Basic Information:

  VIRBase ID:  

VHID00428221

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:  MIMAT0002180          ZBTB34:  NM_001099270     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10b	ZBTB34
miRBase Accession/Entrez ID	MIMAT0002180	403341
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	ZNF918

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ZBTB34	chr9:129640128(+) A-I      intronic chr9:129641225(+) A-I      intronic chr9:129641238(+) A-I      intronic chr9:129633742(+) A-I      intronic chr9:129633741(+) A-I      intronic chr9:129636045(+) A-I      intronic chr9:129641223(+) A-I      intronic chr9:129640704(+) A-I      intronic chr9:129640694(+) A-I      intronic chr9:129640690(+) A-I      intronic chr9:129633746(+) A-I      intronic chr9:129640494(+) A-I      intronic chr9:129634365(+) A-I      intronic chr9:129640539(+) A-I      intronic chr9:129634413(+) A-I      intronic chr9:129633745(+) A-I      intronic chr9:129640155(+) A-I      intronic chr9:129640198(+) A-I      intronic chr9:129646380(+) A-I      3'UTR chr9:129633113(+) A-I      intronic chr9:129634140(+) A-I      intronic chr9:129640524(+) A-I      intronic chr9:129640176(+) A-I      intronic chr9:129641128(+) A-I      intronic chr9:129640163(+) A-I      intronic chr9:129641265(+) A-I      intronic chr9:129641103(+) A-I      intronic chr9:129641097(+) A-I      intronic chr9:129641183(+) A-I      intronic chr9:129640642(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZBTB34	chr9:129623014-129623015(+) m6A 5'UTR       24284625 chr9:129641651-129641652(+) m6A 5'UTR//intron       24284625//22608085 chr9:129641694-129641695(+) m6A CDS       24284625//24981863//22575960//22608085 chr9:129641761-129641762(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr9:129641779-129641780(+) m6A CDS       24284625//25456834//24981863//22575960//22608085 chr9:129641865-129641866(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129642147-129642148(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642291-129642292(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642342-129642343(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642357-129642358(+) m6A CDS       24284625//25456834//24981863//22608085 chr9:129642484-129642485(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr9:129642732-129642733(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129642927-129642928(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129642967-129642968(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643038-129643039(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643088-129643089(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643105-129643106(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643111-129643112(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643215-129643216(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr9:129643330-129643331(+) m6A 3'UTR       24284625//24981863//22608085 chr9:129643411-129643412(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:129643442-129643443(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr9:129644892-129644893(+) m6A 3'UTR       - chr9:129644935-129644936(+) m6A 3'UTR       - chr9:129644970-129644971(+) m6A 3'UTR       - chr9:129646203-129646204(+) m6A 3'UTR       24284625//24981863 chr9:129646209-129646210(+) m6A 3'UTR       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZBTB34	Exosome Blood     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10b
Interactor2: ZBTB34

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BJAB cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.