Basic Information:

  VIRBase ID:  

VHID00429229

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-3p:  MIMAT0002181          ZFP36:  NM_003407     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-11-3p	ZFP36
miRBase Accession/Entrez ID	MIMAT0002181	7538
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	G0S24//GOS24//NUP475//RNF162A//TIS11//TTP//zfp-36

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZFP36	chr19:39897641-39897642(+) m6A CDS//intron       24981863 chr19:39897729-39897730(+) m6A CDS//intron       24981863 chr19:39898093-39898094(+) m6A CDS//intron       25456834//24981863 chr19:39898100-39898101(+) m6A CDS//intron       25456834//24981863 chr19:39898115-39898116(+) m6A CDS//intron       25456834 chr19:39898433-39898434(+) m6A 3'UTR//CDS       25456834 chr19:39898465-39898466(+) m6A 3'UTR//CDS       24284625 chr19:39898673-39898674(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942 chr19:39898688-39898689(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942 chr19:39898792-39898793(+) m6A 3'UTR//CDS       24284625//25456834//24981863//26404942 chr19:39898869-39898870(+) m6A CDS       24284625//24209618//25456834//24981863//26404942 chr19:39898943-39898944(+) m6A CDS       24284625//24209618//25456834//24981863 chr19:39899028-39899029(+) m6A CDS       24284625//25456834//24981863 chr19:39899088-39899089(+) m6A CDS       24284625//25456834//24981863 chr19:39899168-39899169(+) m6A CDS       24284625//24981863 chr19:39899413-39899414(+) m6A 3'UTR       25456834//24981863//26404942 chr19:39899430-39899431(+) m6A 3'UTR       25456834//24981863//26404942 chr19:39899439-39899440(+) m6A 3'UTR       25456834//24981863//26404942 chr19:39899703-39899704(+) m6A 3'UTR       27773535 chr19:39899735-39899736(+) m6A 3'UTR       27773535 chr19:39899804-39899805(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZFP36	Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-11-3p
Interactor2: ZFP36

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	DG-75 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).