Detail Information

Basic Information:


  VIRBase ID:  

VHID00429989

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5908

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-3p:           DSTYK:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-11-3p DSTYK
miRBase
Accession/Entrez ID		 MIMAT0002181 25778
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - CAKUT1//DustyPK//HDCMD38P//RIP5//RIPK5//SPG23

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DSTYK
chr1:205142952(-) A-I      intronic
chr1:205142949(-) A-I      intronic
chr1:205142975(-) A-I      intronic
chr1:205142985(-) A-I      intronic
chr1:205142958(-) A-I      intronic
chr1:205142967(-) A-I      intronic
chr1:205172962(-) A-I      intronic
chr1:205172961(-) A-I      intronic
chr1:205171008(-) A-I      intronic
chr1:205170240(-) A-I      intronic
chr1:205170227(-) A-I      intronic
chr1:205170226(-) A-I      intronic
chr1:205170221(-) A-I      intronic
chr1:205169591(-) A-I      intronic
chr1:205169551(-) A-I      intronic
chr1:205169313(-) A-I      intronic
chr1:205166043(-) A-I      intronic
chr1:205166025(-) A-I      intronic
chr1:205166024(-) A-I      intronic
chr1:205165563(-) A-I      intronic
chr1:205165519(-) A-I      intronic
chr1:205165511(-) A-I      intronic
chr1:205154614(-) A-I      intronic
chr1:205154325(-) A-I      intronic
chr1:205154220(-) A-I      intronic
chr1:205154217(-) A-I      intronic
chr1:205154091(-) A-I      intronic
chr1:205153780(-) A-I      intronic
chr1:205150974(-) A-I      intronic
chr1:205149665(-) A-I      intronic
chr1:205143012(-) A-I      intronic
chr1:205142971(-) A-I      intronic
chr1:205142436(-) A-I      intronic
chr1:205142435(-) A-I      intronic
chr1:205133504(-) A-I      intronic
chr1:205128292(-) A-I      intronic
chr1:205145860(-) A-I      intronic
chr1:205177745(-) A-I      intronic
chr1:205177143(-) A-I      intronic
chr1:205177006(-) A-I      intronic
chr1:205177071(-) A-I      intronic
chr1:205134264(-) A-I      intronic
chr1:205143759(-) A-I      intronic
chr1:205150659(-) A-I      intronic
chr1:205150661(-) A-I      intronic
chr1:205146168(-) A-I      intronic
chr1:205126720(-) A-I      intronic
chr1:205148003(-) A-I      intronic
chr1:205172502(-) A-I      intronic
chr1:205141357(-) A-I      intronic
chr1:205146104(-) A-I      intronic
chr1:205148188(-) A-I      intronic
chr1:205154567(-) A-I      intronic
chr1:205165635(-) A-I      intronic
chr1:205172515(-) A-I      intronic
chr1:205171065(-) A-I      intronic
chr1:205144416(-) A-I      intronic
chr1:205150942(-) A-I      intronic
chr1:205149820(-) A-I      intronic
chr1:205114651(-) A-I      3'UTR
chr1:205171105(-) A-I      intronic
chr1:205148181(-) A-I      intronic
chr1:205168045(-) A-I      intronic
chr1:205165983(-) A-I      intronic
chr1:205146142(-) A-I      intronic
chr1:205164099(-) A-I      intronic
chr1:205124283(-) A-I      intronic
chr1:205135064(-) A-I      intronic
chr1:205169452(-) A-I      intronic
chr1:205143289(-) A-I      intronic
chr1:205146332(-) A-I      intronic
chr1:205143123(-) A-I      intronic
chr1:205171016(-) A-I      intronic
chr1:205153617(-) A-I      intronic
chr1:205132636(-) A-I      intronic
chr1:205124259(-) A-I      intronic
chr1:205150934(-) A-I      intronic
chr1:205171075(-) A-I      intronic
chr1:205135546(-) A-I      intronic
chr1:205128285(-) A-I      intronic
chr1:205141685(-) A-I      intronic
chr1:205169303(-) A-I      intronic
chr1:205177767(-) A-I      intronic
chr1:205169521(-) A-I      intronic
chr1:205134961(-) A-I      intronic
chr1:205150665(-) A-I      intronic
chr1:205143962(-) A-I      intronic
chr1:205177835(-) A-I      intronic
chr1:205164029(-) A-I      intronic
chr1:205166002(-) A-I      intronic
chr1:205171111(-) A-I      intronic
chr1:205161968(-) A-I      intronic
chr1:205161943(-) A-I      intronic
chr1:205134289(-) A-I      intronic
chr1:205141136(-) A-I      intronic
chr1:205148006(-) A-I      intronic
chr1:205150679(-) A-I      intronic
chr1:205142439(-) A-I      intronic
chr1:205134324(-) A-I      intronic
chr1:205146213(-) A-I      intronic
chr1:205170976(-) A-I      intronic
chr1:205148555(-) A-I      intronic
chr1:205169574(-) A-I      intronic
chr1:205161951(-) A-I      intronic
chr1:205153588(-) A-I      intronic
chr1:205112269(-) A-I      3'UTR
chr1:205133487(-) A-I      intronic
chr1:205143067(-) A-I      intronic
chr1:205177847(-) A-I      intronic
chr1:205169302(-) A-I      intronic
chr1:205144138(-) A-I      intronic
chr1:205148559(-) A-I      intronic
chr1:205177070(-) A-I      intronic
chr1:205135529(-) A-I      intronic
chr1:205148189(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DSTYK
chr1:205148555(-) A-I intron -    15545495
