1A CDS//intron       26863196//26863410 chr4:7045388-7045389(+) m6A CDS//intron       24284625 chr4:7045516-7045517(+) m6A CDS//intron       24284625//22608085 chr4:7045571-7045572(+) m6A CDS//intron       24284625//24981863 chr4:7055734-7055735(+) m6A 5'UTR//intron       - chr4:7055761-7055762(+) m6A 5'UTR//intron       24284625 chr4:7055821-7055822(+) m6A CDS       24284625//24981863//22608085 chr4:7055870-7055871(+) m6A CDS       24284625//24981863//22608085 chr4:7055918-7055919(+) m6A CDS       24284625//24981863//22608085 chr4:7055981-7055982(+) m6A CDS       24284625//24981863//22575960//22608085 chr4:7056137-7056138(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7056165-7056166(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7056179-7056180(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7056224-7056225(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr4:7056347-7056348(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr4:7056387-7056388(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr4:7056479-7056480(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr4:7056485-7056486(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22608085 chr4:7056524-7056525(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7056548-7056549(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7056605-7056606(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr4:7056637-7056638(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr4:7056653-7056654(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr4:7056710-7056711(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr4:7056816-7056817(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7056880-7056881(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22608085 chr4:7057142-7057143(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085 chr4:7057294-7057295(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr4:7057336-7057337(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr4:7057361-7057362(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr4:7057381-7057382(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7057443-7057444(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7057585-7057586(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7057595-7057596(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7057673-7057674(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr4:7057837-7057838(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr4:7057952-7057953(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr4:7058039-7058040(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr4:7058089-7058090(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr4:7058123-7058124(+) m6A 3'UTR       24284625//24209618//24981863//22608085 chr4:7058185-7058186(+) m6A 3'UTR       24284625//24981863//22608085 chr4:7058252-7058253(+) m6A 3'UTR       24981863//22608085 chr4:7058350-7058351(+) m6A 3'UTR       24981863//22608085 chr4:7058386-7058387(+) m6A 3'UTR       24981863//22608085 chr4:7058433-7058434(+) m6A 3'UTR       24981863//22608085 chr4:7058544-7058545(+) m6A 3'UTR       24284625//24981863//22608085 chr4:7058753-7058754(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TADA2B	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-11-3p
Interactor2: TADA2B

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).