Basic Information:

  VIRBase ID:  

VHID00427757

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6002

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:  MIMAT0002180          H2AZ2:  NM_012412     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10b	H2AZ2
miRBase Accession/Entrez ID	MIMAT0002180	94239
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	H2A.Z-2//H2AFV//H2AV

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	H2AZ2	chr7:44878112(-) A-I      intronic chr7:44879309(-) A-I      intronic chr7:44879758(-) A-I      intronic chr7:44879878(-) A-I      intronic chr7:44879885(-) A-I      intronic chr7:44880251(-) A-I      intronic chr7:44880270(-) A-I      intronic chr7:44880275(-) A-I      intronic chr7:44870526(-) A-I      intronic chr7:44886032(-) A-I      intronic chr7:44870541(-) A-I      intronic chr7:44877264(-) A-I      intronic chr7:44880288(-) A-I      intronic chr7:44880324(-) A-I      intronic chr7:44880330(-) A-I      intronic chr7:44881176(-) A-I      intronic chr7:44881233(-) A-I      intronic chr7:44881282(-) A-I      intronic chr7:44870574(-) A-I      intronic chr7:44870549(-) A-I      intronic chr7:44870690(-) A-I      intronic chr7:44870697(-) A-I      intronic chr7:44870703(-) A-I      intronic chr7:44870722(-) A-I      intronic chr7:44870732(-) A-I      intronic chr7:44870755(-) A-I      intronic chr7:44879086(-) A-I      intronic chr7:44884128(-) A-I      intronic chr7:44870758(-) A-I      intronic chr7:44870760(-) A-I      intronic chr7:44875765(-) A-I      intronic chr7:44879977(-) A-I      intronic chr7:44875829(-) A-I      intronic chr7:44875841(-) A-I      intronic chr7:44883384(-) A-I      intronic chr7:44883376(-) A-I      intronic chr7:44875843(-) A-I      intronic chr7:44876900(-) A-I      intronic chr7:44876960(-) A-I      intronic chr7:44884129(-) A-I      intronic chr7:44877151(-) A-I      intronic chr7:44877159(-) A-I      intronic chr7:44877295(-) A-I      intronic chr7:44870684(-) A-I      intronic chr7:44877655(-) A-I      intronic chr7:44877738(-) A-I      intronic chr7:44877747(-) A-I      intronic chr7:44877777(-) A-I      intronic chr7:44870520(-) A-I      intronic chr7:44870512(-) A-I      intronic chr7:44870431(-) A-I      intronic chr7:44870429(-) A-I      intronic chr7:44881340(-) A-I      intronic chr7:44870394(-) A-I      intronic chr7:44870385(-) A-I      intronic chr7:44882568(-) A-I      intronic chr7:44882655(-) A-I      intronic chr7:44870353(-) A-I      intronic chr7:44870352(-) A-I      intronic chr7:44877800(-) A-I      intronic chr7:44886170(-) A-I      intronic chr7:44882656(-) A-I      intronic chr7:44883295(-) A-I      intronic chr7:44883370(-) A-I      intronic chr7:44870405(-) A-I      intronic chr7:44868966(-) A-I      3'UTR chr7:44868983(-) A-I      3'UTR chr7:44868996(-) A-I      3'UTR chr7:44868997(-) A-I      3'UTR chr7:44869006(-) A-I      3'UTR chr7:44869008(-) A-I      3'UTR chr7:44868955(-) A-I      3'UTR chr7:44868995(-) A-I      3'UTR chr7:44882691(-) A-I      intronic chr7:44876245(-) A-I      intronic chr7:44876317(-) A-I      intronic chr7:44876155(-) A-I      intronic chr7:44876154(-) A-I      intronic chr7:44886067(-) A-I      intronic chr7:44881246(-) A-I      intronic chr7:44877627(-) A-I      intronic chr7:44879914(-) A-I      intronic chr7:44877662(-) A-I      intronic chr7:44876290(-) A-I      intronic chr7:44875722(-) A-I      intronic chr7:44876213(-) A-I      intronic chr7:44878058(-) A-I      intronic chr7:44870492(-) A-I      intronic chr7:44876255(-) A-I      intronic chr7:44874520(-) A-I      intronic chr7:44879928(-) A-I      intronic chr7:44884126(-) A-I      intronic chr7:44881249(-) A-I      intronic chr7:44876228(-) A-I      intronic chr7:44880258(-) A-I      