Basic Information:

  VIRBase ID:  

VHID00427875

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:  MIMAT0002180          VPS37A:  NM_152415     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10b	VPS37A
miRBase Accession/Entrez ID	MIMAT0002180	137492
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCRP1//PQBP2//SPG53

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	VPS37A	chr8:17112825(+) A-I      intronic chr8:17112830(+) A-I      intronic chr8:17112831(+) A-I      intronic chr8:17120394(+) A-I      intronic chr8:17109737(+) A-I      intronic chr8:17109721(+) A-I      intronic chr8:17104982(+) A-I      intronic chr8:17124356(+) A-I      intronic chr8:17124361(+) A-I      intronic chr8:17124399(+) A-I      intronic chr8:17148584(+) A-I      intronic chr8:17148774(+) A-I      intronic chr8:17148783(+) A-I      intronic chr8:17109725(+) A-I      intronic chr8:17112806(+) A-I      intronic chr8:17121224(+) A-I      intronic chr8:17109730(+) A-I      intronic chr8:17148784(+) A-I      intronic chr8:17112780(+) A-I      intronic chr8:17109749(+) A-I      intronic chr8:17109746(+) A-I      intronic chr8:17155353(+) A-I      3'UTR chr8:17155389(+) A-I      3'UTR chr8:17153744(+) A-I      3'UTR chr8:17155364(+) A-I      3'UTR chr8:17155363(+) A-I      3'UTR chr8:17155354(+) A-I      3'UTR chr8:17155380(+) A-I      3'UTR chr8:17155405(+) A-I      3'UTR chr8:17155384(+) A-I      3'UTR chr8:17153808(+) A-I      3'UTR chr8:17155385(+) A-I      3'UTR chr8:17153751(+) A-I      3'UTR chr8:17155392(+) A-I      3'UTR chr8:17155361(+) A-I      3'UTR chr8:17155391(+) A-I      3'UTR chr8:17153809(+) A-I      3'UTR chr8:17109787(+) A-I      intronic chr8:17105913(+) A-I      intronic chr8:17124462(+) A-I      intronic chr8:17148587(+) A-I      intronic chr8:17109800(+) A-I      intronic chr8:17124519(+) A-I      intronic chr8:17120449(+) A-I      intronic chr8:17121439(+) A-I      intronic chr8:17124511(+) A-I      intronic chr8:17120316(+) A-I      intronic chr8:17121319(+) A-I      intronic chr8:17114314(+) A-I      intronic chr8:17124382(+) A-I      intronic chr8:17148597(+) A-I      intronic chr8:17124302(+) A-I      intronic chr8:17128860(+) A-I      intronic chr8:17112955(+) A-I      intronic chr8:17114262(+) A-I      intronic chr8:17112804(+) A-I      intronic chr8:17109705(+) A-I      intronic chr8:17112869(+) A-I      intronic chr8:17112922(+) A-I      intronic chr8:17112905(+) A-I      intronic chr8:17121357(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	VPS37A	chr8:17109705(+) A-G intron -    22484847 chr8:17109800(+) A-G intron -    22484847 chr8:17112804(+) A-G intron -    22484847 chr8:17112814(+) A-G intron -    22484847 chr8:17112869(+) A-G intron -    22484847 chr8:17112870(+) A-G intron -    22484847 chr8:17112905(+) A-G intron -    22484847 chr8:17112931(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	VPS37A	chr8:17104229-17104230(+) m6A 5'UTR       24981863//27371828 chr8:17104293-17104294(+) m6A 5'UTR       24981863//27371828//27773536 chr8:17104523-17104524(+) m6A 5'UTR       24284625 chr8:17104588-17104589(+) m6A 5'UTR       - chr8:17104608-17104609(+) m6A 5'UTR       - chr8:17104681-17104682(+) m6A 5'UTR       25456834 chr8:17104742-17104743(+) m6A 5'UTR       - chr8:17132324-17132325(+) m6A CDS       24981863 chr8:17142063-17142064(+) m6A 3'UTR//CDS       27773535 chr8:17142122-17142123(+) m6A 3'UTR//CDS       27773535 chr8:17157367-17157368(+) m6A exon//intron       25456834//22608085 chr8:17157384-17157385(+) m6A exon//intron       25456834//22608085 chr8:17157453-17157454(+) m6A exon//intron       25456834//24981863//22608085 chr8:17157480-17157481(+) m6A exon//intron       25456834//24981863//22608085 chr8:17157517-17157518(+) m6A exon//intron       25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	VPS37A	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10b
Interactor2: VPS37A

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	cRep//miRanda//PARalyzer//Targetscan
Support Database	RepTar//ViRBase//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BJAB cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.