chr1:205148559(-) A-I intron -    15545495
chr1:205177799(-) A-I intron -    21960545
chr1:205124232(-) G-C intron -    22484847
chr1:205124259(-) A-G intron -    22484847
chr1:205124274(-) T-C intron -    22484847
chr1:205124283(-) A-G intron -    22484847
chr1:205134264(-) A-G intron -    22484847
chr1:205143067(-) A-G intron -    22484847
chr1:205143123(-) A-G intron -    22484847
chr1:205143289(-) A-G intron -    22484847
chr1:205143759(-) A-G intron -    22484847
chr1:205143867(-) T-A intron -    22484847
chr1:205150659(-) A-G intron -    22484847
chr1:205150661(-) A-G intron -    22484847
chr1:205150665(-) A-G intron -    22484847
chr1:205150679(-) A-G intron -    22484847
chr1:205153617(-) A-G intron -    22484847
chr1:205171016(-) A-G intron -    22484847
chr1:205171065(-) A-G intron -    22484847
chr1:205171075(-) A-G intron -    22484847
chr1:205171105(-) A-G intron -    22484847
chr1:205171111(-) A-G intron -    22484847
chr1:205172914(-) A-C intron -    22484847
chr1:205177835(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DSTYK
chr1:205116080-205116081(-) m6A 3'UTR       27773535
chr1:205116127-205116128(-) m6A 3'UTR       27773535
chr1:205116215-205116216(-) m6A 3'UTR       27773535
chr1:205116221-205116222(-) m6A 3'UTR       27773535
chr1:205116229-205116230(-) m6A 3'UTR       27773535
chr1:205116266-205116267(-) m6A 3'UTR       27773535
chr1:205116341-205116342(-) m6A 3'UTR       27773535
chr1:205116353-205116354(-) m6A 3'UTR       27773535
chr1:205116526-205116527(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205116553-205116554(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205116560-205116561(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205116578-205116579(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205116594-205116595(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205116676-205116677(-) m6A 3'UTR       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr1:205116703-205116704(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr1:205116710-205116711(-) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr1:205132927-205132928(-) m6A CDS//intron       24284625
chr1:205138324-205138325(-) m6A CDS//intron       27773535//22608085
chr1:205138347-205138348(-) m6A CDS//intron       24284625//24981863//27773535//22575960//22608085
chr1:205138466-205138467(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:205138526-205138527(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138557-205138558(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138591-205138592(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138609-205138610(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138658-205138659(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138745-205138746(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138765-205138766(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205138846-205138847(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:205156578-205156579(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//22608085
chr1:205156609-205156610(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//22575960//22608085
chr1:205156643-205156644(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205156683-205156684(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205156692-205156693(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205156718-205156719(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205156724-205156725(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr1:205156873-205156874(-) m6A CDS       24284625//24209618//24981863
chr1:205180413-205180414(-) m6A CDS       24284625//24981863//27773536
chr1:205180521-205180522(-) m6A CDS       24981863//27371828//27773536
chr1:205180532-205180533(-) m6A CDS       24981863//27371828//27773536
chr1:205180680-205180681(-) m6A 5'UTR       25456834//24981863//27371828//27773536//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate DSTYK
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-11-3p
Interactor2: DSTYK

Evidence Support:


Weak-Evidence Microarray
Prediction-Evidence PicTar//Targetscan
Support Database ViRBase//VmiReg

References:


PMID 18075594 Target region 3'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BJAB cells Interactor2 expression Downregulation
Description Cytoplasmic RNA was isolated from BJAB cells and analyzed on microarrays in three independent experiments. Expression of miR-K12-11 resulted in the downregulation of 181 mRNAs and the upregulation of 86 mRNAs (|T-score| ≥2.86, p≤0.01).Downregulated mRNAs carrying a >6 nt seed match to miR-K12-11 were considered candidate direct targets and are listed in Suppl. Table 1.

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