intronic chr7:44876073(-) A-I      intronic chr7:44876273(-) A-I      intronic chr7:44879952(-) A-I      intronic chr7:44876370(-) A-I      intronic chr7:44880144(-) A-I      intronic chr7:44875826(-) A-I      intronic chr7:44870507(-) A-I      intronic chr7:44881144(-) A-I      intronic chr7:44876305(-) A-I      intronic chr7:44876424(-) A-I      intronic chr7:44876287(-) A-I      intronic chr7:44879883(-) A-I      intronic chr7:44880287(-) A-I      intronic chr7:44870752(-) A-I      intronic chr7:44877681(-) A-I      intronic chr7:44876471(-) A-I      intronic chr7:44876249(-) A-I      intronic chr7:44876265(-) A-I      intronic chr7:44876455(-) A-I      intronic chr7:44884077(-) A-I      intronic chr7:44876147(-) A-I      intronic chr7:44876337(-) A-I      intronic chr7:44876220(-) A-I      intronic chr7:44875835(-) A-I      intronic chr7:44870666(-) A-I      intronic chr7:44874546(-) A-I      3'UTR chr7:44869088(-) A-I      3'UTR chr7:44873223(-) A-I      3'UTR chr7:44868965(-) A-I      3'UTR chr7:44873214(-) A-I      3'UTR chr7:44873222(-) A-I      3'UTR chr7:44869034(-) A-I      3'UTR chr7:44874549(-) A-I      3'UTR chr7:44879959(-) A-I      intronic chr7:44882505(-) A-I      intronic chr7:44879958(-) A-I      intronic chr7:44879780(-) A-I      intronic chr7:44876339(-) A-I      intronic chr7:44870547(-) A-I      intronic chr7:44882483(-) A-I      intronic chr7:44886049(-) A-I      intronic chr7:44870654(-) A-I      intronic chr7:44874493(-) A-I      intronic chr7:44876177(-) A-I      intronic chr7:44878165(-) A-I      intronic chr7:44881174(-) A-I      intronic chr7:44880126(-) A-I      intronic chr7:44876757(-) A-I      intronic chr7:44878166(-) A-I      intronic chr7:44881319(-) A-I      intronic chr7:44877261(-) A-I      intronic chr7:44879742(-) A-I      intronic chr7:44882572(-) A-I      intronic chr7:44876026(-) A-I      intronic chr7:44875626(-) A-I      intronic chr7:44884171(-) A-I      intronic chr7:44877228(-) A-I      intronic chr7:44882590(-) A-I      intronic chr7:44870392(-) A-I      intronic chr7:44881359(-) A-I      intronic chr7:44883430(-) A-I      intronic chr7:44882626(-) A-I      intronic chr7:44878189(-) A-I      intronic chr7:44879031(-) A-I      intronic chr7:44870379(-) A-I      intronic chr7:44880364(-) A-I      intronic chr7:44870340(-) A-I      intronic chr7:44879709(-) A-I      intronic chr7:44878130(-) A-I      intronic chr7:44877698(-) A-I      intronic chr7:44877287(-) A-I      intronic chr7:44870393(-) A-I      intronic chr7:44878077(-) A-I      intronic chr7:44877250(-) A-I      intronic chr7:44870542(-) A-I      intronic chr7:44876406(-) A-I      intronic chr7:44875834(-) A-I      intronic chr7:44881357(-) A-I      intronic chr7:44879019(-) A-I      intronic chr7:44881177(-) A-I      intronic chr7:44870683(-) A-I      intronic chr7:44870417(-) A-I      intronic chr7:44886127(-) A-I      intronic chr7:44870644(-) A-I      intronic chr7:44877581(-) A-I      intronic chr7:44870380(-) A-I      intronic chr7:44877694(-) A-I      intronic chr7:44870759(-) A-I      intronic chr7:44876790(-) A-I      intronic chr7:44883356(-) A-I      intronic chr7:44877844(-) A-I      intronic chr7:44870709(-) A-I      intronic

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	H2AZ2	Chromatin K562 cells     - Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10b
Interactor2: H2AZ2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//Rep//Targetscan
Support Database	RepTar//VIRmiRNA//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//VIRmiRNA//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-1 cells//BC-3 cells//BCBL-1 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6A BC-1 derived 3'UTR clusters with seed matches to expressed miRNAs.