Basic Information:

  VIRBase ID:  

VHID00428944

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-11-3p:  MIMAT0002181          PLCG1:  NM_002660     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-11-3p	PLCG1
miRBase Accession/Entrez ID	MIMAT0002181	5335
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	NCKAP3//PLC-II//PLC1//PLC148//PLCgamma1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PLCG1	chr20:39804196(+) A-I      3'UTR chr20:39768959(+) A-I      intronic chr20:39786821(+) A-I      intronic chr20:39781974(+) A-I      intronic chr20:39782144(+) A-I      intronic chr20:39782371(+) A-I      intronic chr20:39782070(+) A-I      intronic chr20:39800239(+) A-I      intronic chr20:39782416(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PLCG1	chr20:39766428-39766429(+) m6A CDS//exon       - chr20:39788283-39788284(+) m6A CDS//exon       - chr20:39788293-39788294(+) m6A CDS//exon       - chr20:39788314-39788315(+) m6A CDS//exon       - chr20:39788771-39788772(+) Tm CDS//exon       - chr20:39792574-39792575(+) m6A CDS//exon       - chr20:39792723-39792724(+) m6A CDS       - chr20:39793598-39793599(+) m6A CDS       - chr20:39793625-39793626(+) m6A CDS       - chr20:39793658-39793659(+) m6A CDS       - chr20:39794146-39794147(+) m6A CDS//exon       24284625//24981863 chr20:39794885-39794886(+) m6A CDS//exon       - chr20:39794907-39794908(+) m6A CDS//exon       - chr20:39795011-39795012(+) m6A CDS//exon       - chr20:39795208-39795209(+) m6A CDS//exon       - chr20:39795364-39795365(+) m6A CDS//exon       - chr20:39795380-39795381(+) m6A CDS//exon       - chr20:39795426-39795427(+) m6A CDS//exon       - chr20:39796315-39796316(+) m6A exon//intron       - chr20:39797729-39797730(+) m6A CDS//exon       24284625//24209618//24981863 chr20:39797765-39797766(+) m6A CDS//exon       24284625//24209618//24981863 chr20:39798109-39798110(+) m6A CDS//exon       24284625//24209618 chr20:39798124-39798125(+) m6A CDS//exon       24284625//24209618 chr20:39798862-39798863(+) m6A CDS//exon       - chr20:39798873-39798874(+) Am CDS//exon       - chr20:39798894-39798895(+) m6A CDS//exon       - chr20:39798925-39798926(+) m6A exon//intron       - chr20:39800928-39800929(+) Am CDS//intron       - chr20:39802896-39802897(+) m6A CDS//exon//intron       24284625//22608085 chr20:39802926-39802927(+) m6A CDS//exon//intron       24284625//22575960//22608085 chr20:39803119-39803120(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr20:39803135-39803136(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr20:39803207-39803208(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr20:39803289-39803290(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr20:39803295-39803296(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr20:39803363-39803364(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:39803442-39803443(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:39803496-39803497(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr20:39803561-39803562(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr20:39803591-39803592(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr20:39803704-39803705(+) m6A 3'UTR//intron       24209618//25456834//24981863//22608085 chr20:39803738-39803739(+) m6A 3'UTR//intron       24209618//25456834//24981863 chr20:39803855-39803856(+) m6A 3'UTR//intron       - chr20:39803902-39803903(+) m6A 3'UTR//intron       24981863 chr20:39804193-39804194(+) m6A 3'UTR//intron       24284625 chr20:39804263-39804264(+) m6A 3'UTR//intron       24284625 chr20:39814223-39814224(+) m6A exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PLCG1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-11-3p
Interactor2: PLCG1

Evidence Support:

Weak-Evidence	Microarray
Support Database	ViRBase

References:

PMID	22174674	Target region	None
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EA.hy926 cells	Interactor2 expression	Downregulation
Description	As KSHV putative direct targets we extracted transcripts that were significantly down-regulated significantly in the replicate experiments, and which contained at least one seed-match to one of the KSHV miRNAs. We identified 704 putative direct targets in DG-75 cells (Figure 3B), and 980 putative direct targets in EA.hy926 cells (Figure 3C). A complete list of putative direct targets can be found in Dataset S2 for DG-75 cells and in Dataset S3 for EA.hy926 cells. The overlap between the two datasets contained 153 putative direct targets (Dataset S4).