Detail Information

Basic Information:


  VIRBase ID:  

VHID00427632

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:           MSANTD4:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol kshv-miR-K12-10b MSANTD4
miRBase
Accession/Entrez ID		 MIMAT0002180 84437
Organism Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV) Homo sapiens
Category miRNA mRNA
Alias - KIAA1826

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MSANTD4
chr11:105877628(-) A-I      intronic
chr11:105876178(-) A-I      intronic
chr11:105876221(-) A-I      intronic
chr11:105877206(-) A-I      intronic
chr11:105876291(-) A-I      intronic
chr11:105877281(-) A-I      intronic
chr11:105877286(-) A-I      intronic
chr11:105877315(-) A-I      intronic
chr11:105877323(-) A-I      intronic
chr11:105877307(-) A-I      intronic
chr11:105877476(-) A-I      intronic
chr11:105877353(-) A-I      intronic
chr11:105877522(-) A-I      intronic
chr11:105877569(-) A-I      intronic
chr11:105877526(-) A-I      intronic
chr11:105877641(-) A-I      intronic
chr11:105877411(-) A-I      intronic
chr11:105877339(-) A-I      intronic
chr11:105877652(-) A-I      intronic
chr11:105877678(-) A-I      intronic
chr11:105876377(-) A-I      intronic
chr11:105877506(-) A-I      intronic
chr11:105877663(-) A-I      intronic
chr11:105877388(-) A-I      intronic
chr11:105877588(-) A-I      intronic
chr11:105877700(-) A-I      intronic
chr11:105876257(-) A-I      intronic
chr11:105877284(-) A-I      intronic
chr11:105876165(-) A-I      intronic
chr11:105877406(-) A-I      intronic
chr11:105877129(-) A-I      intronic
chr11:105877174(-) A-I      intronic
chr11:105877459(-) A-I      intronic
chr11:105877303(-) A-I      intronic
chr11:105877324(-) A-I      intronic
chr11:105877428(-) A-I      intronic
chr11:105877623(-) A-I      intronic
chr11:105876131(-) A-I      intronic
chr11:105876231(-) A-I      intronic
chr11:105886844(-) A-I      intronic
chr11:105877446(-) A-I      intronic
chr11:105877370(-) A-I      intronic
chr11:105877683(-) A-I      intronic
chr11:105876369(-) A-I      intronic
chr11:105877263(-) A-I      intronic
chr11:105877194(-) A-I      intronic
chr11:105877364(-) A-I      intronic
chr11:105886749(-) A-I      intronic
chr11:105877229(-) A-I      intronic
chr11:105877598(-) A-I      intronic
chr11:105877707(-) A-I      intronic
chr11:105877272(-) A-I      intronic
chr11:105877687(-) A-I      intronic
chr11:105876368(-) A-I      intronic
chr11:105877695(-) A-I      intronic
chr11:105877620(-) A-I      intronic
chr11:105877285(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MSANTD4
chr11:105866740-105866741(-) m6A exon       -
chr11:105866941-105866942(-) m6A exon       -
chr11:105866963-105866964(-) m6A exon       22608085
chr11:105867236-105867237(-) m6A exon       22608085
chr11:105867259-105867260(-) m6A exon       24981863//22608085
chr11:105867335-105867336(-) m6A exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:105880065-105880066(-) m6A 3'UTR//intron       27773535
chr11:105880079-105880080(-) m6A 3'UTR//intron       27773535
chr11:105880226-105880227(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:105880273-105880274(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:105880298-105880299(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr11:105880402-105880403(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:105880416-105880417(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:105880424-105880425(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr11:105880462-105880463(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:105880480-105880481(-) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr11:105880561-105880562(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:105880568-105880569(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:105880666-105880667(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:105880672-105880673(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr11:105880771-105880772(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr11:105881445-105881446(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr11:105881451-105881452(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr11:105881458-105881459(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22608085
chr11:105881589-105881590(-) m6A CDS       24284625//24981863//27773535//22608085
chr11:105881595-105881596(-) m6A CDS       24284625//24981863//27773535//22608085
chr11:105881661-105881662(-) m6A 5'UTR       24284625//24981863//27773535//22608085
chr11:105881743-105881744(-) m6A 5'UTR       24284625//24981863//27773535//22608085
chr11:105881755-105881756(-) m6A 5'UTR       24284625//24981863//27773535//22608085
chr11:105881782-105881783(-) m6A 5'UTR       24284625//24981863//27773535//22608085
chr11:105891718-105891719(-) m6A 5'UTR//intron       24981863//22608085
chr11:105891726-105891727(-) m6A 5'UTR//intron       24981863//22608085
chr11:105891769-105891770(-) m6A 5'UTR//intron       27773535
chr11:105892601-105892602(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//27773536//22608085
chr11:105892659-105892660(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr11:105892689-105892690(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr11:105892694-105892695(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085
chr11:105892769-105892770(-) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//27773536//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate MSANTD4
Chromatin K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleus HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: kshv-miR-K12-10b
Interactor2: MSANTD4

Evidence Support:


Weak-Evidence PAR-CLIP
Prediction-Evidence miRanda//PARalyzer//Rep//Targetscan
Support Database RepTar//ViRBase//VmiReg

References:


PMID 22100165 Target region 3'UTR
Source RepTar//ViRBase//VmiReg Interactor1 expression None
Tissue or cell line BC-3 cells Interactor2 expression None
Description Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.

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