Detail Information

Basic Information:


  VIRBase ID:  

VHID00429707

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.5711

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-3p:           DBF4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-11-3p DBF4
miRBase
Accession/Entrez ID		 MIMAT0002181 10926
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - ASK//CHIF//DBF4A//ZDBF1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DBF4
chr7:87535366(+) A-I      intronic
chr7:87535344(+) A-I      intronic
chr7:87527927(+) A-I      intronic
chr7:87534366(+) A-I      intronic
chr7:87533221(+) A-I      intronic
chr7:87533220(+) A-I      intronic
chr7:87533194(+) A-I      intronic
chr7:87510571(+) A-I      intronic
chr7:87510569(+) A-I      intronic
chr7:87527943(+) A-I      intronic
chr7:87527999(+) A-I      intronic
chr7:87528002(+) A-I      intronic
chr7:87518002(+) A-I      intronic
chr7:87509147(+) A-I      intronic
chr7:87528076(+) A-I      intronic
chr7:87509115(+) A-I      intronic
chr7:87508511(+) A-I      intronic
chr7:87518612(+) A-I      intronic
chr7:87518648(+) A-I      intronic
chr7:87508484(+) A-I      intronic
chr7:87522641(+) A-I      intronic
chr7:87522700(+) A-I      intronic
chr7:87522759(+) A-I      intronic
chr7:87522767(+) A-I      intronic
chr7:87522771(+) A-I      intronic
chr7:87522820(+) A-I      intronic
chr7:87508416(+) A-I      intronic
chr7:87510444(+) A-I      intronic
chr7:87508393(+) A-I      intronic
chr7:87508337(+) A-I      intronic
chr7:87518778(+) A-I      intronic
chr7:87518675(+) A-I      intronic
chr7:87509117(+) A-I      intronic
chr7:87518816(+) A-I      intronic
chr7:87519762(+) A-I      intronic
chr7:87519767(+) A-I      intronic
chr7:87523585(+) A-I      intronic
chr7:87508516(+) A-I      intronic
chr7:87509126(+) A-I      intronic
chr7:87523700(+) A-I      intronic
chr7:87519590(+) A-I      intronic
chr7:87527145(+) A-I      intronic
chr7:87523572(+) A-I      intronic
chr7:87523628(+) A-I      intronic
chr7:87513564(+) A-I      intronic
chr7:87533937(+) A-I      intronic
chr7:87533250(+) A-I      intronic
chr7:87523575(+) A-I      intronic
chr7:87523701(+) A-I      intronic
chr7:87519684(+) A-I      intronic
chr7:87534302(+) A-I      intronic
chr7:87523644(+) A-I      intronic
chr7:87509066(+) A-I      intronic
chr7:87518664(+) A-I      intronic
chr7:87527290(+) A-I      intronic
chr7:87527293(+) A-I      intronic
chr7:87518674(+) A-I      intronic
chr7:87508332(+) A-I      intronic
chr7:87527219(+) A-I      intronic
chr7:87519779(+) A-I      intronic
chr7:87523564(+) A-I      intronic
chr7:87534359(+) A-I      intronic
chr7:87527882(+) A-I      intronic
chr7:87528069(+) A-I      intronic
chr7:87527138(+) A-I      intronic
chr7:87534395(+) A-I      intronic
chr7:87534291(+) A-I      intronic
chr7:87523509(+) A-I      intronic
chr7:87519727(+) A-I      intronic
chr7:87527111(+) A-I      intronic
chr7:87527909(+) A-I      intronic
chr7:87527197(+) A-I      intronic
chr7:87535267(+) A-I      intronic
chr7:87527193(+) A-I      intronic
chr7:87533936(+) A-I      intronic
chr7:87523584(+) A-I      intronic
chr7:87509065(+) A-I      intronic
chr7:87523632(+) A-I      intronic
chr7:87519768(+) A-I      intronic
chr7:87508492(+) A-I      intronic
chr7:87527276(+) A-I      intronic
chr7:87533136(+) A-I      intronic
chr7:87527273(+) A-I      intronic
chr7:87519726(+) A-I      intronic
chr7:87510493(+) A-I      intronic
chr7:87534405(+) A-I      intronic
chr7:87527919(+) A-I      intronic
chr7:87527218(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DBF4
chr7:87527138(+) A-I intron -    22327324
chr7:87523509(+) A-I intron -    22028664
chr7:87523521(+) A-I intron -    22028664
chr7:87523572(+) A-I intron -    22028664
chr7:87523575(+) A-I intron -    22028664
chr7:87523584(+) A-I intron -    22028664
chr7:87523585(+) A-I intron -    22028664
chr7:87523612(+) A-I intron -    22028664
chr7:87523628(+) A-I intron -    22028664
chr7:87523632(+) A-I intron -    22028664
chr7:87523644(+) A-I intron -    22028664
chr7:87523654(+) A-I intron -    22028664
chr7:87523700(+) A-I intron -    22028664
chr7:87523701(+) A-I intron -    22028664
