Basic Information:

  VIRBase ID:  

VHID00429074

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-3p:  MIMAT0002181          SRSF3:  NR_036610     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-11-3p	SRSF3
miRBase Accession/Entrez ID	MIMAT0002181	6428
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	SFRS3//SRp20

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SRSF3	chr6:36563776(+) A-I      intronic chr6:36565707(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SRSF3	chr6:36564896(+) G-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SRSF3	chr6:36562205-36562206(+) m6A 5'UTR//exon       24284625//25456834//24981863//27773535 chr6:36564564-36564565(+) m6A CDS//exon       27773535 chr6:36564594-36564595(+) m6A CDS//exon       27773535 chr6:36564640-36564641(+) m6A CDS//exon       22575960 chr6:36564669-36564670(+) m6A CDS//exon       22575960 chr6:36564735-36564736(+) Tm CDS//exon       - chr6:36566655-36566656(+) m6A 3'UTR//CDS//exon       22575960 chr6:36567974-36567975(+) m6A 3'UTR//exon//intron       24284625//24981863//27773535 chr6:36569769-36569770(+) m6A 3'UTR//exon       27773535 chr6:36569849-36569850(+) m6A 3'UTR//exon       27773535 chr6:36569911-36569912(+) m6A 3'UTR//exon       27773535 chr6:36570024-36570025(+) m6A 3'UTR//exon       27773535 chr6:36570042-36570043(+) m6A 3'UTR//exon       27773535 chr6:36570053-36570054(+) m6A 3'UTR//exon       27773535 chr6:36570061-36570062(+) m6A 3'UTR//exon       27773535 chr6:36570178-36570179(+) m6A 3'UTR//exon       26404942 chr6:36570195-36570196(+) m6A 3'UTR//exon       26404942 chr6:36570206-36570207(+) m6A 3'UTR//exon       26404942 chr6:36570943-36570944(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SRSF3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-11-3p
Interactor2: SRSF3

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).