Detail Information

Basic Information:


  VIRBase ID:  

VHID00428075

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:           BRWD3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-10b BRWD3
miRBase
Accession/Entrez ID		 MIMAT0002180 254065
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - BRODL//MRX93

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BRWD3
chrX:80051727(-) A-I      intronic
chrX:80003650(-) A-I      intronic
chrX:80006207(-) A-I      intronic
chrX:80051892(-) A-I      intronic
chrX:80051900(-) A-I      intronic
chrX:80058360(-) A-I      intronic
chrX:80045147(-) A-I      intronic
chrX:80051722(-) A-I      intronic
chrX:80051416(-) A-I      intronic
chrX:80049421(-) A-I      intronic
chrX:80045687(-) A-I      intronic
chrX:80045486(-) A-I      intronic
chrX:80007676(-) A-I      intronic
chrX:80045139(-) A-I      intronic
chrX:80045104(-) A-I      intronic
chrX:80045090(-) A-I      intronic
chrX:80045071(-) A-I      intronic
chrX:80045042(-) A-I      intronic
chrX:80045023(-) A-I      intronic
chrX:80045013(-) A-I      intronic
chrX:80042290(-) A-I      intronic
chrX:80042282(-) A-I      intronic
chrX:80042276(-) A-I      intronic
chrX:80042193(-) A-I      intronic
chrX:80041447(-) A-I      intronic
chrX:80041420(-) A-I      intronic
chrX:80041405(-) A-I      intronic
chrX:80041361(-) A-I      intronic
chrX:80038278(-) A-I      intronic
chrX:80038210(-) A-I      intronic
chrX:80035017(-) A-I      intronic
chrX:80034596(-) A-I      intronic
chrX:80033374(-) A-I      intronic
chrX:80033056(-) A-I      intronic
chrX:80033016(-) A-I      intronic
chrX:80016501(-) A-I      intronic
chrX:80010460(-) A-I      intronic
chrX:80010375(-) A-I      intronic
chrX:80010358(-) A-I      intronic
chrX:80010326(-) A-I      intronic
chrX:80010303(-) A-I      intronic
chrX:80010271(-) A-I      intronic
chrX:80008946(-) A-I      intronic
chrX:80052462(-) A-I      intronic
chrX:80051809(-) A-I      intronic
chrX:80051732(-) A-I      intronic
chrX:80008907(-) A-I      intronic
chrX:80008906(-) A-I      intronic
chrX:80008829(-) A-I      intronic
chrX:80008301(-) A-I      intronic
chrX:80007729(-) A-I      intronic
chrX:80007712(-) A-I      intronic
chrX:80045654(-) A-I      intronic
chrX:80042207(-) A-I      intronic
chrX:80033422(-) A-I      intronic
chrX:80033080(-) A-I      intronic
chrX:80008302(-) A-I      intronic
chrX:79969823(-) A-I      intronic
chrX:80016544(-) A-I      intronic
chrX:80057326(-) A-I      intronic
chrX:80057094(-) A-I      intronic
chrX:80007681(-) A-I      intronic
chrX:79991050(-) A-I      intronic
chrX:80035065(-) A-I      intronic
chrX:79963859(-) A-I      intronic
chrX:80042152(-) A-I      intronic
chrX:80010340(-) A-I      intronic
chrX:80010424(-) A-I      intronic
chrX:80034479(-) A-I      intronic
chrX:80045039(-) A-I      intronic
chrX:80034620(-) A-I      intronic
chrX:80029820(-) A-I      intronic
chrX:80045601(-) A-I      intronic
chrX:80010348(-) A-I      intronic
chrX:80045639(-) A-I      intronic
chrX:80056987(-) A-I      intronic
chrX:80041522(-) A-I      intronic
chrX:80035090(-) A-I      intronic
chrX:80057234(-) A-I      intronic
chrX:80033130(-) A-I      intronic
chrX:80056910(-) A-I      intronic
chrX:80053405(-) A-I      intronic
chrX:80051901(-) A-I      intronic
chrX:80059797(-) A-I      intronic
chrX:80045602(-) A-I      intronic
chrX:80010288(-) A-I      intronic
chrX:80010407(-) A-I      intronic
chrX:80016540(-) A-I      intronic
chrX:80042281(-) A-I      intronic
chrX:80045553(-) A-I      intronic
chrX:80041446(-) A-I      intronic
chrX:80041344(-) A-I      intronic
chrX:80045070(-) A-I      intronic
chrX:80057743(-) A-I      intronic
chrX:80056843(-) A-I      intronic
chrX:80014282(-) A-I      intronic
chrX:80033064(-) A-I      intronic
chrX:80059822(-) A-I      intronic
chrX:80051335(-) A-I      intronic
chrX:80029854(-) A-I      intronic
chrX:80045515(-) A-I      intronic
chrX:80045561(-) A-I      intronic
chrX:80052425(-) A-I      intronic
chrX:79963843(-) A-I      intronic
chrX:80041417(-) A-I      intronic
chrX:79969829(-) A-I      intronic
chrX:80035066(-) A-I      intronic
chrX:80045080(-) A-I      intronic
chrX:80042196(-) A-I      intronic
chrX:80045573(-) A-I      intronic