chr7:87508332(+) A-G intron -    22484847
chr7:87508447(+) A-G intron -    22484847
chr7:87508492(+) A-G intron -    22484847
chr7:87509038(+) A-G intron -    22484847
chr7:87509041(+) T-C intron -    22484847
chr7:87509057(+) A-G intron -    22484847
chr7:87509065(+) A-G intron -    22484847
chr7:87509066(+) A-G intron -    22484847
chr7:87509126(+) A-G intron -    22484847
chr7:87518724(+) A-G intron -    22484847
chr7:87519590(+) A-G intron -    22484847
chr7:87519726(+) A-G intron -    22484847
chr7:87519727(+) A-G intron -    22484847
chr7:87519735(+) T-C intron -    22484847
chr7:87519768(+) A-G intron -    22484847
chr7:87523509(+) A-G intron -    22484847
chr7:87523584(+) A-G intron -    22484847
chr7:87523585(+) A-G intron -    22484847
chr7:87523654(+) A-G intron -    22484847
chr7:87523701(+) A-G intron -    22484847
chr7:87527138(+) A-G intron -    22484847
chr7:87527145(+) A-G intron -    22484847
chr7:87527210(+) A-G intron -    22484847
chr7:87527218(+) A-G intron -    22484847
chr7:87527230(+) T-C intron -    22484847
chr7:87527257(+) T-C intron -    22484847
chr7:87527268(+) T-C intron -    22484847
chr7:87527269(+) T-C intron -    22484847
chr7:87527276(+) A-G intron -    22484847
chr7:87527281(+) T-C intron -    22484847
chr7:87527290(+) A-G intron -    22484847
chr7:87527293(+) A-G intron -    22484847
chr7:87527345(+) A-G intron -    22484847
chr7:87527852(+) A-G intron -    22484847
chr7:87527882(+) A-G intron -    22484847
chr7:87528069(+) A-G intron -    22484847
chr7:87532420(+) T-C intron -    22484847
chr7:87533214(+) T-C intron -    22484847
chr7:87533974(+) T-C intron -    22484847
chr7:87534011(+) T-C intron -    22484847
chr7:87534291(+) A-G intron -    22484847
chr7:87534302(+) A-G intron -    22484847
chr7:87534359(+) A-G intron -    22484847
chr7:87535390(+) T-C intron -    22484847
chr7:87517988(+) A-G intron -    22484847
chr7:87517989(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DBF4
chr7:87505563-87505564(+) m6A 5'UTR       25456834
chr7:87505577-87505578(+) m6A 5'UTR       25456834
chr7:87505597-87505598(+) m6A 5'UTR       25456834
chr7:87505637-87505638(+) m6A 5'UTR       25456834
chr7:87505888-87505889(+) m6A 5'UTR//exon       24981863
chr7:87517316-87517317(+) m6A 3'UTR//CDS//exon       24981863
chr7:87525534-87525535(+) m6A exon//intron       24981863
chr7:87533712-87533713(+) m6A 3'UTR//CDS//exon       24981863//27773535//22608085
chr7:87536557-87536558(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87536562-87536563(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87536656-87536657(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87536665-87536666(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87536787-87536788(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr7:87536819-87536820(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr7:87536823-87536824(+) m6A 3'UTR//CDS       27773535//22575960
chr7:87536850-87536851(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr7:87536880-87536881(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:87536967-87536968(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:87537017-87537018(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr7:87537062-87537063(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr7:87537123-87537124(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr7:87537225-87537226(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87537250-87537251(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87537275-87537276(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87537311-87537312(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085
chr7:87537322-87537323(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate DBF4
Chromatin K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-11-3p
Interactor2: DBF4

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence PARalyzer
Support Database ViRBase//VIRmiRNA

References:


PMID 22100165 Target region 3'UTR
Source ViRBase//VIRmiRNA Interactor1 expression None
Tissue or cell line BC-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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