Basic Information:

  VIRBase ID:  

VHID00427482

  Virus:  

Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)

  Host:  

Homo sapiens

  Confidence Score:  

0.6040

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      kshv-miR-K12-10b:  MIMAT0002180          SLC52A2:  NM_001363118     

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Interactor Information:

	Interactor1	Interactor2
Symbol	kshv-miR-K12-10b	SLC52A2
miRBase Accession/Entrez ID	MIMAT0002180	79581
Organism	Human gammaherpesvirus 8 (Kaposi's sarcoma herpesvirus, KSHV)	Homo sapiens
Category	miRNA	mRNA
Alias	-	BVVLS2//D15Ertd747e//GPCR41//GPR172A//hRFT3//PAR1//RFT3//RFVT2

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC52A2	chr8:145582223-145582224(+) m6A 5'UTR//intron       24981863 chr8:145582260-145582261(+) m6A 5'UTR//exon//intron       24981863 chr8:145582312-145582313(+) m6A 5'UTR//exon//intron       24209618//25456834//24981863//22575960 chr8:145582396-145582397(+) m6A 5'UTR//exon//intron       24209618//22575960 chr8:145582412-145582413(+) m6A 5'UTR//exon//intron       24209618//22575960 chr8:145582904-145582905(+) m6A 5'UTR//exon       24284625 chr8:145583327-145583328(+) m6A CDS//exon//intron       24284625 chr8:145583945-145583946(+) m6A 3'UTR//CDS//intron       24284625 chr8:145584649-145584650(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085 chr8:145584658-145584659(+) m6A CDS       24284625//25456834//24981863//26404942//22575960//22608085 chr8:145584691-145584692(+) m6A 3'UTR       24284625//25456834//24981863//26404942//22575960//22608085 chr8:145584783-145584784(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr8:145584856-145584857(+) m6A 3'UTR       24284625//25456834//24981863//22575960//22608085 chr8:145584893-145584894(+) m6A 3'UTR       25456834//24981863//22608085 chr8:145584918-145584919(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SLC52A2	Chromatin K562 cells     - Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: kshv-miR-K12-10b
Interactor2: SLC52A2

Evidence Support:

Weak-Evidence	PAR-CLIP
Prediction-Evidence	miRanda//PARalyzer//Rep//Targetscan
Support Database	RepTar//ViRBase//VmiReg

References:

PMID	22100165	Target region	3'UTR
Source	RepTar//ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	BC-3 cells	Interactor2 expression	None
Description	Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites.Clusters with seed matches to expressed miRNAs were considered candidate target sites. Of the clusters mapping to human 3'UTRs, 69% (BC-1) and 70% (BC-3) had seed matches to expressed miRNAs (Tables S6).Table S6B BC-3 derived 3'UTR clusters with seed matches to expressed miRNAs.