chrX:80034315(-) A-I      intronic
chrX:80009042(-) A-I      intronic
chrX:80041276(-) A-I      intronic
chrX:80035092(-) A-I      intronic
chrX:80033135(-) A-I      intronic
chrX:80007660(-) A-I      intronic
chrX:80051741(-) A-I      intronic
chrX:80016519(-) A-I      intronic
chrX:80045641(-) A-I      intronic
chrX:80045512(-) A-I      intronic
chrX:80045557(-) A-I      intronic
chrX:80056816(-) A-I      intronic
chrX:80059901(-) A-I      intronic
chrX:80032941(-) A-I      intronic
chrX:80042151(-) A-I      intronic
chrX:80061241(-) A-I      intronic
chrX:80034970(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED BRWD3
chrX:80006320(-) A-G intron -    22484847
chrX:80007627(-) A-G intron -    22484847
chrX:80041429(-) A-G intron -    22484847
chrX:80042110(-) A-G intron -    22484847
chrX:80042111(-) A-G intron -    22484847
chrX:80042196(-) A-G intron -    22484847
chrX:80042281(-) A-G intron -    22484847
chrX:80045601(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BRWD3
chrX:79931816-79931817(-) m6A 3'UTR       24981863//22608085
chrX:79931827-79931828(-) m6A 3'UTR       24981863//22608085
chrX:79931842-79931843(-) m6A 3'UTR       24284625//24981863//22608085
chrX:79931870-79931871(-) m6A 3'UTR       24284625//24981863//22608085
chrX:79931956-79931957(-) m6A 3'UTR       24284625//22608085
chrX:79932016-79932017(-) m6A 3'UTR       22608085
chrX:79932176-79932177(-) Cm CDS       -
chrX:79932250-79932251(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22608085
chrX:79932264-79932265(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22575960//22608085
chrX:79932271-79932272(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22575960//22608085
chrX:79932287-79932288(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//22575960//22608085
chrX:79932517-79932518(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22608085
chrX:79932557-79932558(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932569-79932570(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932574-79932575(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932600-79932601(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932625-79932626(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//22575960//22608085
chrX:79932733-79932734(-) m6A CDS       24284625//24981863//28052920//27371828//22575960//22608085
chrX:79932765-79932766(-) m6A CDS//exon       24284625//24981863//28052920//27371828//22608085
chrX:79932794-79932795(-) m6A CDS//exon       24284625//24981863//28052920//27371828//22608085
chrX:79932811-79932812(-) m6A CDS//exon       24284625//24981863//28052920//27371828//22608085
chrX:79932845-79932846(-) m6A CDS//exon       24284625//24981863//27371828//22608085
chrX:79936843-79936844(-) m6A CDS//exon       24981863//22608085
chrX:79959083-79959084(-) m6A CDS//exon       24981863
chrX:79960187-79960188(-) m6A CDS//exon       24981863
chrX:79960197-79960198(-) m6A CDS//exon       24981863
chrX:79960269-79960270(-) m6A CDS//exon       24981863
chrX:79960278-79960279(-) m6A CDS//exon       24981863
chrX:79960316-79960317(-) m6A CDS//exon       24981863
chrX:79971729-79971730(-) m6A CDS//exon       24981863
chrX:79975048-79975049(-) m6A CDS//exon       24981863
chrX:79975055-79975056(-) m6A CDS//exon       24981863
chrX:79975060-79975061(-) m6A CDS//exon       24981863
chrX:79980471-79980472(-) m6A CDS       -
chrX:79980486-79980487(-) m6A CDS       -
chrX:79980563-79980564(-) m6A CDS       -
chrX:79985459-79985460(-) Am CDS       -
chrX:80064765-80064766(-) m6A CDS//exon       27773536
chrX:80065068-80065069(-) m6A 5'UTR//exon       -
chrX:80065100-80065101(-) m6A 5'UTR//exon       -

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate BRWD3
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome HeLa cells     24205503
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-10b
Interactor2: BRWD3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database VIRmiRNA

References:


PMID 22100165 Target region 3'UTR
Source VIRmiRNA Interactor1 expression None
Tissue or cell line BC-1 cells//BC-3 cells//BCBL-1 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.

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