Basic Information:

  VIRBase ID:  

VHID00430944

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-3p:  MIMAT0002181          TSPAN14:  NM_030927     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-11-3p	TSPAN14
miRBase Accession/Entrez ID	MIMAT0002181	81619
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	DC-TM4F2//TM4SF14//tspan-14

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TSPAN14	chr10:82235171(+) A-I      intronic chr10:82235170(+) A-I      intronic chr10:82243488(+) A-I      intronic chr10:82217086(+) A-I      intronic chr10:82217084(+) A-I      intronic chr10:82243838(+) A-I      intronic chr10:82217074(+) A-I      intronic chr10:82243850(+) A-I      intronic chr10:82215570(+) A-I      intronic chr10:82216663(+) A-I      intronic chr10:82243858(+) A-I      intronic chr10:82243951(+) A-I      intronic chr10:82235138(+) A-I      intronic chr10:82243445(+) A-I      intronic chr10:82226252(+) A-I      5'UTR chr10:82235175(+) A-I      intronic chr10:82243925(+) A-I      intronic chr10:82281995(+) A-I      3'UTR chr10:82243836(+) A-I      intronic chr10:82243508(+) A-I      intronic chr10:82235162(+) A-I      intronic chr10:82282223(+) A-I      3'UTR chr10:82282249(+) A-I      3'UTR chr10:82282120(+) A-I      3'UTR chr10:82282111(+) A-I      3'UTR chr10:82282095(+) A-I      3'UTR chr10:82282071(+) A-I      3'UTR chr10:82282057(+) A-I      3'UTR chr10:82282034(+) A-I      3'UTR chr10:82282017(+) A-I      3'UTR chr10:82242324(+) A-I      intronic chr10:82244188(+) A-I      intronic chr10:82242179(+) A-I      intronic chr10:82243839(+) A-I      intronic chr10:82242172(+) A-I      intronic chr10:82243581(+) A-I      intronic chr10:82243843(+) A-I      intronic chr10:82242136(+) A-I      intronic chr10:82238528(+) A-I      intronic chr10:82243559(+) A-I      intronic chr10:82243450(+) A-I      intronic chr10:82217071(+) A-I      intronic chr10:82235617(+) A-I      intronic chr10:82243478(+) A-I      intronic chr10:82243479(+) A-I      intronic chr10:82241691(+) A-I      intronic chr10:82243607(+) A-I      intronic chr10:82243618(+) A-I      intronic chr10:82241716(+) A-I      intronic chr10:82243750(+) A-I      intronic chr10:82235211(+) A-I      intronic chr10:82243760(+) A-I      intronic chr10:82243455(+) A-I      intronic chr10:82243745(+) A-I      intronic chr10:82243801(+) A-I      intronic chr10:82243842(+) A-I      intronic chr10:82243577(+) A-I      intronic chr10:82243481(+) A-I      intronic chr10:82243890(+) A-I      intronic chr10:82244174(+) A-I      intronic chr10:82235059(+) A-I      intronic chr10:82240755(+) A-I      intronic chr10:82244181(+) A-I      intronic chr10:82235163(+) A-I      intronic chr10:82243912(+) A-I      intronic chr10:82243921(+) A-I      intronic chr10:82244158(+) A-I      intronic chr10:82244240(+) A-I      intronic chr10:82243840(+) A-I      intronic chr10:82271643(+) A-I      intronic chr10:82240773(+) A-I      intronic chr10:82243410(+) A-I      intronic chr10:82243507(+) A-I      intronic chr10:82243407(+) A-I      intronic chr10:82243449(+) A-I      intronic chr10:82241649(+) A-I      intronic chr10:82243578(+) A-I      intronic chr10:82243519(+) A-I      intronic chr10:82282152(+) A-I      3'UTR chr10:82282216(+) A-I      3'UTR chr10:82282033(+) A-I      3'UTR chr10:82282128(+) A-I      3'UTR chr10:82282091(+) A-I      3'UTR chr10:82282038(+) A-I      3'UTR chr10:82282028(+) A-I      3'UTR chr10:82281669(+) A-I      3'UTR chr10:82282179(+) A-I      3'UTR chr10:82282188(+) A-I      3'UTR chr10:82282209(+) A-I      3'UTR chr10:82282173(+) A-I      3'UTR chr10:82282199(+) A-I      3'UTR chr10:82235970(+) A-I      intronic chr10:82243654(+) A-I      intronic chr10:82235195(+) A-I      intronic chr10:82271654(+) A-I      intronic chr10:82244210(+) A-I      intronic chr10:82243572(+) A-I      intronic chr10:82244257(+) A-I      intronic chr10:82241521(+) A-I      intronic chr10:82243854(+) A-I      intronic chr10:82240750(+) A-I      intronic chr10:82243942(+) A-I      intronic chr10:82235049(+) A-I      intronic chr10:82243415(+) A-I      intronic chr10:82243766(+) A-I      intronic chr10:82243527(+) A-I      intronic chr10:82270551(+) A-I      intronic chr10:82243851(+) A-I      intronic chr10:82243908(+) A-I      intronic chr10:82240767(+) A-I      intronic chr10:82215549(+) A-I      intronic chr10:82235967(+) A-I      intronic chr10:82246762(+) A-I      intronic chr10:82243744(+) A-I      intronic chr10:82252385(+) A-I      intronic chr10:82235476(+) A-I      intronic chr10:82240793(+) A-I      intronic chr10:82236008(+) A-I      intronic chr10:82244180(+) A-I      intronic chr10:82231749(+) A-I      intronic chr10:82235942(+) A-I      intronic chr10:82216564(+) A-I      intronic chr10:82243440(+) A-I      intronic chr10:82228542(+) A-I      intronic chr10:82235365(+) A-I      intronic chr10:82235557(+) A-I      intronic chr10:82243841(+) A-I      intronic chr10:82241627(+) A-I      intronic chr10:82244235(+) A-I      intronic chr10:82243825(+) A-I      intronic chr10:82243815(+) A-I      intronic chr10:82243848(+) A-I      intronic chr10:82235995(+) A-I      intronic chr10:82241675(+) A-I      intronic chr10:82243501(+) A-I      intronic chr10:82243903(+) A-I      intronic chr10:82235946(+) A-I      intronic chr10:82241639(+) A-I      intronic chr10:82235140(+) A-I      intronic chr10:82243516(+) A-I      intronic chr10:82240741(+) A-I      intronic chr10:82243916(+) A-I      intronic chr10:82235164(+) A-I      intronic chr10:82244185(+) A-I      intronic chr10:82243489(+) A-I      intronic chr10:82240715(+) A-I      intronic chr10:82235126(+) A-I      intronic chr10:82243546(+) A-I      intronic chr10:82244217(+) A-I      intronic chr10:82243545(+) A-I      intronic chr10:82228526(+) A-I      intronic chr10:82235065(+) A-I      intronic chr10:82274988(+) A-I      intronic chr10:82282102(+) A-I      3'UTR chr10:82282105(+) A-I      3'UTR chr10:82282146(+) A-I      3'UTR chr10:82282081(+) A-I      3'UTR chr10:82282011(+) A-I      3'UTR chr10:82275015(+) A-I      intronic chr10:82282042(+) A-I      3'UTR chr10:82275009(+) A-I      intronic chr10:82282163(+) A-I      3'UTR chr10:82281533(+) A-I      3'UTR chr10:82281989(+) A-I      3'UTR chr10:82281559(+) A-I      3'UTR chr10:82275092(+) A-I      intronic chr10:82226285(+) A-I      5'UTR chr10:82274682(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TSPAN14	chr10:82214067-82214068(+) m6A 5'UTR       24209618//24981863 chr10:82219075-82219076(+) m6A 5'UTR//intron       24209618//24981863 chr10:82277697-82277698(+) m6A CDS//exon       24284625//26404942 chr10:82277898-82277899(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82277927-82277928(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82277962-82277963(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278003-82278004(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278044-82278045(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278073-82278074(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278104-82278105(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278153-82278154(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278167-82278168(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278271-82278272(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278345-82278346(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr10:82278412-82278413(+) m6A 3'UTR//exon       24209618//25456834//24981863//22575960//22608085 chr10:82278651-82278652(+) m6A 3'UTR//exon       24284625//24209618//24981863//27773535 chr10:82278852-82278853(+) m6A 3'UTR//exon       - chr10:82279175-82279176(+) m6A 3'UTR//exon       26404942 chr10:82279466-82279467(+) m6A 3'UTR       - chr10:82279487-82279488(+) m6A 3'UTR       - chr10:82280428-82280429(+) m6A 3'UTR       24981863 chr10:82280588-82280589(+) m6A 3'UTR       24981863 chr10:82280967-82280968(+) m6A 3'UTR       24284625 chr10:82281005-82281006(+) m6A 3'UTR       24284625 chr10:82281736-82281737(+) m6A 3'UTR       24981863//26404942//27773535 chr10:82281757-82281758(+) m6A 3'UTR       24209618//24981863//26404942//27773535 chr10:82281892-82281893(+) m6A 3'UTR       24209618//24981863//26404942 chr10:82281981-82281982(+) m6A 3'UTR       25456834//24981863 chr10:82282019-82282020(+) m6A 3'UTR       24284625//25456834//24981863 chr10:82282035-82282036(+) m6A 3'UTR       24284625//25456834//24981863 chr10:82282067-82282068(+) m6A 3'UTR       24284625//25456834//24981863 chr10:82282077-82282078(+) m6A 3'UTR       24284625//25456834//24981863 chr10:82282187-82282188(+) m6A 3'UTR       24981863//27773535 chr10:82282196-82282197(+) m6A 3'UTR       24981863//27773535 chr10:82282253-82282254(+) m6A 3'UTR       24981863//27773535 chr10:82282284-82282285(+) m6A 3'UTR       24981863//27773535 chr10:82282310-82282311(+) m6A 3'UTR       24981863//27773535 chr10:82282320-82282321(+) m6A 3'UTR       24981863//27773535 chr10:82282331-82282332(+) m6A 3'UTR       24981863//27773535 chr10:82282370-82282371(+) m6A 3'UTR       24981863//27773535 chr10:82285742-82285743(+) m6A 3'UTR       24981863 chr10:82285750-82285751(+) m6A 3'UTR       24981863 chr10:82285795-82285796(+) m6A 3'UTR       24981863 chr10:82287822-82287823(+) m6A 3'UTR       24981863 chr10:82287863-82287864(+) m6A 3'UTR       24981863 chr10:82288340-82288341(+) m6A 3'UTR       - chr10:82288443-82288444(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TSPAN14	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-11-3p
Interactor2: TSPAN14

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).